Category: 1592-20-7

Cyganowski, Piotr published the artcile< Fully recyclable gold-based nanocomposite catalysts with enhanced reusability for catalytic hydrogenation of p-nitrophenol>, Category: chlorides-buliding-blocks, the main research area is nitrophenol hydrogenation recyclable gold nanocomposite catalyst reusability.

Nanocomposite (NC) materials, which demonstrate catalytic activity under mild conditions, have garnered considerable attention due to the environmental hazards associated with aromatic nitro compounds Herein, a novel in-situ synthesis of NCs with zero-valent Au (Au°) is proposed. These materials are based on suspension copolymers with mol. reactors that enable the fabrication of Au° and the enhancement of both the catalytic activity and reusability. NCs were obtained using amino-based nanoreactors (3-14 mmol per g of a polymer) derived from polyethyleneimine (PEI), 1-(2-hydroxyethyl)piperazine (HEP), 1,4-bis(3-aminopropyl)piperazine (APP). The resultant Au@PEI, Au@HEP, and Au@APP NCs were investigated using optical microscopy, SEM, and TEM. Addnl., the physiochem. structures of both the polymeric matrix and Au° were evaluated using, i.a., FT-IR and XRD. The so-obtained NCs were used as nanocatalysts (NCats) for the catalytic hydrogenation of 4-nitrophenol (4-NP) under mild conditions. The method developed for the synthesis of NCs produced gold-based NCats with 25-37% Au° content. The synergism between the polymeric matrix and Au° enabled the hydrogenation of 4-NP within approx. 30-38 min with a rate constants of 0.071 min-1 (Au@HEP) and 0.028 min-1 (Au@APP) and, resp. The spherical millimetric morphol. of the polymeric support facilitated the facile recyclability of NCats that maintained their catalytic activity for more than 10 cycles of 4-NP reduction

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about Hydrogenation. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Wen-Li; Jin, Ren-Hua published the artcile< A unique polymersome covered by loop-cluster polyamine corona>, Product Details of C9H9Cl, the main research area is methyloxazoline phenyloxazoline amphiphilic diblock RAFT polymerization self assembly.

In this work, we synthesized a new comb-like copolymer (c-iMP) possessing amphiphilic diblock side chains consisting of poly(methyloxazoline) (PMOZ) and poly(phenyloxazoline) (PPOZ) via reversible addition-fragmentation chain-transfer (RAFT) polymerization of p-choloromethylstyene (CMS) and cationic ring-opening polymerization (CROP) of 2-methyl-2-oxazoline (MOZ) and 2-phenyl-2-oxazoline (POZ). Then, by performing selective hydrolysis of the hydrophilic PMOZ block, the PMOZ block was transformed into PEI (polyethylenimine) from which comb-like copolymers (c-iEP) possessing two blocks of PEI (E) and PPOZ (P) were produced. The comb-copolymers c-iEP showed unique self-assembling behavior in water to give an unusual polymersome covered by a loop-cluster polyamine corona. The polymersome showed extreme toughness and stability without collapse and fusion even at dry conditions and could be transformed into capsules. This is the first example of polymersome without free-ends on the vesicle wall which could include Ag ions inside and could deposit silica around the wall to form hybrid hollow spheres.

RSC Advances published new progress about Aggregates. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Product Details of C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wan, Zhuoya; Sun, Jingjing; Xu, Jieni; Moharil, Pearl; Chen, Jing; Xu, Junchi; Zhu, Junjie; Li, Jiang; Huang, Yixian; Xu, Pengfei; Ma, Xiaochao; Xie, Wen; Lu, Binfeng; Li, Song published the artcile< Dual functional immunostimulatory polymeric prodrug carrier with pendent indoximod for enhanced cancer immunochemotherapy>, Application of C9H9Cl, the main research area is cancer immunostimulatory anticancer agent doxorubicin indoximod tumor microenvironment immunity; Immuno-oncology; Immunochemotherapy; Indoleamine 2,3-dioxygenase; Indoximod.

Immunotherapy based on checkpoint blockade has been regarded as one of the most promising approaches towards many types of cancers. However, low response rate hinders its application due to insufficient tumor immunogenicity and immunosuppressive tumor microenvironment. To achieve an overall enhanced therapeutic outcome, we developed a dual-functional immuno-stimulatory polymeric prodrug carrier modified with pendent indoximod, an indoleamine 2,3-dioxygenase (IDO) inhibitor that can be used to reverse immune suppression, for co-delivery of Doxorubicin (Dox), a hydrophobic anticancer agent that can promote immunogenic cell death (ICD) and elicit antitumor immunity. The resulted carrier denoted as POEG-b-PVBIND, consisting of poly (oligo (ethylene glycol) methacrylate) (POEG) hydrophilic blocks and indoximod conjugated hydrophobic blocks, is rationally designed to improve immunotherapy by synergistically modulating the tumor microenvironment (TME). Our data showed that Dox-triggered ICD promoted intra-tumoral infiltration of CD8+ T cells and IFN-γ-production by CD8+ T cells. Meanwhile, cleaved indoximod significantly increased CD8+ T cell infiltration while reducing the immunosuppressive T regulatory cells (Tregs). More importantly, Dox/POEG-b-PVBIND micelles led to significantly improved tumor regression in an orthotopic murine breast cancer model compared to both Dox-loaded POEG-b-PVB micelles (a control inert carrier) and POEG-b-PVBIND micelles alone, confirming combination effect of indoximod and Dox in improving the overall antitumor activity. Indoleamine 2,3-dioxygenase (IDO) is an enzyme that can induce immune suppressive microenvironment in tumors. As a well-studied IDO inhibitor, indoximod (IND) represents a promising agent for cancer immunotherapy and could be particularly useful in combination with other chemotherapeutic agents. However, three major problems hinder its application: (1) IND is barely soluble in water; (2) IND delivery efficiency is limited (3) simultaneous delivery of two agents into tumor site is still challenging. Currently, most reports largely focus on improving the pharmacokinetic profile of IND alone via different formulations such as IND prodrug and IND nanocrystal. However, there is limited information about IND based co-delivery systems, especially for delivering hydrophobic chemotherapeutic agents. Here, we developed a new dual-functional polymeric prodrug carrier modified with a number of pendent IND units (denoted as POEG-b-PVBIND). POEG-b-PVBIND shows immunostimulatory and antitumor activities by itself. More importantly, POEG-b-PVBIND polymer is able to self-assemble into nano-sized micelles that are highly effective in formulating and codelivering other hydrophobic agents including doxorubicin (Dox), sunitinib (Sun), and daunorubicin (Dau), which can elicit antitumor immunity via promoting immunogenic cell death (ICD). We have shown that our new combination therapy led to a significantly improved antitumor activity in an aggressive murine breast cancer model (4T1.2).

Acta Biomaterialia published new progress about Animal organ. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Application of C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cazotti, Jaime C.; Fritz, Alexander T.; Garcia-Valdez, Omar; Smeets, Niels M. B.; Dube, Marc A.; Cunningham, Michael F. published the artcile< Grafting from Starch Nanoparticles with Synthetic Polymers via Nitroxide-Mediated Polymerization>, Reference of 1592-20-7, the main research area is grafting starch nanoparticle nitroxide mediated polymerization acrylic; grafting from; nitroxide-mediated polymerization; reversible deactivation radical polymerization; starch nanoparticles.

Nitroxide-mediated polymerization (NMP) is employed to graft synthetic polymers from polysaccharides. This work demonstrates the first successful polymer grafting from starch nanoparticles (SNPs) via NMP. To graft synthetic polymers from the SNPs’ surface, the SNPs are first functionalized with 4-vinylbenzyl chloride prior to reaction with BlocBuilder MA yielding a macroinitiator. Me methacrylate with styrene, acrylic acid, or Me acrylate are then grafted from the SNPs. The polymerizations exhibited linear reaction kinetics, indicating that they are well controlled. Thermal gravimetric anal. and spectroscopic techniques confirmed the synthesis of the precursors materials and the success of the grafting from polymerizations The incorporation of hydrophobic synthetic polymers on hydrophilic SNPs yields new hybrid materials that could find use in several industrial applications including paper coatings, adhesives, and paints.

Macromolecular Rapid Communications published new progress about Adhesives. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Reference of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jheng, Li-Cheng; Hsu, Chung-Yen; Yeh, Hong-Yi published the artcile< Anion Exchange Membranes Based on Imidazoline Quaternized Polystyrene Copolymers for Fuel Cell Applications>, Quality Control of 1592-20-7, the main research area is imidazoline quaternized polystyrene copolymer anion exchange membrane fuel cell; anion exchange membranes; fuel cells; imidazoline; polystyrene.

Imidazoline is a five-membered heterocycle derived by the partial reduction of one double bond of the imidazole ring. This work prepared new anion exchange membranes (AEMs) based on imidazoline quaternized polystyrene copolymers bearing N-β-hydroxyethyl oleyl imidazolinium pendent groups to evaluate the application potential for anion exchange membrane fuel cells (AEMFCs). For comparison, an imidazole quaternized polystyrene copolymer was also synthesized. The polymer chem. structure was confirmed by FTIR, NMR, and TGA. In addition, the essential properties of membranes, including ion exchange capacity (IEC), water uptake, and hydroxide conductivity, were measured. The alk. stabilities of imidazolium-based and imidazolinium-based AEMs were compared by means of the changes in the TGA thermograms, FTIR spectra, and hydroxide conductivity during the alk. treatment in 1M KOH at 60°C for 144 h. The results showed that the imidazolinium-based AEMs exhibited relatively lower hydroxide conductivity (5.77 mS/cm at 70°C) but much better alk. stability compared with the imidazolium-based AEM. The imidazolinium-based AEM (PSVBImn-50) retained 92% of its hydroxide conductivity after the alk. treatment. Besides, the fuel cell performance of the imidazolium-based and imidazolinium-based AEMs was examined by single-cell tests.

Membranes (Basel, Switzerland) published new progress about Anion exchange membranes. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Quality Control of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dashan, Irem; Balta, Demet Karaca; Temel, Binnur Aydogan; Temel, Gokhan published the artcile< Preparation of Single Chain Nanoparticles via Photoinduced Double Collapse Process>, Application In Synthesis of 1592-20-7, the main research area is chain nanoparticle photoinduced collapse.

A straightforward method is described to achieve polymeric nanoparticles by double folding of single linear chains. The side chain functional polystyrene with controlled mol. weight is converted to pendant azide and benzophenone motifs via postmodification reactions. Resulting functionalized chains undergo intramol. crosslinking upon UV illumination using simultaneous and subsequent pathways at a dilute concentration Particle size of nanoparticles can be tuned by changing the degree of crosslinking using a second folding process. Obtained single and double collapsed chains indicate higher glass transition temperatures and lower hydrodynamic radii compared to their intermediates. To our knowledge, the combination of photoinduced azide crosslinking and radical coupling processes is the first attempt to prepare double folding single polymer chains.

Macromolecular Chemistry and Physics published new progress about Crosslinking, intramolecular. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Application In Synthesis of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics