Category: 16629-19-9

In 2022,Tantawy, Ahmed H.; Farag, Shaimaa M.; Abdel-Haleem, Doaa R.; Mohamed, Hany I. published an article in Bioorganic Chemistry. The title of the article was 《Facile synthesis, larvicidal activity, biological effects, and molecular docking of sulfonamide-incorporating quaternary ammonium iodides as acetylcholinesterase inhibitors against Culex pipiens L》.Electric Literature of C4H3ClO2S2 The author mentioned the following in the article:

Insecticides participate with a vital role in our lives especially in preventing the spread of human diseases via controlling the dangerous pests. It is a challenge to identify alternatives to the ordinary insecticides with new mode of action to be used for mosquitoes′ control in an environmentally sustainable manner. Using a facile two-step procedure, three novel series of sulfonamide-incorporating quaternary ammonium iodides (3a-i, 4a-i and 5a-i) were synthesized and their chem. structures were successfully characterized. The uncharged sulfonamide intermediates (2a-i) were constructed through simple amidation of the corresponding (hetero)aryl sulfonyl chlorides then the cationic target mols. were formed by quaternizing the tertiary nitrogen with Me, Et, and allyl iodides. The larvicidal activities and biol. effects of most synthesized compounds against Culex pipiens L. were extensively investigated and they exhibited good and comparable activities to temephos. Among these hybrids, 4a showed the most potent activity with LC50 = 26.71 ppm. Addnl., the developmental durations of larval and pupal stages were significantly prolonged after treatment with all concentrations of 4h. At high concentration (160 ppm) of 4a and 4b, no adults emerged due to the complete death of pupae, and consequently zero growth index. Moreover, the results of the mol. docking demonstrated that the activities of compounds correlate partially to their binding with acetylcholinesterase (AChE) and it is not the sole parameter for determining the activity. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Electric Literature of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Electric Literature of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C4H3ClO2S2In 2021 ,《Visible-Light-Driven Sulfonylation/Cyclization to Access Sulfonylated Benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones》 was published in Chemistry – An Asian Journal. The article was written by Wang, Chen; Sun, Guoquan; Huang, Hong-Li; Liu, Jing; Tang, Hua; Li, Yinghua; Hu, Honggang; He, Shipeng; Gao, Fei. The article contains the following contents:

Visible-light-driven sulfonylation/cyclization of N-methacryloyl-2-phenylbenzoimidazoles has been successfully developed. Using com. available sulfonyl chloride as sulfonylation reagent, a wide range of sulfonylated benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones with potential antitumor activity were provided in acceptable to excellent yields. This method has the advantages of mild reaction conditions and outstanding functional group tolerance, and provides a new strategy for the development of potential antitumor lead compounds In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Formula: C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Formula: C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C4H3ClO2S2In 2022 ,《Photo-Triggered Self-Induced Homolytic Dechlorinative Sulfonylation/Cyclization of Unactivated Alkenes: Synthesis of Quinazolinones Containing a Sulfonyl Group》 appeared in Advanced Synthesis & Catalysis. The author of the article were Sun, Bin; Ding, Hao; Tian, Hai-Xia; Huang, Pan-Yi; Jin, Can; Wu, Chun-Lei; Shen, Run-Pu. The article conveys some information:

A self-photocatalyzed sulfonylation/cyclization of quinazolinones containing unactivated alkenes with various sulfonyl chlorides was developed. The protocol provided access to sulfonyl radicals via energy transfer from quinazolinone skeleton to sulfonyl chloride. Notably, transformations proceeded without any external photocatalysts, additives, or oxidants, providing an alternative method for fabricating sulfonylated compounds I [R = Et, cyclopropyl, Ph, etc.; R1 = H, 3-F, 2-MeO, etc.; n = 0, 1].Thiophene-2-sulfonyl chloride(cas: 16629-19-9Computed Properties of C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Computed Properties of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Gao, Yuting; Sun, Yang; Fang, Xianfu; Zhao, Guixian; Li, Xufeng; Zhang, Gong; Li, Yangfeng; Li, Yizhou published an article in Organic Chemistry Frontiers. The title of the article was 《Development of on-DNA vinyl sulfone synthesis for DNA-encoded chemical libraries》.Synthetic Route of C4H3ClO2S2 The author mentioned the following in the article:

The DNA-encoded chem. library (DEL) technol. is a novel drug discovery tool, benefiting from its large number of compound collections with chem. space coverage. Vinyl sulfone is a privileged functional group, eliciting diverse pharmacol. activities as the covalent warhead. In this report, we incorporated vinyl sulfone into the DEL chem. field by developing a mild and efficient DNA-compatible method starting from simple sodium sulfinates and DNA-conjugated alkenes, affording a broad substrate scope with moderate-to-excellent conversions. Further chem. transformations including the thiol-Michael addition reaction, together with enzymic ligation, were also successfully implemented to demonstrate the feasibility of this DNA-compatible synthesis in DEL construction. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Synthetic Route of C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Synthetic Route of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 16629-19-9In 2021 ,《Synthesis, biological evaluation and molecular docking study of some new rohitukine analogs as protein tyrosine phosphatase 1B inhibitors》 was published in Bioorganic Chemistry. The article was written by Balaramnavar, V. M.; Srivastava, R.; Varshney, S.; Kumar, S.; Rawat, A. K.; Chandasana, H.; Chhonker, Y. S.; Bhatta, R. S.; Srivastava, A. K.; Gaikwad, A. N.; Lakshmi, V.; Saxena, A. K.. The article contains the following contents:

Rohitukine (RH) I [R = H] was derivatized to different aryl sulfonated derivatives I [R = 4-MeC6H4SO2, 2-O2NC6H4SO2, 2-thienylsulfonyl, etc.] by treating with the corresponding aryl sulfonyl chlorides. These derivatives were tested in-vitro on protein tyrosine phosphatase 1B (PTP1B) inhibition. Among these the active compounds I [R = 4-O2NC6H4SO2, 3-O2NC6H4SO2, 2,4,6-tri-MeC6H2SO2, 1-naphthylsulfonyl] significantly inhibited the PTP1B by 51.3%, 65.6%, 71.9%, and 55.9% resp. at 10μg/mL, the results were also supported by in-silico docking experiments The most potent compound I [R = 2,4,6-tri-MeC6H2SO2] was analyzed for antidiabetic and antidyslipidemic activity in vivo. It showed a marked reduction in blood glucose level (random and fasting) and serum insulin level in db/db mice. It improved glucose intolerance as ascertained by the oral glucose tolerance test (OGTT). These NCEs (New Chem. Entities) also lowered cholesterol and triglyceride profiles while improved high-d. lipoprotein cholesterol in db/db mice. The compound I [R = 2,4,6-tri-MeC6H2SO2] was further evaluated for antiadipogenic activity on MDI (Methylisobutylxanthine, dexamethasone, and insulin)-induced adipogenesis, where it significantly inhibited MDI-induced adipogenesis in 3 T3-L1 preadipocytes, at 10μM and 20μM concentration These results were compared with the parent compound I [R = H] which inhibited 35% and 45% lipid accumulation while the RH analog compound I [R = 2,4,6-tri-MeC6H2SO2] inhibited the lipid accumulation by 41% and 51% at 10 and 20μM concentration, resp. These results well corroborated with in-silico studies. The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Yu, Xiao; Zhu, Wenjing; Liu, Hongyan; Liu, Yi; Li, Hongshuang; Han, Junfen; Duan, Guiyun; Bai, Zhushuang; Zhang, Pengfei; Xia, Chengcai published an article in Organic & Biomolecular Chemistry. The title of the article was 《Practical chemoselective aromatic substitution: the synthesis of N-(4-halo-2-nitrophenyl)benzenesulfonamide through the efficient nitration and halogenation of N-phenylbenzenesulfonamide》.SDS of cas: 16629-19-9 The author mentioned the following in the article:

A novel route involving the metal-promoted tandem nitration and halogenation of N-phenylbenzenesulfonamide to synthesize N-(4-halo-2-nitrophenyl)benzenesulfonamide derivatives has been developed. The method shows highly practical chemoselective and functional group compatibility. In addition, it employs insensitive and inexpensive Cu(NO3)2·3H2O, Fe(NO3)3·9H2O, and NH4NO3 as the nitration reagents, and it provides a direct approach for the preparation of 4-halo-2-nitroaniline, which is a crucial intermediate for the synthesis of benzimidazoles and quinoxaline derivatives In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Jiajun; Li, Guodong; Yu, Ke; Xu, Bo; Chen, Qianjin published an article in 2022. The article was titled 《Electrochemical Sulfonylation-Induced Lactonization of Alkenes: Synthesis of Sulfonyl Phthalides》, and you may find the article in Journal of Organic Chemistry.HPLC of Formula: 16629-19-9 The information in the text is summarized as follows:

An electrochem. cascade sulfonylation and lactonization process of alkenes and a most widely used arylsulfonylation reagent-sulfonyl hydrazines-was developed for the first time. This electrochem. sulfonyl lactonization avoids the use of toxic metal catalysts or stoichiometric oxidants and was carried out under mild conditions. The target product γ-sulfonylated phthalides with broad and excellent substrate tolerance were achieved. The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9HPLC of Formula: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. HPLC of Formula: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Yan; Lin, Zhipeng; Ackermann, Lutz published their research in Chemistry – A European Journal in 2021. The article was titled 《Electrochemical C-H Amidation of Heteroarenes with N-Alkyl Sulfonamides in Aqueous Medium》.Name: Thiophene-2-sulfonyl chloride The article contains the following contents:

The construction of C-N bonds by free radical reactions represents a powerful synthetic approach for direct C-H amidations of arenes or heteroarenes. Developing efficient and more environmentally friendly synthetic methods for C-H amidation reactions remains highly desirable. Herein, metal-free electrochem. oxidative dehydrogenative C-H amidations of heteroarenes with N-alkylsulfonamides have been accomplished. The catalyst- and chem.-oxidant-free C-H amidation features an ample scope and employs electricity as the green and sole oxidant. A variety of heteroarenes, including indoles, pyrroles, benzofuran and benzothiophene, thereby underwent this C(sp2)-H nitrogenation. Cyclic voltammetry studies and control experiments provided evidence for nitrogen-centered radicals being directly generated under metal-free electrocatalysis. In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9Name: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Name: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhu, Baoxiang; Wang, Zhao; Xi, Hui; Feng, Zengqiang; Wang, Binglei; Jiao, Wenyang; Li, Zhongxian; Wang, Zechao; Wu, Junliang published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Visible-light-promoted divergent functionalizations of methylenecyclopropanes》.COA of Formula: C4H3ClO2S2 The article contains the following contents:

Simple and convenient visible-light-promoted radical monofunctionalization and difunctionalization of methylenecyclopropanes via ring-opening and cyclization processes was developed for the syntheses of difluoromethyl compounds, alkyl compounds, halides, and sulfonyl compounds e.g., I in moderate to excellent yields. The methodologies feature a wide substrate scope and tolerate various functional groups. A possible radical mechanism was investigated and proven as a single electron transfer (SET) procedure.Thiophene-2-sulfonyl chloride(cas: 16629-19-9COA of Formula: C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. COA of Formula: C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhou, Nengneng; Kuang, Kaimo; Wu, Meixia; Wu, Sixin; Xia, Ziqin; Xu, Qiankun; Zhang, Man published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Visible-light-induced radical cascade cyclization of 1-(allyloxy)-2-(1-arylvinyl)benzenes with sulfonyl chlorides for the synthesis of sulfonated benzoxepines》.SDS of cas: 16629-19-9 The article contains the following contents:

A visible light photocatalyzed cascade sulfonylation/cyclization of 1-(allyloxy)-2-(1-arylvinyl)benzenes I (X = O; R1 = H, 4-F, 5-Me, 3,4-benzo, etc.; R2 = Ph, 2-MeC6H4, 4-BrC6H4, etc.; R3 = H, Me) and their analogs I (X = CH2, NTs; R1 = R3 = H; R2 = Ph) with sulfonyl chlorides R4SO2Cl (R4 = Me, cyclopropyl, 4-MeC6H4, 1-naphthyl, 2-thienyl, etc.) for the construction of sulfonated benzoxepines and analogs II has been developed. In the presence of Eosin Y (2.0 mol%) as a photocatalyst and Na2CO3 as a base, the reactions proceed smoothly to afford seven-membered rings in good yields. This transformation features wide substrate scope, the use of easily accessible materials and excellent functional group tolerance. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics