Author: tianli

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 139512-70-2, name is 4-Chloro-5-fluorobenzene-1,2-diamine, A new synthetic method of this compound is introduced below., Product Details of 139512-70-2

General procedure: A mixture of compounds 1a-l (0.013 mol) and 4-chloro-5-fluoro-ophenylenediamine(2) (0.01 mol) in methanol (10 mL) was irradiatedwith ultrasonic irradiation at 50 C for 7 min (8 min for 3a) Afterreaction completion (monitored by TLC, ethyl acetate/hexane = 3:1), themixture was poured onto water and the precipitated product was filtrated off, washed with water and recrystallised from ethanol/water, 3:1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Mente?e, Emre; Kahveci, Bahittin; Mente?e, Meltem; Journal of Chemical Research; vol. 42; 6; (2018); p. 329 – 331;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 56961-77-4,Some common heterocyclic compound, 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, molecular formula is C6H3BrCl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a nitrogen atmosphere, a flask containing 60 N1,N1,N3-triphenylbenzene-1,3-diamine (51.7 g), 44 1-bromo-2,3-dichlorobenzene (35.0 g), Pd-132 (0.6 g), 45 NaOtBu (22.4 g), and 28 xylene (350 ml) was heated and stirred at 90 C. for two hours. The reaction liquid was cooled to room temperature. Thereafter, 30 water and 40 ethyl acetate were added thereto, and the resulting mixture was partitioned. Subsequently, purification was performed by silica gel column chromatography (eluent: toluene/heptane=5/5 (volume ratio)) to obtain 61 N1-(2,3-dichlorophenyl)-N1,N3,N3-triphenylbenzene-1,3-diamine (61.8 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2,3-dichlorobenzene, its application will become more common.

Reference:
Patent; JNC CORPORATION; FUJITA, Yukihiro; (228 pag.)US2019/165279; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1008361-80-5, name is 4-Bromo-3-chlorobenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Bromo-3-chlorobenzene-1,2-diamine

Compound S3 was prepared following the procedure from PCT Int. Appl. 2012068106: l,3-Bis(methoxycarbonyl)-2-methyl-2-thiopseudourea (0.321 g) was added to a slurry of 4-bromo-3-chlorobenzene-l,2-diamine (0.2 g), 1,2-dimethoxy ethane (2 mL) and MeOH (0.5 mL). The reaction mixture was heated at 105 C for 18 hours. The solvent was removed under reduced pressure, the residue was washed with ether, and filtered. The resulting solid was purified by ISCO (eluent: 0-2 % MeOH in CH2CI2) to afford the title compound as a white solid.

According to the analysis of related databases, 1008361-80-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (447 pag.)WO2017/35408; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 63624-28-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63624-28-2, name is 2,4-Dimethoxybenzene-1-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of hydrogen chloride gas in dry ethyl acetate (1.5 M,3.0 mL) was added intermediate IM 3 (0.3 g, 0.6 mmol). The reactionmixture was stirred for 4 h at room temperature. The solvent was removedunder reduced pressure to give solid deprotected product.Various substituted-phenyl sulfonyl chlorides were added dropwise in a mixture of deprotected product and triethylamine (0.5 mL) in anhydrousCH2Cl2 (10 mL). After stirring at room temperature overnight, thereaction mixture was concentrated using a rotary evaporator. The crudeproduct was purified by chromatography on silica gel utilized a mixtureof chloroform and acetone (35:1, v/v) as eluent to furnish the desiredproduct.

The chemical industry reduces the impact on the environment during synthesis 2,4-Dimethoxybenzene-1-sulfonyl chloride. I believe this compound will play a more active role in future production and life.

Reference:
Article; Yuan, Lei; Liu, Jun; He, Wenhui; Bao, Youmei; Sheng, Lei; Zou, Chunyang; Hu, Baichun; Ge, Wentao; Liu, Yang; Wang, Jian; Lin, Bin; Li, Yanchun; Ma, Enlong; Bioorganic Chemistry; vol. 84; (2019); p. 239 – 253;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 102-49-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 102-49-8 as follows.

5.1.2.5 (2r)-N1,N3-Bis(3,4-dichlorobenzyl)-2-nitrocyclohexane-1,3-diamine (7d) 3,4-Dichlorobenzylamine (221 mg, 1.3 mmol) was added to a solution of nitrodiol 6 (101 mg, 0.6 mmol) in H2O (5 mL) and the suspension was stirred overnight at rt. A few drops of CH3OH were added and the mixture was stirred at rt for another 24 h. The mixture was cooled to -6 ¡ãC for a few days. The resulting precipitate was collected by filtration and dried. Colorless solid, mp 92 ¡ãC, yield 258 mg (86percent). C20H21CI4N3O2 (477.2). Rf = 0.78 (CH3OH). 1H NMR (CDCl3): delta (ppm) = 1.08 (qd broad, 2J = 3J = 12.6 Hz, 3J = 3.6 Hz, 2H, 4-Ha, 6-Ha), 1.29 (qt, 2J = 3J = 13.2 Hz, 3J = 3.2 Hz, 1H, 5-Ha), 1.81 (dquint, 2J = 13.8 Hz, 3J = 3.3 Hz, 1H, 5-He), 2.16 (dq, 2J = 13.1 Hz, 3J = 3.4 Hz, 2H, 4-He, 6-He), 3.00 (td, 3J = 11.1 Hz, 3J = 4.1 Hz, 2H, 1-H, 3-H), 3.65 (d, 2J = 13.7 Hz, 2H, Ph-CH2), 3.81 (d, 2J = 13.7 Hz, 2H, Ph-CH2), 4.17 (t, 3J = 10.4 Hz, 1H, 2-H), 7.08-7.12 (m, 2H, Ph-H), 7.33-7.38 (m, 4H, Ph-H). Signals for the NH-protons are not visible in the 1H NMR spectrum. IR: (cm-1) = 3329 (m, nu (N-H)), 1557 (s, nu (NO2)), 1359 (m, nu (NO2)), 820 (m, out-of-plane (Ar-H)). MS (EI): m/z (percent) = 477 (M+, <1), 174 (C7H5Cl2NH+, 56), 159 (C7H5Cl2+, 100). According to the analysis of related databases, 102-49-8, the application of this compound in the production field has become more and more popular. Reference:
Article; Bourgeois, Christian; Werfel, Elena; Schepmann, Dirk; Wuensch, Bernhard; Bioorganic and Medicinal Chemistry; vol. 22; 13; (2014); p. 3316 – 3324;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 157590-59-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 157590-59-5, name is 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of Intermediate II (300 mg, 0.887 mmol) and triethylamine (500 mg, 5 mmol) in DMF (5 mL) was added HATU (370 mg, 0.97 mmol) at 0 C. After the mixture was stirred for 15 min, 4-chloro-5-(trifluoromethyl)benzene-1,2-diamine (228 mg, 1.09 mmol) in DMF (1 mL) was added to the reaction. The mixture was allowed to warm to room temperature and stirred for 20 hrs. The reaction was diluted with water (50 mL) and the white solid was precipitated. The mixture was filtered and the solid was dried enough under reduced pressure. The solid was dissolved in acetic acid (5 mL) and the mixture was stirred at 85 C. for 5 hrs. Solvent was removed. The residue was purified by silica gel chromatography (eluted with DCM: MeOH=50:120:1) to give the title compound (205 mg, 45%) as a light yellow solid.

The synthetic route of 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BeiGene Ltd.; Zhou, Changyou; Wang, Zhiwei; Zhang, Guoliang; (95 pag.)JP2016/196446; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 928782-97-2, name is 4-Chloro-2-(phenylethynyl)aniline, A new synthetic method of this compound is introduced below., name: 4-Chloro-2-(phenylethynyl)aniline

A mixture of 2-alkynylaniline 1a-1e (0.2 mmol), dichalcogenide 2a-2e (0.15 mmol), CuI (0.02 mmol), and Cs2CO3 (0.2 mmol) in DMSO (2 mL) was stirred at 80 C under an air atmosphere. After completion of the reaction that was monitored by GC-MS or TLC, 25 mL water was added, and the mixture was extracted with ethyl acetate, the combined organic layers were washed with water (10 mL x 3), dried over anhydrous Na2SO4. After filtration and removal of solvents in vacuum, the residue was purified by silica gel column chromatography to afford the corresponding products.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Li, Zhen; Hong, Longcheng; Liu, Ruiting; Shen, Jianzhong; Zhou, Xigeng; Tetrahedron Letters; vol. 52; 12; (2011); p. 1343 – 1347;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 874-17-9, name is 4-Chloro-2,6-dibromoaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 874-17-9, SDS of cas: 874-17-9

Pd(OAc)2 (0.01 g, 0.04 mmol), 2,6-dibromo-4-chlorobenzenamine (0.57 g, 2 mmol), K2CO3 (0.55 g, 4 mmol) and phenylboronic acid (0.54 g, 4.4 mmol) were placed in a 100 ml flask and allowed to stir at 25 C for 24 h, in the presence of 10 ml PEG-400. The mixture was extracted three times with 10 ml diethyl ether. The combined organic phase was dried over MgSO4, filtered, and the solvent was removed. The residue was purified by chromatography on silica gel with petroleum ether/ethyl ester (v/v = 20:1) to give 4-chloro-2,6-diphenylbenzenamine (0.34 g, 60% yield). 1H NMR (400 MHz, CDCl3): delta 3.71 (s, 2H, -NH2), 7.00 (s, 2H, benzenamine), 7.28 (t, 2H, phenyl ring), 7.33-7.40 (m, 8H, phenyl ring). 13C NMR (400 MHz, CDCl3): delta 124.82 (benzenamine carbon connected with Cl), 127.47 (benzenamine carbon connected with phenyl), 128.38 (benzenamine carbon near Cl), 128.98 (phenyl carbon), 129.58 (phenyl carbon near benzenamine), 130.46 (phenyl carbon), 138.46 (phenyl carbon connected with benzenamine), 139.74 (benzenamine carbon connected with NH2).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Yuan, Jianchao; Wang, Fuzhou; Yuan, Bingnian; Jia, Zong; Song, Fengying; Li, Jing; Journal of Molecular Catalysis A: Chemical; vol. 370; (2013); p. 132 – 139;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

139512-70-2, name is 4-Chloro-5-fluorobenzene-1,2-diamine, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 4-Chloro-5-fluorobenzene-1,2-diamine

General procedure: A mixture of compounds 1a-l (0.013 mol) and 4-chloro-5-fluoro-ophenylenediamine(2) (0.01 mol) in methanol (10 mL) was irradiatedwith ultrasonic irradiation at 50 C for 7 min (8 min for 3a) Afterreaction completion (monitored by TLC, ethyl acetate/hexane = 3:1), themixture was poured onto water and the precipitated product was filtrated off, washed with water and recrystallised from ethanol/water, 3:1.

The synthetic route of 139512-70-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mente?e, Emre; Kahveci, Bahittin; Mente?e, Meltem; Journal of Chemical Research; vol. 42; 6; (2018); p. 329 – 331;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 348-59-4, name is 2,5-Dichlorofluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 348-59-4, Quality Control of 2,5-Dichlorofluorobenzene

Reference Example 2-46 2,5-Dichloro-4-fluorobenzoic acid Following the procedure described in Reference Example 2-25, the title compound was prepared from 1,4-dichloro-2-fluorobenzene (68% yield). NMR (CDCl3) delta: 7.33 (1H, d, J=8.8 Hz), 7.45 (1H, br s), 8.15 (1H, d, J=7.6 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Uchikawa, Osamu; Mitsui, Keita; Asakawa, Akiko; Morimoto, Shigeru; Yamamoto, Masataka; Kimura, Hiroyuki; Moriya, Takeo; Mizuno, Masahiro; US2003/187014; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics