Category: 16629-19-9

《Regioselective Chloro-thiolation of Alkenes with Sulfonyl Chlorides》 was published in Journal of Organic Chemistry in 2020. These research results belong to Wei, Jingjing; Liang, Shuaishuai; Jiang, Lvqi; Mumtaz, Yasir; Yi, Wen-bin. Recommanded Product: Thiophene-2-sulfonyl chloride The article mentions the following:

A newly developed sulfonyl chlorides-based regioselective chloro-thiolation of alkenes has been disclosed, the reaction is compatible with a variety of functional groups and can be scaled up to the gram-scale with no loss in yield. The employment of readily available reactants, mild reaction conditions, and high regioselectivity makes this process very practical. Mechanistic studies revealed a possible free radical reaction pathway. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Cu-Catalyzed Direct C7 Sulfonylation of Indolines with Arylsulfonyl Chlorides》 was published in Journal of Organic Chemistry in 2020. These research results belong to Zhi, Changlei; Wang, Qiuling; Liu, Shuang; Xue, Yuting; Shi, Linlin; Zhu, Xinju; Hao, Xin-Qi; Song, Mao-Ping. Product Details of 16629-19-9 The article mentions the following:

An efficient Cu-catalyzed direct sulfonylation of indolines with easily accessible sulfonyl chlorides has been realized under an air atm. via a chelation-assisted strategy. This protocol exhibits several unique characteristics, including broad substrate scope, good functional group tolerance, and operational convenience, which enable a regioselective access to a variety of C-7 functionalized indoline scaffolds in moderate to good yields. The mechanistic study reveals that the sulfonyl radical might be involved in this transformation. The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Product Details of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Product Details of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Lixia; Wang, Chengming published their research in Reaction Chemistry & Engineering in 2021. The article was titled 《Copper-catalyzed redox-neutral regioselective chlorosulfonylation of vinylarenes》.Application of 16629-19-9 The article contains the following contents:

A copper-catalyzed redox-neutral, regioselective aromatic alkene chlorosulfonylation reaction has been developed. This protocol features simple procedure, easily accessible materials and good functional group tolerance. Moreover, it could be amplified to a gram scale and smoothly applied to the late-stage modification of bioactive mol. derivatives In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Hydrolysis of dihydroisoquinoline derivatives activated by sulfonyl or acyl chloride》 was published in Canadian Journal of Chemistry in 2020. These research results belong to Liu, Jianchen; Dang, Xinxin; Chen, Dan; Zhang, Xinyuan; Yang, Zhonglie; Lin, Li; Jiang, Hezhong; Li, Jiahong. Recommanded Product: 16629-19-9 The article mentions the following:

A new, efficient and mild strategy for hydrolysis of 3,4-dihydroisoquinoline imines activated by sulfonyl chloride or acyl chloride was developed, by which method ketosulfonamides I [R = CF3, Ph, 4-MeC6H4, etc.; R1 = H, 5-F, 4-MeO, 5-MeO, 6-MeO, 4,5-di-MeO; R2 = Ph, 4-Br, 2-NO2, etc.] and ketoamides II [R3 = Me, Ph, 2-furyl, etc.] were synthesized. This process tolerated broad scope with respect to both the sulfonyl chloride and acyl chloride with moderate to excellent yields. This protocol features a broad substrate scope for various kinds of 3,4-dihydroisoquinoline and mild reaction conditions without using strong acidic or basic conditions. These features showed that this user-friendly and simple system could be applied in the future to the synthesis of a broader range of amino benzophenones. The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, synthesis and anticancer evaluation of 1,2,4-thiadiazole linked benzoxazole-quinazoline derivatives》 was published in Chemical Data Collections in 2020. These research results belong to Perupogu, Neerada; Krishna, Ch. Murali; Ramachandran, Dittakavi. Application of 16629-19-9 The article mentions the following:

The authors designed and synthesized a series of 1,2,4-thiadiazole-incorporated benzoxazole-quinazoline derivatives I [Ar = 2-thiophenyl, 4-MeC6H4, 3,5-Cl2C6H3, etc.] and screened them for anticancer activity against human cancer cell lines that included MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) and A2780 (ovarian cancer). The clin. agent etoposide was chosen as the pos. control. Among the tested compounds, I [Ar = 5-methylisoxazol-4-yl] showed efficient anticancer activities against the four cancer cell lines. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis of N-phenylsulfonamide derivatives and investigation of some esterase enzymes inhibiting properties》 was published in Bioorganic Chemistry in 2020. These research results belong to Akin Kazancioglu, Elif; Senturk, Murat. Recommanded Product: 16629-19-9 The article mentions the following:

In this study, synthesis of nine N-phenylsulfonamide derivatives I [R = Me, 4-methoxyphenyl, 4-fluorophenyl, 2-thiophenyl, etc.] was designed by starting from aniline, which was the simplest aromatic amine. These compounds I were obtained in yields between 69 and 95%. Inhibitory properties of synthesized compounds I on carbonic anhydrase I (CA I), CA II isoenzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were investigated. The compound I [R = 2-naphthyl] for CA I, AChE and BChE, 2 for CA II showed a very active inhibition profile (KI 45.7 ± 0.46 for CA I, 33.5 ± 0.38 nM for CA II, 31.5 ± 0.33 nM for AChE and 24.4 ± 0.29 nM for BChE). The results indicate that these N-phenyl-sulfonamide derivatives I were potent CA and cholinesterases and new potential drugs. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 16629-19-9In 2021 ,《tert-Butyl Hydroperoxide-Initiated Radical Cyclization of 1-(Allyloxy)-2-(1-Arylvinyl)Benzenes with Sulfinic Acids to Access Sulfonated Benzoxepines》 was published in Advanced Synthesis & Catalysis. The article was written by Zhou, Nengneng; Kuang, Kaimo; Wu, Meixia; Wu, Sixin; Xu, Qiankun; Xia, Ziqin; Zhang, Man. The article contains the following contents:

A tert-Bu hydroperoxide-initiated radical cyclization of 1-(allyloxy)-2-(1-arylvinyl)benzenes I (R = H, F, Cl, Br, t-Bu; R1 = H; R2 = C6H5, 4-BrC6H4, 2-thienyl, etc.; R3 = H, Me; R4 = H, Me, OMe, Br; R5 = H, t-Bu; RR1 = -CH=CHCH=CH-; X = O, NTs) with sulfinic acids R6S(O)OH (R6 = 4-CH3C6H4, 1-naphthyl, 2-thienyl, etc.) for the construction of sulfonated benzoxepines II (R7 = C6H5, 4-BrC6H4, 2-thienyl, etc.; R8 = H, Me) is developed. This reaction involves a radical pathway and offers a straightforward route to the formation of seven-membered ring via sulfonylation/cyclization process. This methodol. features mild reaction conditions, a broad substrate scope and good functional group tolerance. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Kump, Karson J.; Miao, Lei; Mady, Ahmed S. A.; Ansari, Nurul H.; Shrestha, Uttar K.; Yang, Yuting; Pal, Mohan; Liao, Chenzhong; Perdih, Andrej; Abulwerdi, Fardokht A.; Chinnaswamy, Krishnapriya; Meagher, Jennifer L.; Carlson, Jacob M.; Khanna, May; Stuckey, Jeanne A.; Nikolovska-Coleska, Zaneta. Computed Properties of C4H3ClO2S2 The article mentions the following:

Anti-apoptotic Bcl-2 family proteins are overexpressed in a wide spectrum of cancers and have become well validated therapeutic targets. Cancer cells display survival dependence on individual or subsets of anti-apoptotic proteins that could be effectively targeted by multimodal inhibitors. We designed a 2,5-substituted benzoic acid scaffold that displayed equipotent binding to Mcl-1 and Bfl-1. Structure-based design was guided by several solved cocrystal structures with Mcl-1, leading to the development of compound 24, which binds both Mcl-1 and Bfl-1 with Ki values of 100 nM and shows appreciable selectivity over Bcl-2/Bcl-xL. The selective binding profile of 24 was translated to on-target cellular activity in model lymphoma cell lines. These studies lay a foundation for developing more advanced dual Mcl-1/Bfl-1 inhibitors that have potential to provide greater single agent efficacy and broader coverage to combat resistance in several types of cancer than selective Mcl-1 inhibitors alone. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Computed Properties of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Computed Properties of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Visible-light-promoted N-centered radical generation for remote heteroaryl migration》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Liu, Chengkou; Cai, Chen; Yuan, Chengcheng; Jiang, Qiang; Fang, Zheng; Guo, Kai. SDS of cas: 16629-19-9 The article mentions the following:

An efficient visible-light-mediated N-H heteroarylation via remote heteroaryl ipso-migration was accomplished. Moderate to good yields were obtained with good functional group tolerance. Moreover, a simple and readily available organic photoredox catalyst was employed, avoiding the use of complex and costly noble metal compounds In the part of experimental materials, we found many familiar compounds, such as Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Chang, Xiaoqiang; Chen, Xingyu; Lu, Sixian; Zhao, Yifan; Ma, Yue; Zhang, Dong; Yang, Lan; Sun, Peng published an article in Advanced Synthesis & Catalysis. The title of the article was 《Electrochemical [3+2] Cycloaddition of Anilines and 1,3-Dicarbonyl Compounds: Construction of Multisubstituted Indoles》.Category: chlorides-buliding-blocks The author mentioned the following in the article:

Herein, the intermol. electro-oxidative cycloaddition of anilines and com. available 1,3-dicarbonyl compds was reported. This method provided an alternative route for the synthesis of a broad range of multisubstituted indoles I [R1 = H, 5-EtO, 6-Cl,5-MeO, etc.; R2 = Ts, benzenesulfonyl, ethylsulfonyl, etc.; R3 = Ph, 4-MeC6H4, 4-MeOC6H4, etc.] without a transition-metal catalyst or external chem. oxidant. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Category: chlorides-buliding-blocks) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics