Category: 16629-19-9

Wan, Hai-Lan; Guan, Zhi; He, Yan-Hong published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Electrochemically Promoted Bifunctionalization of Alkynes for the Synthesis of β-Keto Sulfones》.Name: Thiophene-2-sulfonyl chloride The article contains the following contents:

An electrochem. oxidative difunctionalization of internal and terminal alkynes with sulfonyl hydrazides for the synthesis of β-keto sulfones has been achieved. The reaction involves the addition of sulfonyl radicals to alkynes, and the resulting alkenyl radicals are oxidized to alkenyl cations, which are then nucleophilically attacked by H2O, followed by tautomerization to form β-keto sulfones. The method is green and sustainable as it is catalyst-free, oxidant-free, and additive-free. The new C-O and C-S bonds can be constructed in one-pot to directly access β-keto sulfone derivatives In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Name: Thiophene-2-sulfonyl chloride) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Name: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Visible-Light-Driven Remote C-H Chlorination of Aliphatic Sulfonamides with Sodium Hypochlorite》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Zhu, Yanshuo; Wang, Juan-Juan; Wu, Danhua; Yu, Wei. Reference of Thiophene-2-sulfonyl chloride The article mentions the following:

The C(sp3)-H chlorination of aliphatic sulfonamides was realized by visible-light photoredox catalysis with Ru(bpy)3Cl2 as photocatalsyt and NaOCl·5H2O crystals as the chlorinating agent. The reaction proceeded in a tandem pattern of N-H chlorination and Hofmann-Loffler-Freytag chlorination. A variety of differently substituted sulfonamides were chlorinated in this way in high yield. A radical-chain mechanism was proposed for the reaction on the basis of exptl. evidence. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Reference of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Reference of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jiang, Yi-Qian; Gu, Zheng-Yang; Chen, Ye; Xia, Ji-Bao published an article in 2021. The article was titled 《Pd-Catalyzed Amidation of Silyl Enol Ethers With CO and Azides via an Isocyanate Intermediate》, and you may find the article in Asian Journal of Organic Chemistry.SDS of cas: 16629-19-9 The information in the text is summarized as follows:

An efficient Pd-catalyzed amidation of silyl enol ethers to produce β-ketoamides I [R = Me, Ph, 4-MeC6H4, etc.; R1 = n-Bu, Ph, Bn, etc.; R2 = H, Me, Et; RR2 = (CH2)3] had been developed using carbon monoxide and sulfonyl azides. The tandem reaction provided a simple and straightforward approach for the synthesis of β-ketoamides I under mild conditions without any additive. The mechanistic studies indicated that the reaction undergoes via an in situ generated isocyanate intermediate. In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, microwave-assisted synthesis, biological evaluation and molecular modeling studies of 4-phenylthiazoles as potent fatty acid amide hydrolase inhibitors》 was written by Wilt, Stephanie R.; Rodriguez, Mark; Le, Thanh N. H.; Baltodano, Emily V.; Salas, Adrian; Pecic, Stevan. Application of 16629-19-9 And the article was included in Chemical Biology & Drug Design in 2020. The article conveys some information:

Endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are endogenous lipids that activate cannabinoid receptors. Activation of these receptors produces anti-inflammatory and analgesic effects. Fatty acid amide hydrolase (FAAH) is a membrane enzyme that hydrolases endocannabinoids; thus, inhibition of FAAH represents an attractive approach to develop new therapeutics for treating inflammation and pain. Previously, potent rat FAAH inhibitors containing 2-naphthyl- and 4-phenylthiazole scaffolds were identified, but up to the present time, very little structure-activity relationship studies have been performed on these moieties. We designed and synthesized several analogs containing these structural motifs and evaluated their inhibition potencies against human FAAH enzyme. In addition, we built and validated a homol. model of human FAAH enzyme and performed docking experiments We identified several inhibitors in the low nanomolar range and calculated their ADME predicted values. These FAAH inhibitors represent promising drug candidates for future preclin. in vivo studies. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Metal-Free Electrochemical Coupling of Vinyl Azides: Synthesis of Phenanthridines and β-Ketosulfones》 was written by Li, Guodong; Kong, Xianqiang; Liang, Qi; Lin, Long; Yu, Ke; Xu, Bo; Chen, Qianjin. Recommanded Product: Thiophene-2-sulfonyl chloride And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

The authors reported an efficient and environmentally benign electrochem. synthesis of phenanthridines by oxidative coupling of vinyl azides with sodium azide or benzenesulfonyl hydrazides, for the first time. The reaction conditions are mild, and no addnl. metal-catalyst or exogenous oxidants are needed. The protocol has broad substrate scope and high functional group tolerance. Furthermore, this green electrochem. procedure can be readily extended to the synthesis of β-ketosulfones. Gram scale reactions further demonstrate the practicability. In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of Thiophene-2-sulfonyl chlorideIn 2020 ,《Electrochemical Oxidation-induced Difunctionalization of Alkynes and Alkenes with Sulfonyl Hydrazides: Facile Access to β-Selenovinyl Sulfones and β-Ketosulfones》 was published in Asian Journal of Organic Chemistry. The article was written by Kong, Xianqiang; Yu, Ke; Chen, Qianjin; Xu, Bo. The article contains the following contents:

Herein, an efficient electrochem. oxidative selenosulfonylation of alkynes R1CCR2 (R1 = Et, Ph, naphthalen-2-yl, etc.; R2 = H, Me, Ph, etc.) and oxysulfonylation of alkenes R3CH=CH2 (R3 = H, 4-nitrophenyl, 3,4-dichlorophenyl, etc.) without use of metal catalysts were reported. This method provides a practical access to a wide range of β-(seleno)vinyl sulfones RS(O)2C(R2)=C(R1)SePh (R = Et, 4-chlorophenyl, thiophen-2-yl, etc.) and β-keto sulfones RS(O)2CH2C(O)R3. These reactions can tolerate various functional groups and be easily scaled-up. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Safety of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Safety of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex》 was published in Cell (Cambridge, MA, United States) in 2020. These research results belong to Xing, Changrui; Zhuang, Youwen; Xu, Ting-Hai; Feng, Zhiwei; Zhou, X. Edward; Chen, Maozi; Wang, Lei; Meng, Xing; Xue, Ying; Wang, Junmei; Liu, Heng; McGuire, Terence Francis; Zhao, Gongpu; Melcher, Karsten; Zhang, Cheng; Xu, H. Eric; Xie, Xiang-Qun. Recommanded Product: Thiophene-2-sulfonyl chloride The article mentions the following:

Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders, inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The mechanisms underlying CB2 activation and signaling are poorly understood but critical for drug design. Here we report the cryo-EM structure of the human CB2-Gi signaling complex bound to the agonist WIN 55,212-2. The 3D structure reveals the binding mode of WIN 55,212-2 and structural determinants for distinguishing CB2 agonists from antagonists, which are supported by a pair of rationally designed agonist and antagonist. Further structural analyses with computational docking results uncover the differences between CB2 and CB1 in receptor activation, ligand recognition, and Gi coupling. These findings are expected to facilitate rational structure-based discovery of drugs targeting the cannabinoid system. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

COA of Formula: C4H3ClO2S2In 2022 ,《Carbene-Catalyzed Enantioselective Sulfonylation of Enone Aryl Aldehydes: A New Mode of Breslow Intermediate Oxidation》 was published in Journal of the American Chemical Society. The article was written by Deng, Rui; Wu, Shuquan; Mou, Chengli; Liu, Jianjian; Zheng, Pengcheng; Zhang, Xinglong; Chi, Yonggui Robin. The article contains the following contents:

A carbene-catalyzed sulfonylation reaction between enone aryl aldehydes and sulfonyl chlorides is disclosed. The reaction effectively installs sulfone moieties in a highly enantioselective manner to afford sulfone-containing bicyclic lactones. The sulfonyl chloride behaves both as an oxidant and a nucleophilic substrate (via its reduced form) in this N-heterocyclic carbene (NHC)-catalyzed process. The NHC catalyst provides both activation and stereoselectivity control on a very remote site of enone aryl aldehyde substrates. Water plays an important role in modulating catalyst deactivation and reactivation routes that involve reactions between NHC and sulfonyl chloride. Exptl. studies and DFT calculations suggest that an unprecedented intermediate and a new oxidation mode of the NHC-derived Breslow intermediate are involved in the new asym. sulfonylation reaction. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9COA of Formula: C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. COA of Formula: C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Chen, Yasu; Wu, Xinxin; Yang, Shan; Zhu, Chen published an article in Angewandte Chemie, International Edition. The title of the article was 《Asymmetric Radical Cyclization of Alkenes by Stereospecific Homolytic Substitution of Sulfinamides》.Electric Literature of C4H3ClO2S2 The author mentioned the following in the article:

Authors report a novel asym. radical cyclization of alkenes via stereospecific homolytic substitution of sulfinamides. This reaction produces a variety of cyclic sulfinamides with excellent stereocontrol. The protocol features broad functional group tolerance, high product diversity, and easy accessibility to feedstocks, and outlines a new pathway for the synthesis of chiral cyclic sulfinamides. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Electric Literature of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Electric Literature of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of Thiophene-2-sulfonyl chlorideIn 2022 ,《Analogue Based Design, Synthesis, Biological Evaluation, and Molecular Docking of Some Thalidomide Metabolites as Selective Cytotoxic and Antiangiogenic Agents against Multiple Myeloma》 was published in Russian Journal of Bioorganic Chemistry. The article was written by Abhijit Saha; Sarker, Koushik; Ghosh, Avijit; Mishra, Suvasish; Sen, Subrata. The article contains the following contents:

The synthesis and evaluation of some bioisosteres of thalidomide metabolites for antiangiogenic and anticancer activity on multiple myeloma are described in this article. Four compounds, di-Et 2-(thiophene-2-sulfonamido) pentanedioate, N1,N5-diethyl-2-(thiophene-2-sulfonamido) pentanediamide, N1,N5-dihexyl-2-(thiophene-2-sulfonamido) pentanediamide, and N-(1,5-dioxo-1,5-bis(2-phenylhydrazinyl)pentan-2-yl)thiophene-2-sulfonamide exhibit cytotoxic effect on human multiple myeloma cell line (RPMI8226) with IC50 (in μM) values 3.33, 0.75, 1.23, and 3.28, resp. The in vitro studies on human umbilical vein endothelial cells (HUVEC) and normal African green monkey kidney epithelial cells (Vero cell line) concluded that these compounds bear antiangiogenic properties and are selectively cytotoxic to cancer cells. Except for N-(1,5-dioxo-1,5-bis(2-phenylhydrazinyl)pentan-2-yl)Thiophene-2-sulfonamide, it was found to be toxic to normal epithelial cells. The trypan blue dye exclusion method was used to conduct an antiproliferative assay of the active compounds on HUVECs. The phosphorylation inhibition assay on Vascular Endothelial Growth Factor Receptor-2 Tyr-1175 (VEGFR-2 Tyr-1175) revealed that N1,N5-diethyl-2-(thiophene-2-sulfonamido) pentanediamide and N1,N5-dihexyl-2-(thiophene-2-sulfonamido) pentanediamide are active, indicating that the mols. have antiangiogenic activity by targeting VEGFR-2 Tyr-1175, a key autophosphorylation site that regulates pro-angiogenic responses. On CDOCKER, a mol. docking study of the most active compound N1,N5-diethyl-2-(thiophene-2-sulfonamido) pentanediamide with VEGFR-2 revealed that they might interact with the essential amino acid residues, with a binding energy of -105.304 kcal/mol. In the part of experimental materials, we found many familiar compounds, such as Thiophene-2-sulfonyl chloride(cas: 16629-19-9Quality Control of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Quality Control of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics