Category: 118-45-6

Verbicky, John W. Jr.; Dellacoletta, Brent A.; Williams, Louella published the artcile< Palladium catalyzed decarbonylation of aromatic acyl chlorides>, Safety of 5-Chloroisobenzofuran-1,3-dione, the main research area is chlorophthalic anhydride; trimellitic anhydride acid chloride decarbonylation; decarbonylation aroyl chloride palladium catalyst; benzoyl chloride decarbonylation palladium catalyst; chlorobenzene.

At 265-360°, a variety of aromatic acyl chlorides can be rapidly decarbonylated to the corresponding aromatic chlorides in the gas phase or in the melt in moderate-to-excellent yield using 5% Pd/C, Pd(PPh3)4, or PdCl2 as a catalyst. E.g., trimellitic anhydride acid chloride in the melt with 5% Pd/C at 310° for 2 h gave 100% 4-chlorophthalic anhydride. 4-RC6H4COCl (R = H, Cl, CN, MeO, Me) with 5% Pd/C at 360° (gas phase) gave 18-98% 4-RC6H4Cl (R as before).

Tetrahedron Letters published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Safety of 5-Chloroisobenzofuran-1,3-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Verbicky, John W. Jr.; Dellacoletta, Brent A.; Williams, Louella published the artcile< Palladium catalyzed decarbonylation of aromatic acyl chlorides>, Safety of 5-Chloroisobenzofuran-1,3-dione, the main research area is chlorophthalic anhydride; trimellitic anhydride acid chloride decarbonylation; decarbonylation aroyl chloride palladium catalyst; benzoyl chloride decarbonylation palladium catalyst; chlorobenzene.

At 265-360°, a variety of aromatic acyl chlorides can be rapidly decarbonylated to the corresponding aromatic chlorides in the gas phase or in the melt in moderate-to-excellent yield using 5% Pd/C, Pd(PPh3)4, or PdCl2 as a catalyst. E.g., trimellitic anhydride acid chloride in the melt with 5% Pd/C at 310° for 2 h gave 100% 4-chlorophthalic anhydride. 4-RC6H4COCl (R = H, Cl, CN, MeO, Me) with 5% Pd/C at 360° (gas phase) gave 18-98% 4-RC6H4Cl (R as before).

Tetrahedron Letters published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Safety of 5-Chloroisobenzofuran-1,3-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jin, Zai-Su; Wang, Wen-Xi; Hu, Wei-Xiao; Yang, Zhong-Yu; Chen, Hong-Wei; Xuan, Ri-Cheng published the artcile< 5-Chloro-2-benzofuran-1,3-dione>, Application In Synthesis of 118-45-6, the main research area is mol structure chlorobenzofurandione; crystal structure chlorobenzofurandione; hydrogen bonding chlorobenzofurandione.

The asym. unit of the title compound, C8H3ClO3, contains two mols. The mol. packing is controlled by C-H…O H bonding. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application In Synthesis of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rao, K. Sudarsana; Veeranagaiah, V.; Ratnam, C. V. published the artcile< Structure of phthalamic acids from 4-substituted phthalic anhydrides and aromatic amines>, Application of C8H3ClO3, the main research area is phthalamic acid; decarboxylation phthalamic acid; anhydride phthalic aniline.

Phthalamic acids (I, R = Ph, R1 = Cl; R = Ph, R1 = NO2) were prepared by treatment of the corresponding phthalic anhydride with PhNH2. I were decarboxylated by copper oxide and quinoline to 4-R1C6H4CONHR.

Current Science published new progress about 118-45-6. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application of C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mathias, L. J.; Cei, G.; Johnson, R. A.; Yoneyama, M. published the artcile< Poly(thioether imide)s via chloro-displacement polymerization>, Formula: C8H3ClO3, the main research area is polyimide polythioether preparation property; thermal property polyimide polythioether; solubility polyimide polythioether.

Thioether containing polyimides were prepared by displacement of Cl from substituted imides by aromatic and aliphatic sulfur nucleophiles. The all-aromatic monomers and polymers had poor solubility which led to precipitation during synthesis and low mol. weight polymers. However, these polymers were thermally stable to 400° and had Tg 212-233°. The polymers prepared from 1,3-propanedithiol or bis(2-mercaptoethyl) sulfide had good solubility, but lower thermal stability, showing TGA loss onset temperatures of 297° and 298°, resp.

Polymer Bulletin (Berlin) published new progress about Glass transition temperature. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Formula: C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Guowei; Yang, Yaqing; Yang, Yanming; Song, Gao; Li, Shanshan; Zhang, Jiajun; Yang, Weimin; Wang, Liang-Liang; Weng, Zhiying; Zuo, Zhili published the artcile< The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation>, Category: chlorides-buliding-blocks, the main research area is adenylate cyclase agonist virtual screening cyclic adenosine monophosphate IL6; Adenylate cyclase; Agonist; Cyclic adenosine monophosphate; Interleukin-6; Virtual screening.

Adenylate cyclases (ACs), play a critical role in the conversion of ATP (ATP) into the second messenger cyclic adenosine monophosphate (cAMP). Studies have indicated that adenylyl cyclase type 2 (AC2) is potential drug target for many diseases, however, up to now, there is no AC2-selective agonist reported. In this research, docking-based virtual screening with the combination of cell-based biol. assays have been performed for discovering novel potent and selective AC2 agonists. Virtual screening disclosed a novel hit compound 8 as an AC2 agonist with EC50 value of 8.10μM on recombinant human hAC2 + HEK293 cells. The SAR (structure activity relationship) based on the derivatives of compound 8 was further explored on recombinant AC2 cells and compound 73 was found to be the most active agonist with the EC50 of 90 nM, which is 160-fold more potent than the reported agonist Forskolin and could selectively activate AC2 to inhibit the expression of Interleukin-6. The discovery of a new class of AC2-selective agonists would provide a novel chem. probe to study the physiol. function of AC2.

European Journal of Medicinal Chemistry published new progress about Drug screening (docking-based virtual screening). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Luxiao; Zhang, Hong-Yu; Yin, Guohui; Zhang, Yuecheng; Zhao, Jiquan published the artcile< Synthesis of N-unsubstituted cyclic imides from anhydride with urea in deep eutectic solvent (DES) choline chloride/urea>, Application In Synthesis of 118-45-6, the main research area is cyclic imide green preparation.

N-Unsubstituted cyclic imides, e.g., I were synthesized in deep eutectic solvent (DES) choline chloride (ChCl)/urea from anhydrides with urea. Urea served as both a DES component and a nitrogen source, which endowed the protocol with advantages of smooth reaction, easy separation of products, simple recovery and recycling of ChCl/urea.

Chemical Papers published new progress about Anhydrides, cyclic Role: RCT (Reactant), RACT (Reactant or Reagent). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application In Synthesis of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fertel, Lawrence B.; Spohn, Ronald F.; O’Reilly, Neil J.; Lin, Henry C. published the artcile< Aromatization of halogenated tetrahydrophthalic anhydrides with activated carbon. An effective preparation of 4,5-dichlorophthalic anhydride>, Formula: C8H3ClO3, the main research area is aromatization halogenated tetrahydrophthalic anhydride activated carbon; phthalic anhydride halogenated; dehydrogenation halotetrahydrophthalic anhydride activated carbon.

Halogenated tetrahydrophthalic anhydrides I (R = H, Cl) can be aromatized to phthalic anhydrides II by using activated carbon in 1,2,4-trichlorobenzene. Halogenated tetrahydrophthalic anhydrides I (R = H, Cl) can be aromatized to phthalic anhydrides II by using activated carbon in 1,2,4-trichlorobenzene.

Synlett published new progress about Aromatization. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Formula: C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Jiangtao; Chen, Guofei; Fang, Xingzhong published the artcile< Synthesis and characterization of high performance poly(thioether imide)s via aromatic nucleophilic substitution reaction of isomeric AB-type monomers>, HPLC of Formula: 118-45-6, the main research area is polyimide polythioether synthesis property.

A series of isomeric poly(thioether imide)s (PTIs) containing thioether linkages were prepared by aromatic nucleophilic substitution reaction of isomeric N-(4-mercaptophenyl)-3-chlorophthalimide and/or N-(4-mercaptophenyl)-4-chlorophthalimide. The inherent viscosities of these polymers were in the range of 0.38-0.42 dL/g. The glass transition temperature increased with increasing the content of 3-substituted phthalimide unit in the polymer backbone. The 5 % weight loss temperatures of isomeric PTIs (a-e) were 506-531° in nitrogen and 509-536° in air, resp. The isomeric PTIs (b-d) films exhibited good mech. properties with tensile strength of about 90 MPa, elongation at break of more than 6.0 %, and tensile moduli of more than 2.2 GPa. The storage moduli of PTIs (b-d) almost completely maintained at about 2.0 GPa before reaching the corresponding glass transition temperatures It is noted that the min. melt viscosity of these polymers decreased with increasing the content of unsym. 3- and 4-substituted phthalimide unit.

Polymer Bulletin (Heidelberg, Germany) published new progress about Elongation at break. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, HPLC of Formula: 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Tianming; Yao, Zhengjun; Zhou, Jintang published the artcile< Preparation and characterization of a novel composite of polythioetherimide/bismaleimide/2,2'-diallylbisphenol A>, COA of Formula: C8H3ClO3, the main research area is polythioetherimide bismaleimide diallylbisphenol composite preparation thermomech property.

A novel composite of polythioetherimide (PTEI)/bismaleimide (BMI)/2,2′-diallylbisphenol A (BA) was prepared Mech. measurements, dynamic thermomech. anal., and microanal. were conducted to assess the toughness and morphol. of the composite. Results demonstrate that the addition of PTEI has significant effects on the mech. properties of the BMI/BA system. Compared with the BMI/BA resin, the PTEI/BMI/BA system significantly improves the impact strength and bending strength, given an appropriate amount of PTEI. Scanning electron microscope (SEM) images and energy dispersive spectroscopy results show that PTEI is distributed uniformly in the PTEI/BMI/BA system and that the interfacial compatibility between the PTEI and BMI/BA phase is excellent. Thermogravimetric and dielec. analyses were also conducted to infer the thermal and dielec. properties of the composite. With a suitable addition of PTEI, the BMI/BA resin still exhibits good thermal resistance and dielec. constant and loss values of the blends still retain good stability in a frequency band from 10 MHz to 60 MHz. All these changes in properties are closely correlated with the addition of PTEI.

High Performance Polymers published new progress about Bending strength. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, COA of Formula: C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics