Category: 1186603-47-3

Gold-catalyzed [4+3]-Annulations of Benzopyryliums with Vinyldiazo Carbonyls to Form Bicyclic Heptatriene Rings with Skeletal Rearrangement was written by Sekar Kulandai Raj, Antony;Liu, Rai-Shung. And the article was included in Advanced Synthesis & Catalysis in 2020.Application of 1186603-47-3 The following contents are mentioned in the article:

Gold catalyzed [4+3]-annulations between benzopyryliums e.g., 2-(phenylethynyl)benzaldehyde and 3-alkyl-2-diazo-3-vinyl carbonyls RC(=CH₂)C(=N₂)C(O)R¹ (R = Me, n-Pr, n-Bu; R¹ = n-Bu, Ph, cyclohexyl), yielding 7H-benzo[7]annulene products e.g., I efficiently were reported. Notably, the carbon skeletons of resulting 7H-benzo[7]annulenes e.g., I are structurally rearranged, accompanied by migrations of their alkyl and ketone motifs. Apart from applicable substrates over a wide scope, these annulations are applicable to pyryliums and 3-alkyl-2-diazo-3-vinyl esters to increase their reaction significance. A mechanism involving an initial [4+2]-cycloaddition between benzopyryliums and 3-alkyl-2-diazo-3-vinyl carbonyl species, followed by formation of gold carbenes to induce a ring expansion and group migrations was postulated. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of substituted isoquinolines via iminoalkyne cyclization using Ag(I) exchanged K10-montmorillonite clay as a reusable catalyst was written by Jeganathan, Mariappan;Pitchumani, Kasi. And the article was included in RSC Advances in 2014.HPLC of Formula: 1186603-47-3 The following contents are mentioned in the article:

Monosubstituted isoquinolines were synthesized in good to excellent yields by the Ag(I)-exchanged K10-montmorillonite clay catalyzed ring closure of iminoalkynes. This silver catalyzed ring closure was highly effective in cyclizing aryl- and alkyl-substituted iminoalkynes at 100 ° and accommodated a variety of iminoalkynes, thus affording a convenient route to the synthesis of isoquinolines. The other salient features of this procedure were its reusability, environmentally benign nature, high yield, operational simplicity with fewer steps, easy separation and minimization of metallic wastes. The reaction proceeded smoothly in moderate yields and tolerated various functional groups. The solid catalyst was readily recovered and reused. Notably, no addnl. base or other co-catalysts were needed. A plausible mechanism was proposed in which isoquinolines were formed via simultaneous bifunctional acid-base catalysis by Ag(I) clay. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3HPLC of Formula: 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Light-Enabled Radical 1,4-Aryl Migration Via a Phospho-Smiles Rearrangement was written by De Abreu, Maxime;Belmont, Philippe;Brachet, Etienne. And the article was included in Journal of Organic Chemistry in 2021.Electric Literature of C15H9ClO The following contents are mentioned in the article:

Rearrangement reactions in organic chem. are attractive strategies to build efficiently complex scaffolds, in just one step, from simple starting materials. Among them, aryl migrations are certainly one of the most useful and straightforward rearrangement for building attractive C-C bonds. Of note, anionic aryl migration reactions were largely described compared to their radical counterparts. Recently, visible-light catalysis proved its efficiency to generate such radical rearrangements due to the concomitant loss of a particle (often CO₂ or SO₂), which is the driving-force of the reaction. Here, the authors disclose a Smiles-type rearrangement, triggered by a P-containing unit (arylphosphoramidate), therefore called phospho-Smiles rearrangement, allowing a Csp²-Csp² bond formation thanks to a 1,4-aryl migration reaction. Combining this approach with a radical hydroamination/amination reaction produces an amination/phospho-Smiles cascade particularly attractive, for instance, to study the synthesis of the phthalazine core, a scarcely described scaffold of interest for medicinal chem. projects. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Electric Literature of C15H9ClO).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Electric Literature of C15H9ClO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Stereospecific Synthesis of (Z,Z)-Isobenzofurans via Radical-Enabled Cleavage of C(sp³)-C(sp³) and C(sp²)-Halogen Bonds was written by Huang, Min-Hua;Shi, Hao-Nan;Zhu, Chi-Fan;He, Chun-Lan;Hao, Wen-Juan;Tu, Shu-Jiang;Jiang, Bo. And the article was included in Advanced Synthesis & Catalysis in 2019.Related Products of 1186603-47-3 The following contents are mentioned in the article:

A novel radical-induced annulation/1,8-halosulfonylation of β-alkynyl ketones I (X = CH; R¹ = Ph, 3-ClC₆H₄, 4-EtC₆H₄, etc.; R² = H, 5-F, 4-Cl, 5-Cl, 5-MeO) and I (X = N; R¹ = 4-ClC₆H₄; R² = H) with haloaryl diazonium tetrafluoroborates X¹C₆H₄N₂⁺BF₄^– (X¹ = 4-Cl, 4-Br, etc.) and DABCO·bis(sulfur dioxide) was first achieved via the cleavage/recombination of C(sp³)-C(sp³) and C(sp²)-halogen bonds, from which 47 examples of sulfone-containing 1,3-dimethylene-substituted (Z,Z)-isobenzofurans II as single stereoisomers were synthesized in generally good yields. This multicomponent pathway is proposed to proceed through the in-situ generation of arylsulfonyl radicals, followed by selective radical addition-cyclization and ring-opening of the cyclopropyl unit as well as C(sp²)-halogen bond cleavage, resulting in the consecutive construction of three new chem. bonds, including C-S, C-O and C-halogen bonds. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Related Products of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rapid access to substituted 2-naphthyne intermediates via the benzannulation of halogenated silylalkynes was written by Hein, Samuel J.;Lehnherr, Dan;Dichtel, William R.. And the article was included in Chemical Science in 2017.Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

Here a general synthetic strategy was reported to access 2-naphthyne precursors through an Asao-Yamamoto benzannulation of ortho-(phenylethynyl)benzaldehydes with halo-silylalkynes. This transformation provided 2-halo-3-(trimethylsilyl)-naphthalenes such as I [R¹ = H, n-Bu, Cl, etc.; R² = F, Cl, OC(O)C₅H₁₁, etc.; X = I, Br] with complete regioselectivity. These naphthalene products I underwent desilylation/dehalogenation in the presence of fluoride ion to generate the corresponding 2-naphthyne intermediates, as evidenced by furan trapping expts, which in turn afforded [2.2.1]oxabicyclic alkenes II [R¹ = R² = H, n-Bu, Cl; R¹ = Br, R² = H]. When these 2-naphthynes were generated in the presence of a copper catalyst, they underwent polymerization to afford ortho-naphthalene oligomers, 2,3,8,9,14,15-hexabutyltrinaphthylene and tetrabutylbinaphthalene III selectively by varying the catalyst loading and reaction temperature The efficiency, mild conditions and versatility of the naphthalene products and naphthyne intermediates will provide efficient access to many new functional aromatic systems. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Completely Stereoselective Synthesis of Sulfonated 1,3-Dihydroisobenzofurans via Radical Multicomponent Reactions was written by Shi, Hao-Nan;Huang, Min-Hua;He, Chun-Lan;Lu, Hai-Ping;Hao, Wen-Juan;Tu, Xing-Chao;Tu, Shu-Jiang;Jiang, Bo. And the article was included in Journal of Organic Chemistry in 2019.Name: 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

Two types of new oxidant-free radical multicomponent reactions of β-alkynyl ketones, aryldiazonium salts, and DABCO·(SO₂)₂ (DABSO) were established, leading to the tunable generation of two class of sulfonated 1,3-dihydroisobenzofurans with moderate to good yields and complete stereoselectivity under the mild conditions. The radical-induced scission/recombination of the C(sp³)-C(sp³) bond enabled direct 1,8-halosulfonylation of β-alkynyl ketones, giving 1,3-dimethylene-substituted (1Z,3Z)-1,3-dihydroisobenzofurans with substituent diversity by p-nitrobenzyl bromide (PNBB) or p-nitrobenzyl chloride (PNBC) as the halo source. Fine-tuning substituents to strong electron-withdrawing ones, such as nitro, cyano, and trifluoromethyl, linked to aryldiazonium tetrafluoroborates allowed a different annulation/1,5-azosulfonylation process to access sulfonated (Z)-1,3-dihydroisobenzofurans with one quaternary carbon-amino functionality. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Name: 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and applications of fluoride probe based on aromatization of isoquinolinium salts was written by Zhao, Yun-Hui;Yu, Yajun;Guo, Tao;Zhou, Zhihua;Tang, Zilong;Tian, Li. And the article was included in Dyes and Pigments in 2020.Formula: C15H9ClO The following contents are mentioned in the article:

A novel ratiometric fluorescent probe based on aromatization drive of isoquinolinium salts was designed, synthesized to recognize fluoride. The applications showed that the probe has high selectivity and sensitivity to fluoride. Fluoride induces a cascade reaction of hydroxyl deprotection and 1,6-oxidative elimination, and causes a remarkable fluorescence enhancement. The relative fluorescent intensities (I₃₉₈/I₅₂₂) increased linearly with F^– concentration at 0-9.0μmol L^-1. The limit of detection was very low (3.7 nM) due to the intrinsic aromatization drive of probe induced by F^–. The recognition mechanism was demonstrated by mass spectrum (MS) and ¹H NMR. The in vitro imaging results showed that the new probe BIQS (2-[4-(tert-butyl-diphenyl-silyloxy)-benzyl]-3-(4-methoxy- phenyl) -isoquinolinium nitrate) was membrane-permeable and could be applied into the determination of fluoride ions in living cells. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Formula: C15H9ClO).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C15H9ClO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Functionalized Benzo[g]indoles and 1-Naphthols via Carbon-Carbon Triple Bond Breaking/Rearranging was written by Wang, Jia-Yin;Zhou, Peng;Li, Guigen;Hao, Wen-Juan;Tu, Shu-Jiang;Jiang, Bo. And the article was included in Organic Letters in 2017.Application of 1186603-47-3 The following contents are mentioned in the article:

Novel carbon-carbon triple bond breaking and rearranging reactions of benzene-linked allene-ynes have been established. The reactions can be selectively controlled toward the formation of two families of skeletally diverse benzo[g]indoles I (R¹ = H, 8-F, 7-Cl, 8-Me; R² = Ph, 4-MeC₆H₄, 4-EtC₆H₄, 3-MeC₆H₄, 2-ClC₆H₄, etc.) and 1-naphthols II (X = Br, Cl; R = H, 6-Cl, 6-MeO; R¹ = Ph, 4-MeC₆H₄, 4-EtC₆H₄, 4-FC₆H₄, 4-ClC₆H₄, etc.) under mild conditions. Silver salt was found to efficiently promote indole annulation to give multifunctional benzo[g]indoles with the installation of two sulfonyl groups into the indole ring via N-S and N-F bond cleavage of NFSI, whereas NBS and NCS-mediated benzannulations occurred with the formation of dihalogenated 1-naphthols. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Functionalized Cyclobutane-Fused Naphthalene Derivatives via Cascade Reactions of Allenynes with tert-Butyl Nitrite was written by Feng, Tian;He, Yan;Zhang, Xinying;Fan, Xuesen. And the article was included in Advanced Synthesis & Catalysis in 2019.Name: 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

A novel synthesis of cyclobutanol-fused 2-nitronaphthalen-1-ols I [R¹ = H, 6-Cl, 7-Me, 7-OCH₃; R² = Ph, 4-ClC₆H₄, thiophen-3-yl, etc.] and nitrocyclobutane-fused naphthalene-1,2-diones II [R³ = H, Et, C(O)OC₂H₅; R⁴ = H, Cl, F, OCH₃; R⁵ = H, F, OCH₃, Me; R⁶ = H; R⁵R⁶ = -CH=CH-CH=CH-] through cascade reactions of benzene-linked allenynes 2-(CCR²)-3-(R⁶)-4-(R⁵)-5-(R⁴)-C₆HC(O)CH=C=CHR³ with tert-Bu nitrite is presented. The formation of the title compounds I and II involves a tandem process including allenyne [2+2] cycloaddition, radical addition onto the in situ formed cyclobutenyl moiety followed by radical coupling/oxidation Interestingly, different kinds of functionalized naphthalene derivatives could be obtained selectively from the same substrates, and the selectivity was easily controlled by finely tuning the reaction conditions. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Name: 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Unraveling innate substrate-controlled arylation and bicyclization of 1,5-enynes with α,β conjugates: synthesis of substituted benzo[a]fluorenes was written by Gore, Babasaheb Sopan;Lin, Jun-Hao;Wang, Jeh-Jeng. And the article was included in Green Chemistry in 2021.HPLC of Formula: 1186603-47-3 The following contents are mentioned in the article:

A strategy for the aromatic C-H functionalization of electron-rich arenes, such as anisole, phenol, veratrol, toluene or naphthalene, with 1,5-enynes anchored by conjugates, e.g., I (X = CN, EtO₂C, Ts, PhCO; R¹ = n-Bu, Ph, 3-FC₆H₄, etc.; R² = H, 4-Me, 5-F, 4-MeO, etc.; R³ = H, 4-Cl, 3-F, 3-Br, etc.) catalyzed by a Bronsted acid under metal- and solvent-free conditions has been developed. A diverse range of benzo[a]fluorenes, e.g., II [R⁴ = 4-MeOC₆H₄, 4-HOC₆H₄, 3,4-(MeO)₂C₆H₃] [from I (X = CN)] or III (R⁴ = 4-MeOC₆H₄, 4-MeC₆H₄, 1-naphthyl), was obtained in moderate to good yields by using this protocol. This process includes intermol. nucleophilic arene insertion or 6-exo-dig cyclization (depending on the nature of the substrates) followed by a Friedel-Crafts-type reaction and 1,5-H transfer or intermol. nucleophilic arene insertion, resp. In addition, reactions with heterocyclic compounds such as (E)-2-benzoyl-3-(2-(phenylethynyl)pyridin-3-yl)acrylonitrile proceeded smoothly and afforded 11-phenyl-11H-indeno[1,2-h]quinoline-6-carbonitrile. Moreover, solvent recycling experiments were successfully carried out to illustrate green pathways. These reactions feature a readily accessible starting materials, transition metal-free approaches, simple one-pot operations, gram-scale syntheses and wide functional group tolerance. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3HPLC of Formula: 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics