Category: 1186603-47-3

Isoquinolone synthesis via Zn(OTf)₂-catalyzed aerobic cyclocondensation of 2-(1-alkynyl)-benzaldehydes with arylamines was written by Khan, Dost Muhammad;Hua, Ruimao. And the article was included in Catalysts in 2020.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

A zinc(II) triflate-catalyzed cyclocondensation of ortho-alkynylbenzaldehydes with arylamines was developed in the presence of base under an oxygen atm. and afforded isoquinolones in good to high yields. The advantages of the present catalyst system include the use of an air-stable and cheap com. available Lewis acid as the catalyst, high atom utilization and easily available starting materials. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Study on the iodine-catalyzed reaction of 3-aminopyrazine-2-carbohydrazide and 2-(arylethynyl)benzaldehydes was written by Pan, Wan-Chen;Liu, Jian-Quan;Wang, Xiang-Shan. And the article was included in Tetrahedron in 2018.Reference of 1186603-47-3 The following contents are mentioned in the article:

At 60°C in DMSO, the iodine-catalyzed reaction of 3-aminopyrazine-2-carbohydrazide and 2-(arylethynyl)benzaldehydes led hydrazones. Increasing the reaction temperature to 100°C, the amino and amido still indicated inactive, only the imine took part in the addition of acetylene bond to give 2-arylisoquinolines in high yields with the cleavage of N-N bond unexpectedly under metal-free conditions. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Reference of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of H-Pyrazolo[5,1-a]isoquinolines via Copper(II)-Catalyzed Oxidation of an Aliphatic C-H Bond of Tertiary Amine in Air was written by Li, Shaoyu;Wu, Jie. And the article was included in Organic Letters in 2011.Formula: C15H9ClO The following contents are mentioned in the article:

A multicomponent reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and tertiary amine is discovered, which generates the unexpected H-pyrazolo[5,1-a]isoquinolines, e.g., I in good yields under mild conditions. In the reaction process, silver(I)-catalyzed intramol. cyclization and copper(II)-catalyzed oxidation of an aliphatic C-H bond of tertiary amine in air are involved. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Formula: C15H9ClO).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C15H9ClO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An efficient approach to isoquinoline via AgNO₃-promoted 6-endo-dig cyclization followed by oxidative elimination of o-alkynylarylaldimines and its application in fluoride recognition was written by Tang, Yongxing;Yu, Yajun;Wei, Xinyu;Yang, Jin;Zhu, Yeting;Zhao, Yun-Hui;Tang, Zilong;Zhou, Zhihua;Li, Xiaofang;Yu, Xianyong. And the article was included in Tetrahedron Letters in 2019.Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

A novel 6-endo-dig cyclization followed by oxidation/elimination of o-alkynylbenzaldehydes with 4-hydroxybenzylamine was developed for preparation of isoquinolines. The intermediates of this tandem reaction were monitored by mass spectroscopy (MS) to confirm the reaction pathway. This methodol. was further applied to the design and synthesis of a novel ratiometric chemosensor for determination of fluoride. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalytic Asymmetric Tandem Reaction of o-Alkynylbenzaldehydes, Amines, and Diazo Compounds was written by Wu, Wei;Liao, Na;Wei, Qi;Huang, Jiaying;Huang, Qi;Peng, Yungui. And the article was included in Organic Letters in 2021.Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

An efficient asym. tandem reaction of o-alkynylbenzaldehydes, amines, and diazo compounds catalyzed by chiral silver imidodiphosphate has been established. Chiral 1,2-dihydroisoquinoline analogs have a tertiary stereocenter at the C1 position, and substituents at the C3 position are available with up to 97% yields and 98% ee. These products can be elaborated into the corresponding β-aminophosphonates or PARP1-inhibitor analogs. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tandem Construction of Indole-Fused Phthalazines from (2-Alkynylbenzylidene)hydrazines under Metal-Free Conditions was written by Shi, Zhaojiang;Wang, Lianhui;Yang, Zi;Jie, Lianghua;Liu, Xiao;Cui, Xiuling. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

An efficient approach to invent diversely substituted indole-fused phthalazines from in situ formed (2-alkynylbenzylidene)hydrazines under metal-free conditions via selective radical cyclization has been developed. Notably, this 6-exo-dig addition-cyclization tandem procedure proceeds under air atm. and shows a broad substrate suitability, as well as avoids harmful byproducts, which complies with the concept of green synthesis. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper Catalyzed Enantioselective Alkylation of Pyrrole with β,γ-Unsaturated α-Ketoesters: Application to One-Pot Construction of the Seven-Membered Ring by Merging a Gold Catalysis was written by Hu, Yanbin;Li, Yanan;Zhang, Sheng;Li, Chong;Li, Lijun;Zha, Zhenggen;Wang, Zhiyong. And the article was included in Organic Letters in 2015.Synthetic Route of C15H9ClO The following contents are mentioned in the article:

A highly enantioselective Friedel-Crafts alkylation of pyrrole to β,γ-unsaturated α-ketoesters was developed by virtue of a chiral copper complex, affording the alkylated derivatives of pyrrole with good yields and excellent enantioselectivities. Moreover, merging copper catalysis with gold catalysis realized a one-pot construction of the seven-membered ring to give annulated pyrroles with moderate to good yields and high enantiomeric excesses. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Synthetic Route of C15H9ClO).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C15H9ClO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cobalt-catalyzed regioselective syntheses of indeno[2,1-c]pyridines from nitriles and diynes bearing propargyl fragments was written by Xu, Murong;Zheng, Zhong;Wang, Mengdan;Kong, Lingkai;Ao, Yujuan;Li, Yanzhong. And the article was included in Organic & Biomolecular Chemistry in 2018.Reference of 1186603-47-3 The following contents are mentioned in the article:

A highly efficient CoI₂/o-phenanthroline catalyzed cycloaddition reaction of diynes bearing TBS protected propargylic alc. fragments with nitriles has been developed. This methodol. offers regioselective access, with good functional group tolerance, to various indeno[2,1-c]pyridine derivatives in moderate to excellent yields. It was found that o-phenanthroline as a bidentate nitrogen ligand showed high efficacy in this cycloaddition reaction. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Reference of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient Synthesis of Isoquinolines by AgNO₃-Catalyzed Tandem Imination Annulation of 2-Alkynyl Aldehydes with Ammonium Bicarbonate was written by Zhao, Yunhui;Luo, Mingjian;Li, Yubo;Liu, Xiong;Tang, Zilong;Deng, Keqin;Zhao, Gang. And the article was included in Chinese Journal of Chemistry in 2016.Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

A simple approach for the tandem synthesis of isoquinolines I [R¹ = H, 7-Me, 6-F, 7-OMe, 7-Cl; R² = H, Me, n-Bu, etc.] by the reaction of o-alkynylaldehydes with ammonium bicarbonate via silver nitrate-catalyzed tandem imination-annulation reaction was described. The reaction conditions and the scope of the reaction were examined and a variety of substituted isoquinolines were prepared in moderate to excellent yields. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 2,3,4,11b-tetrahydro-1H-pyridazino[6,1-a]isoquinolines via the three-component reaction of 2-alkynylbenzaldehydes, a sulfonylhydrazide and dimethyl cyclopropane-1,1-dicarboxylate was written by Yu, Xingxin;Qiu, Guanyinsheng;Liu, Jianping;Wu, Jie. And the article was included in Synthesis in 2011.COA of Formula: C15H9ClO The following contents are mentioned in the article:

A three-component reaction of 2-alkynylbenzaldehydes, a sulfonylhydrazide and di-Me cyclopropane-1,1-dicarboxylate, co-catalyzed by silver(I) triflate and nickel(II) perchlorate hexahydrate, is described, which affords 2,3,4,11b-tetrahydro-1H-pyridazino[6,1-a]isoquinolines, e.g. I (R = H, F, Cl, O₂N), in moderate to good yields. A possible reaction pathway that proceeds via a tandem 6-endo-cyclization and [3 + 3] cycloaddition sequence is proposed. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3COA of Formula: C15H9ClO).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C15H9ClO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics