Ultrasensitive label-free electrochemical immunoassay of carbohydrate antigen 15-3 using dendritic Au@Pt nanocrystals/ferrocene-grafted-chitosan for efficient signal amplification was written by Wang, Ai-Jun;Zhu, Xiao-Yan;Chen, Yao;Luo, Xiliang;Xue, Yadong;Feng, Jiu-Ju. And the article was included in Sensors and Actuators, B: Chemical in 2019.Application of 122-18-9 The following contents are mentioned in the article:
The introduction of advanced nanocrystals and mediator is crucial for signal amplification of electrochem. immunosensors due to trace amounts of analytes in real samples. Herein, a novel ultrasensitive label-free electrochem. immunosensor was constructed to monitor carbohydrate antigen 15-3 (CA15-3) based on dendritic Au@Pt core-shell nanocrystals (Au@Pt NCs) uniformly dispersed with ferrocene-grafted-chitosan (Fc-g-CS), where Au@Pt NCs were prepared with hexadecyldimethyl benzyl ammonium chloride (HDBAC) as the growth-directing agent via a simple one-pot wet-chem. strategy. More notably, Fc grafted with CS would dramatically improve the stability and the Fc-g-CS enlarged sp. surface area and behaved as dispersing agent for the Au@Pt NCs to greatly boost the electrochem. signals and improve the biocompatibility. The resulting immunosensor displayed wider linear range of 0.5-200 U mL-1 and lower detection limit of 0. 17 U mL-1, which was further explored for detecting CA15-3 in serum sample with highly acceptable results. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Application of 122-18-9).
N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 122-18-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics