Category: 1186603-47-3

Silver-catalyzed C-C bond formation with carbon dioxide: significant synthesis of dihydroisobenzofurans was written by Sekine, Kohei;Takayanagi, Ayano;Kikuchi, Satoshi;Yamada, Tohru. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2013.Computed Properties of C15H9ClO The following contents are mentioned in the article:

The silver salt catalyzed the C-C bond forming reaction of o-alkynylacetophenone derivatives and carbon dioxide. In this reaction, a carbonyl group and a furan skeleton were successively constructed to afford the corresponding dihydroisobenzofuran derivatives This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Computed Properties of C15H9ClO).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C15H9ClO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Silver triflate-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and α,β-unsaturated carbonyl compound was written by Ye, Shengqing;Yang, Xiaodi;Wu, Jie. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2010.Quality Control of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

A highly efficient silver triflate-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and α,β-unsaturated carbonyl compound is reported, which affords H-pyrazolo[5,1-a]isoquinoline-1-carboxylates, e.g., I in good yield. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Quality Control of 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gold-Catalyzed Ring Expansion of Enyne-Lactone: Generation and Transformation of 2-Oxoninonium was written by Luo, Kui;Cao, Tongxiang;Jiang, Huanfeng;Chen, Lianfen;Zhu, Shifa. And the article was included in Organic Letters in 2017.Application of 1186603-47-3 The following contents are mentioned in the article:

An efficient gold-catalyzed ring-expansion reaction of enyne-lactones to form 2-oxoninonium intermediates is reported. The 2-oxoninonium generated in this work could undergo further 6π electrocyclization and aromatization reaction to produce different aromatic compounds This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Potential Anticancer 1-(1H-Indol-3-yl)isoquinolines by Silver Nitrate Mediated Tandem Reactions of 2-Alkynylbenzaldehyde Azines and Indoles was written by Zhao, Yun-Hui;Luo, Yueyang;Zhu, Yingli;Wang, Hang;Zhou, Hangbin;Tan, Hailong;Zhou, Zhihua;Ma, Yong-Cheng;Xie, Wenlin;Tang, Zilong. And the article was included in Synlett in 2018.Application of 1186603-47-3 The following contents are mentioned in the article:

Novel antitumor compounds featuring isoquinoline and indole moieties were synthesized by a silver nitrate promoted domino reaction involving intramol. cyclization, nucleophilic addition of indole and subsequent N-N bond cleavage. The transformation from readily available starting materials into an interesting class of indole-substituted isoquinolines was completed under mild conditions and by simple operations in moderate to good yields. The antitumor activity of these compounds in-vitro was significantly greater than that of a reference compound, 5-fluorouracil. The products might serve as new lead compounds for drugs for the treatment of cancer. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper-Catalyzed [4+2]-Cycloadditions of Isoxazoles with 2-Alkynylbenzaldehydes To Access Distinct α-Carbonylnaphthalene Derivatives: C(3,4)- versus C(4,5)-Regioselectivity at Isoxazoles was written by Giri, Sovan Sundar;Liu, Rai-Shung. And the article was included in ACS Catalysis in 2019.Name: 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

Cu(II)-catalyzed [4+2]-cycloadditions occur between Cu-benzopyryliums and substituted isoxazoles with the regioselectivity on the C(3,4)-carbons of isoxazoles. We postulate that a prior coordination of isoxazoles with Cu(OAc)₂ increases the π-bond character of the C(3,4) carbons to become an effective 2π-donor. In this reaction sequence, 3,5-disubstituted isoxazoles yield α,γ-dicarbonylnaphthalenes whereas, 5-substituted isoxazoles deliver α,γ-dicarbonyl-β-aminonaphthalenes. For unsubstituted isoxazole, its cycloaddition chemoselectivity is switched to the C(4,5)-addition regioselectivity to yield α-carbonyl-γ-cyanonaphthalene derivatives This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Name: 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

De Novo Protocol for the Construction of Benzo[a]fluorenes via Nitrile/Alkene Activation was written by Gore, Babasaheb Sopan;Chiang, Chun-Hsien;Lee, Chein Chung;Shih, Yi-Lun;Wang, Jeh-Jeng. And the article was included in Organic Letters in 2020.Computed Properties of C15H9ClO The following contents are mentioned in the article:

Unprecedented chemo- and regioselective synthesis of benzo[a]fluorenes and naphthamide-substituted benzo[a]fluorenes were constructed from the reaction of (E)-2-aroyl-3-(2-(arylalkynes/alkenes)aryl)acrylonitrile scaffolds under metal-free conditions via the activation of nitriles and alkenes, resp. A tentative reaction mechanism was proposed for this homofunctionalization of nitriles. Control experiments showed that the reaction proceeds via selective nitrile or alkene protonation, depending upon the substrates. Addnl., we demonstrated an alternative expeditious route for the synthesis of disubstituted benzo[a]fluorenes in the presence of TfOH alone. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Computed Properties of C15H9ClO).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C15H9ClO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper-catalyzed annulation- cyanotrifluoromethylation of 1,6-enynes toward 1-indanones via a radical process was written by Zhang, Tian-Shu;Hao, Wen-Juan;Cai, Pei-Jun;Li, Guigen;Tu, Shu-Jiang;Jiang, Bo. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2020.Reference of 1186603-47-3 The following contents are mentioned in the article:

A new Cu(II)-catalyzed annulation-cyanotrifluoromethylation of 1,6-enynes with Togni′s reagent and trimethylsilyl cyanide (TMSCN) has been established, enabling the direct construction of trifluoromethylated 1-indanones with an all-carbon quaternary center in good yields. This reaction was performed by using low-cost Cu(OTf)₂ as the catalyst and Togni′s reagent as both the radical initiator and a CF₃ source, providing an efficient protocol for building up an 1-indanone framework with wide functional group compatibility. The reaction mechanism was proposed through a radical triggered addition/5-exo-dig cyclization/oxidation/nucleophilic cascade. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Reference of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bronsted Acid-Promoted One-Pot Synthesis of Chrysene Derivatives via Isochromenylium Intermediate Formed in Situ was written by Guo, Biao;Zhou, Yiming;Zhang, Lei;Hua, Ruimao. And the article was included in Journal of Organic Chemistry in 2015.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

Trifluoromethanesulfonic acid (HOTf) promoted cross-coupling of ortho-[2-(4-methoxylphenyl)-alkynyl]acetophenones with ortho-alkynylbenzaldehydes affording chrysene derivatives I (R¹ = H, 2-F, 2-Cl, 2-Me, 3-F, etc.; R² = H, 3-Cl, 3-Me, 3-OMe, 2-F, 2-Cl, 1-F, etc.; R³ = H, Ph, 4-MeC₆H₄, 4-FC₆H₄, 4-ClC₆H₄) has been developed. The present cascade reaction provides a facile one-pot synthesis of multisubstituted chrysenes as well as naked chrysene under mild conditions. The mechanism exptl. results demonstrate isochromenylium is a key intermediate for this transformation. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

DBU/AgOTf Relay-Catalysis Enabled One-Pot Synthesis of 1,3-Dihydroisobenzofurans and Its Conversion to Indanones was written by Wang, Jiazhuang;Huang, Hongtai;Gao, Haotian;Qin, Guiping;Xiao, Tiebo;Jiang, Yubo. And the article was included in Advanced Synthesis & Catalysis in 2022.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

A DBU/AgOTf relay-catalyzed one-pot reaction of 2-alkynylbenzaldehydes and α-diazo esters for the efficient construction of 1,3-dihydroisobenzofuran derivatives was documented. This protocol can tolerate a wide range of substrates and its scalability was demonstrated by the gram-scale reaction. Moreover, the obtained 1,3-dihydroisobenzofurans were converted to indanone derivatives by a AgOTf-catalyzed ring recombination process. Both of the resulting products, 1,3-dihydroisobenzofurans and indanones, are important structural units of a variety of pharmaceuticals and natural products, and their structures are clearly confirmed by single crystal X-ray diffraction anal. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Category: chlorides-buliding-blocks).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An efficient synthesis of 6-benzyl-2-arylthieno[2,3-d]pyrimidin-4(3H)-ones catalyzed by HCl involving a Friedel-Crafts alkylation reaction was written by Pan, Wan-Chen;Wang, Yi-Chun;Li, Tuan-Jie;Liu, Jian-Quan;Wang, Xiang-Shan. And the article was included in Journal of Heterocyclic Chemistry in 2020.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

Aldehydes could underwent not only the subsequent condensation and cyclization with 2-aminothiophene-3-carboxamides to build a pyrimidine ring, but also a Friedel-Crafts alkylation reaction with thiophene moiety to gave unexpected 6-benzyl-2-arylthieno[2,3-d]pyrimidin-4(3H)-ones I [R¹ = H, Cl, F, Me, MeO; R² = H, Cl, F, MeO; Ar = Ph, 4-MeC₆H₄, 4-EtC₆H₄, 4-n-PrC₆H₄, 4-ClC₆H₄] and II [R³ = 2-MeOC₆H₄, 2-Br-4-FC₆H₃, 2-furyl, etc.] in good yields catalyzed by concentrated HCl. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics