Category: 112-26-5

112-26-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112-26-5 name is 1,2-Bis(2-chloroethoxy)ethane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A suspension of4.5 g (14 mmol) of 2-diphenylphosphorylmethylphenol[12] and 0.56 g (14 mmol) of finely divided NaOHin 35 mL of dry dioxane was stirred for 0.5 h at 95C,next 1.3 g (7 mmol) of 1,8-dichloro-3,6-dioxaoctanewas added, the mixture was refluxed for 8 h, concentratedunder reduced pressure, 50 mL of water wasadded to the residue, the mixture was acidified withconcentrated HCl to pH 1 and extracted with CHCl3(3 ¡Á 25 mL). The extract was washed with diluted (1 : 2)HCl (2 ¡Á 30 mL), water (2 ¡Á 30 mL), and concentratedunder reduced pressure. The residue was dissolvedin 40 mL of anhydrous acetonitrile, 2.25 g (15 mmol) ofdry NaI was added, the mixture was refluxed for 1 h,cooled to 8C, the precipitate was separated by filtration,washed with boiling acetonitrile (10 mL) anddried in a vacuum. The precipitate was identified as a1 : 1 complex of L with NaI. Yield 4.3 g, 77%. ForC44H44INaO6P2 anal. calcd. (%): C, 60.01; H, 5.04; P,7.03. Found (%): C, 59.81, 59.73; H, 4.52, 4.90;P, 6.63, 6.91.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Bezhin; Dovhyi; Lyapunov, A. Yu.; Baulin; Baulin; Tsivadze, A. Yu.; Russian Journal of Inorganic Chemistry; vol. 64; 9; (2019); p. 1178 – 1185; Zh. Neorg. Khim.; vol. 64; 9; (2019); p. 997 – 1005,9;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

112-26-5, A common compound: 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

A mixture of 1,2-bis(2-chloroethoxy)ethane (5.00 g, 26.73 mmol, 1.00 Eq) and NaI (12.02 g, 80.19 mmol, 3.00 Eq) in acetone (50 mL) was stirred at 56 C. for 72 hr under N2 atmosphere. Most solid sodium chloride was formed. After filtration of the resulting sodium chloride, the solution was concentrated in vacuum. The residue was diluted with CH2Cl2 (200 mL) and the solution was washed with water (100 mL), dried over Na2SO4 and evaporated in vacuum. The residue was purified by chromatography on silica gel (eluting with PE_EA=100:1 to 10:1) to afford the pure product 1,2-bis(2-iodoethoxy)ethane (9.10 g, 24.60 mmol, 92.02% yield) as a colorless oil. 1H NMR (400 MHz, CDCl3) delta 3.80 (t, J=6.90 Hz, 4H), 3.70 (s, 4H), 3.29 (t, J=6.78 Hz, 4H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(2-chloroethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Novira Therapeutics, Inc.; Hartman, George D.; Kuduk, Scott; (85 pag.)US2016/272599; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics