Author: Jessica.F

Elson, Leslie A.; Gibson, Charles S.; Johnson, John D. A. published an article in 1929, the title of the article was Monohalomononitrotoluenes. Arsenical compounds derived from 3-bromo-4-nitrotoluene.Computed Properties of 38939-88-7 And the article contains the following content:

The 2 remaining bromonitrotoluenes are described. Reduction of the 5-NO2 derivative with Fe and dilute AcOH gives 5-amino-2-acetamidotoluene, m. 143°; partial deamination of the 2,5-di-NH2 derivative was not very successful. 4,3-O2N(H2N)C6H3Me (I) was prepared by heating 3,4-(O2N)2C6H3Me with concentrated NH4OH at 150° for 6 h. Through the diazo reaction there resulted from 15 g. I 9.9g. of the 3-Cl derivative, b19 146°, m. 22°; 30 g. I gives 23 g. of the 3-Br derivative, yellow, b19 156-8°, m. 37°; the 3-I derivative, orange-yellow, m. 103-5°. 3,5-Br(AcNH)C6H3Me with HNO3 of d. 1.5 gives the di-NO2 derivative but is unchanged with HNO3 of d. 1.45 at 0° for 10 min. Treating a mixture of 4,2,3-H2N(O2N)2C6H2Me in HCl-EtOH with NaNO2 below 0° and gradually warming to 70° gives a moderate yield of 3-chloro-2-nitrotoluene, m. 21-2°; 3-Br derivative, pale yellow, b10 129-30°, m. 27°; the residue consists of a pale yellow compound, C12H9O4N2Br2, m. 95-6°. 4,2,6-H2N(O2N)2C6H2Me, through the diazo reaction, gives the 4-Br derivative, orange-yellow, m. 89-90°. 3,2-Br(O2N)C6H3Me did not yield a satisfactory condensation product with o-H2NC6H4AsO2H2 but 3,4-Br(O2N)-C6H3Me gives 2-nitro-5-methyldiphenylamine-6′-arsonic acid, golden yellow, m. 228 30°; reduction with SO2 in EtOH-HCl gives the 6′-dichloroarsine, orange-red, m. 137° (decomposition), which, heated with AcOH for 2 h., yields 10-chloro-4-nitro-1-methyl-5,10-dihydrophenarsazine, deep red, m. 198-200° (decomposition). The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Computed Properties of 38939-88-7

2-Chloro-4-methyl-1-nitrobenzene(cas:38939-88-7) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Computed Properties of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kohlrausch, K. W. F. published an article in 1947, the title of the article was Studies of Raman effect. CLXXIII. Benzene derivatives. 30. Interpolated Raman spectra.Computed Properties of 452-75-5 And the article contains the following content:

Since a stepwise substitution of X = NH2, OH, Me, Cl, Br, I produces a regular frequency transition from one derivative to another, the spectra of members of the series not yet determined or undeterminable for any reason can be determined by interpolation. This is done for m- and o-C6H4(NH2)2, NH2C6H4OH, NH2C6H4F, FC6H4OH, BrC6H4OH, FC6H4Br, IC6H4NH2, IC6H4OH, IC6H4F, IC6H4Br, C6H4I2 1,3,5-F3C6H3, 1,3,5-Me2FC6H3, 1,3,2-Me2FC6H3, 1,2 3-Me2FC6H3, 1,3,4-Me2FC6H3, 1,2,4-Me2FC6H3, 1,4,2-Me2FC6H3, 1,4,2-MeClFC6H3, 1,4,2-Cl2FC6H3, 1,3,4-Cl2FC6H3. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Computed Properties of 452-75-5

4-Chloro-2-fluorotoluene(cas:452-75-5) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Computed Properties of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kuhn, Richard; Trischmann, Heinrich published an article in 1958, the title of the article was Trimethylsulfoxonium ion.Synthetic Route of 5034-06-0 And the article contains the following content:

Me2SO (I) (16 g.) and 30 ml. MeI refluxed 3 days gave 25 g. octagonal plates of trimethylsulfoxonium iodide, Me3S+OI- (II), m. 200° (H2O), insoluble in C6H6, Et2O, CHCl3, petr. ether, sparingly soluble in MeOH, soluble in H2O (1.5 g. in 100 ml. at 20°). II shaken with an aqueous suspension of AgCl gave the H2O-soluble chloride, long needles, (MeOH-C6H6); picrate, decompose 210° (H2O); tetraphenylborate, m. 195° (aqueous EtOH). The reineckate, phosphomolybdate, and phosphotungstate are very little soluble Thermal decomposition of II gave I. II shaken with aqueous CO2-free Ag2O gave the oily hydroxide, which in the presence of air crystallized to the bicarbonate or carbonate. Reduction of II with HI gave blue-black crystals of the periodide, Me3S+I3-, which on boiling with H2O yielded iodine and Me3S+I-, identical with an authentic specimen. II (1 g.) and 5 ml. pyridine (III), refluxed 15 min., or the chloride and III refluxed 240 min. at 115°, gave quant. yields of III.MeI and III.MeCl, resp. Similarly II and quinoline gave the corresponding MeI derivative, m. 70-2° (monohydrate) (EtOH). II (2.2 g.), 0.7 g. p-O2NC6H4OH, and 10 g. Ag2O in Me2NCHO shaken 2 days at 20°, CHCl3 added, the mixture filtered, washed with 2N NaOH and H2O, dried, and concentrated gave 78% p-O2NC6H4OMe, m. 55°, b0.1 100-5°. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Synthetic Route of 5034-06-0

trimethyloxosulphonium chloride(cas:5034-06-0) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Synthetic Route of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Brown, J. P.; McCall, E. B. published an article in 1955, the title of the article was Some chlorinated hydroxyphenoxyacetic acids.Synthetic Route of 74672-01-8 And the article contains the following content:

Efforts to determine the fate of 2,4-Cl2C6H3OCH2CO2H in plants and in soil substrates led to the present syntheses of various chlorinated (hydroxyphenoxy)acetic acids. A metabolite isolated from cultures of bacteria grown in a medium containing 4-ClC6H4OCH2CO2H [Evans and Smith, Biochem. J. 57, Number 4, xxx(1954)] was believed to be 4,2-Cl(HO)C6H3OCH2CO2H (I), so its synthesis was first undertaken. 4-ClC6H4OCH2CO2H (10 g.) heated 2 h. at 90° with 100 mL. concentrated HNO3 gave 7.0 g. 4,2-Cl(O2N) C6H3OCH2CO2H (II), m. 173-5° (from aqueous MeOH); II (1.0 g.) reduced with Na Na2S2O4 at 90° and acidified to pH 4 gave 0.15 g. white needles, m. 215-18°, and the filtrate boiled with 32% HCl yielded 0.52 g. of the same material. This was the lactam of 4,2-Cl(H2N)C6H3OCH2CO2H, 6-chloro-3,4-dihydro-3-oxobenzoxazine, m. 217-18° (from EtOH). II (5.0 g.)was also boiled in 50 mL. C6H6, with 8.0 mL. SOCl2, 8 h., the C6H6 and excess SOCl2 evaporated, 4.0 g. 20% solution of NHMe2 in C6H6 added to the residue, and the mixture allowed to stand overnight, then concentrated, and filtered, giving 4.7 g. crude 4,2-Cl(O2N)C6H3OCH2CONMe2, m. 84° (100-1° on recrystallization from MeOH), reduced by Fe and HOAc in aqueous EtOH to the 2-H2N analog, m. 121° (from EtOH). Attempts to replace the NH2 group by OH in both the NH2 acid and its dimethylamide failed. 5,2-Cl(HO)C6H3Ac (2.8 g.) boiled 4 h. with 3.2 g. NaOH and 4.7 g. ClCH2CO2H in 30 mL. H2O, cooled, and acidified gave 2.4 g. 4,2-ClAcC6H3COCH2CO2H, m. 177-8° (from aqueous MeOH). Efforts to oxidize this to I were unsuccessful. 4,1,2-ClC6H3(OH)2 (14.8 g.) added to a solution of 2.8 g. Na in 60 mL. dry EtOH and the boiling mixture treated with 3.7 g. ClCH2CO2Et, gave 6.4 g. impure 5,2-Cl(HO)C6H3OCH2CO2H, m. 157° (from H2O), forming with Me2SO4 and hot 20% aqueous NaOH with a Me ether (III), m. 143-5° (from aqueous MeOH). The identity of III was established by first reducing 4-nitroguaiacol with H at room temperature and atm. pressure over Pd-C to the amino compound, converting it to the HCl salt, diazotizing, and adding CuCl to give 4-chloroguaiacol, m. 36-7°, which, allowed to react with ClCH2CO2H in NaOH and H2O 2 h. at 95°, then acidified, gave 5,2-Cl(MeO)C6H3OCH2CO2H, m. 141-3° (from C6H6), identical with III. 4-Nitroguaiacol and ClCH2CO2H condensed in the presence of NaOH to either 2,5-HO(O2N)C6H3OCH2CO2H (IV), m. 191° (from aqueous MeOH), or the 2-MeO analog (V), m. 180-2° (from aqueous MeOH), depending on the concentration of NaOH used. IV reduced, diazotized, and treated with CuCl as above gave 5,2-Cl(HO)C6H3OCH2CO2H, m. 157° (from H2O and aqueous MeOH), and V gave first 5,2-H2N(MeO) C6H3OCH2CO2H, m. 232° (from H2O), and finally 5,2-Cl(MeO)C6H3OCH2CO2H, m. 140-2° (from aqueous MeOH). 5-Nitroguaiacol converted to 5-chloroguaiacol, m. 16-17°, as described above for the 4-Cl compound, then treated with ClCH2CO2H, yielded 4,2-Cl(MeO)C6H3OCH2CO2H, m. 135-6° (from C6H6 or aqueous MeOH), which (0.2 g.), boiled 1 h. with 2.0 mL. 48% aqueous HBr, gave on cooling 0.15 g. I; after recrystallization from H20, slowly I, m. 110° on slow, 124-30° on rapid heating. 5-Nitroguaiacol (2.0 g.) with 1.5 g. ClCH2CO2Et in the presence of NaOMe gave 0.5 g. 2,4-MeO(O2N)C6H3OCH2CO2Et, m. 88-91° (from MeOH). 3,5,1,2-Cl2C6H2,(OH)2 and ClCH2CO2Et gave 2,4,6-Cl2(HO)C6H2OCH2CO2H (VI), m. (depending on the rate of heating) 130-55° (after recrystallization from H2O), identical with the substance prepared by Cavill and Ford (C.A. 49, 3072h). Its Me ether, m. 174-6°. 2,4-Cl2C6H3OH nitrated with concentrated HNO3 at 30-40° to 2,4,6-Cl2(O2N)C6H2OH, m. 122-4°, then reduced in alk. Na2S2O4, neutralized with HOAc, and the resulting aminophenol acetylated with Ac2O yielded 4,6,2-Cl2(AcNH)C6H2OH, m. 138-40° (from aqueous EtOH), which, boiled 6 h. in acetone with MeI and K2CO3, formed 4,6,2-Cl2(AcNH)C6H2OMe, m. 112-14° (from light petroleum, b. 60-80°), hydrolyzed by boiling 1 h. in 20% HCl to 4,6,2-Cl2(H2N)C6H2OMe.HCl, m. 196° (from dilute HCl), converted with NaOH to the amine, f.p. 16°. The amine diazotized and the diazonium solution added to CuSO4 in H2O with simultaneous passage of steam yielded from the steam distillate 4,6-dichloroguaiacol, m. 63-4° (from light petroleum, b. 60-80°), converted in the usual way into 3,5,2-Cl2(MeO)C6H2OCH2CO2H, m. 106-7° (from PhMe). The MeO acid, boiled 1 h. with 48% HBr gave 3,5,2-Cl2(HO)C6H2OCH2CO2H, m. 154° (from H2O). 2,4-Cl2C6H3NH2 (12 g.) in 450 mL. acetone and 700 mL. H2O containing 11 g. KOH treated during 5 h. at 25° with 20 g. K2S2O8 in 450 mL. H2O gave only 1.5 g. product which, boiled with 20% HCl, basified with NaHCO3, and Ac2O added yielded 0.4 g. 3,5,2-Cl2(AcNH)C6H2OH, m. 190-3° (from aqueous MeOH), methylated with MeI to 3,5,2-Cl2(AcNMe)C6H2OMe (VII), m. 107-9° (from light petroleum, b. 60-80°). This route to 3,5-dichloroguaiacol was abandoned, though, because of the poor yields in these 2 steps. When 9.0 g. 5-chlorovanillic acid in 90 mL. glycerol containing 0.2 g. Cu bronze was heated 10 min. at 250-60°, and steam was passed through the mixture, 1.7 g. 3-chloroguaiacol, m. 54° (from light petroleum, b. 60-80°) was recovered from the distillate; a C6H6 solution of this compound did not react with SO2Cl2 at room temperature, and boiling with a large excess of SO2Cl2 gave a mixture from which 5% of a trichloroguaiacol, m. 102-4° (from light petroleum, b. 60-80°) was isolated. 5-Chlorovanillic acid (5.0 g.) was dissolved in 30 mL., warm concentrated H2SO4, 50 mL. CHCl3 added, and the mixture stirred at 45° while 2.5 g. NaN3 was added during 30 min., then poured onto ice, and filtered. If the filtrate was basified at this point, it gave a rapidly discoloring precipitate of 5-amino-3-chloroguaiacol which could be converted by the addition of Ac2O into 5-acetamido-3-chloroguaiacol, m. 165° (from H2O). To obtain 3,5-dichloroguaiacol, the filtrate was treated with BaCl2 solution to remove the sulfate, and the remaining amine hydrochloride solution diazotized and treated with urea and a solution of CuCl2; steam distillation, extraction with Et2O, and vacuum-distillation gave 0.3 g. material, b15 170° (bath temperature), which, recrystallized 3 times from light petroleum (b. 60-80°), gave 3,5-dichloroguaiacol (VIII), m. 64-5°, also obtained from 2,4,6-Cl3C6H2NO2 by condensation with NaOMe to 3,5,6-Cl2(O2N)C6H2OMe, m. 70-2° (from EtOH) and reduction with H (Raney Ni) to 3,5,2-Cl2(H2N)C6H2OMe (IX). Acetylation of IX gave the N-Ac derivative, m. 169.5-71.5° (from PhMe), and methylation gave VII. IX in concentrated H2SO4 converted into VIII as described in the diazotization of the 4,6-Cl2 isomer. VIII (0.6 g.) yielded in the usual way 0.7 g. VI, identical with the acid from 3,5,1,2-Cl2C6H2(OH)2. 2-ClC6H3OCH2CO2H boiled with concentrated HNO3 5 min. gave the 4-O2N derivative, m. 179-81° (from aqueous EtOH), esterified with MeOH and. concentrated H2SO4 to the Me ester, m. 124°. Hydrogenation of the ester in MeOH over Pd gave 2,4-Cl(H2N)C6H3OCH2CO2Me, m. 69° (from petr. ether, b. 60-80°), which was diazotized, added to CuSO4 in boiling H2O, the product extracted with Et2O, dissolved in NaOH, precipitated with acid, dried, treated with boiling C6H6, and the fraction insoluble in C6H6 recrystallized twice from H2O to give 2,4-Cl(HO)C6H3O CH2 CO2H acid (X), m. 146-7° [Me ether, m. 136-8° (from PhMe)]. Another synthesis of X involved chlorinating p-MeOC6H4OH with SO2Cl2 to 2,4-Cl(MeO)C6H3OH, b15 108°, m. 46-7° (from petr. ether, b. 60-80°), and converting this in the usual way to a phenoxyacetic acid, which was identical with the above 2,4-Cl(MeO)C6H3OCH2CO2H and on boiling with 48% HBr gave X. A bacterial metabolite of 2,4-Cl2C6H3OCH2CO2H has been isolated by Evans which is not identical with any of the hydroxyphenoxyacetic acids described above. The experimental process involved the reaction of 1,5-Dichloro-3-methoxy-2-nitrobenzene(cas: 74672-01-8).Synthetic Route of 74672-01-8

1,5-Dichloro-3-methoxy-2-nitrobenzene(cas:74672-01-8) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Synthetic Route of 74672-01-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Brieux, Jorge A.; Deulofeu, Venancio published an article in 1954, the title of the article was The reaction velocity of some substituted o- and p-chloro-nitrobenzenes with piperidine.Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:

cf. C.A. 46, 2382i. The velocity constants for the reaction of some R-monosubstituted (R = Me, OMe, and OEt) o-and p-chloronitrobenzenes with piperidine (I) in C6H6 at 100° have been determined Possible reasons for the order of reactivity are given. Rates were measured at 100° by halide determination The rate constants were calculated for the over-all reaction O2NC6H3RCl + 2C5H10NH → O2NC6H3RNC5H10 + C5H10-NH.ClH. The mean deviation of the mean for the reaction of the rates was 2-3%. Average mean values of at least 2 independent runs expressed as 107k (1. mole-1sec.-1, are as follows for ClRC6H3NO2, where R = H, Me, MeO, and EtO, resp.: 4-ClC6H4NO2, 16.8, -, -, -; 4,3-ClRC6H3NO2, -, 0, 7.0, 4.16; 4,2-ClRC6H3NO2, -, 3.6, 14.1, 4.45; 2-ClC6H4NO2, 779, -, -, -; 2,3-ClRC6H3NO2, -, 5.55, 152, 123; 2,4-ClRC6H3NO2, -, 772, 2630, 1820; 2,5-Cl RC6H3NO2, -, 152, 35.9, 30.2; 2,6-ClRC6H3NO2, -, 12.1, 23.3, 9.73. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene

2-Chloro-4-methyl-1-nitrobenzene(cas:38939-88-7) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Brieux, J. A.; Deulofeu, V. published an article in 1956, the title of the article was Reaction velocity of 2- and 4-chloronitrotoluenes, -anisoles and -phenetoles with piperidine in benzene.Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:

cf. C.A. 46, 11126a. The velocity constant for the reaction of piperidine with the title compounds was determined at 100° by titrating potentiometrically the liberated Cl-. The equation k = t(b – 2a) ln [a(b – 2x)/b(a – x)] (a and b = initial concentrations of chloro compounds and piperidine, x = concentration of Cl- at time t) was used. Thus were determined the following (compound, k × 107 mole-1 sec.-1): 4-ClC6H4NO2, 16.8; 3,4-MeClC6H3NO2, 0;4,3-Cl(MeO)C6H3NO2, 7.0; 4,3-Cl(EtO)C6H3NO2, 4.16; 2,4-MeClC6H3NO2, 3.6; 4,2-Cl(MeO)ClC6H3NO2, 14.1; 4,2-Cl(EtO)C6H3NO2, 4.45; 2-ClC6H4NO2, 779; 2,3-ClMeC6H3-NO2, 5.55; 2,3-Cl(MeO)C6H3NO2, 152; 2,3-Cl(EtO)C6H3-NO2, 123; 2,4-ClMeC6H3NO2, 772; 2,4-Cl(MeO)C6H3NO2, 2630; 2,4-Cl(EtO)C6H3NO2, 1820; 2,5-ClMeC6H3NO2, 152; 2,5-Cl(MeO)C6H3NO2, 35.9; 2,5-Cl(EtO)C6H3NO2, 30.2, 2,6-ClMeC6H3NO2, 12.1; 2,6-Cl(MeO)C6H3NO2, 23.3; 2,6-Cl(EtO)C6H3NO2, 9.73. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene

2-Chloro-4-methyl-1-nitrobenzene(cas:38939-88-7) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chardonnens, Louis; Wurmli, Albert published an article in 1946, the title of the article was Derivatives of fluorenone. II. 3,6-Dimethylfluorenone.Application In Synthesis of 5,5′-Dimethyl-[1,1′-biphenyl]-2,2′-dicarboxylic acid And the article contains the following content:

cf. C.A. 40, 1479.2. Diazotization of 4,2-Me(H2N)C6H3CO2H (I) and treatment of the solution with NH3-Cu2O gives 84% 5,5′-dimethyl-2,2′-dicarboxybiphenyl, m. 269° (all m.ps. corrected). When this is mixed with CaO and heated 2 hrs. at 350° it gives 23% 3,6-dimethylfluorenone (II), m. 118° (oxime m. 189-91°), but the product is always contaminated with a red oil which can be separated only by chromatography. It is therefore better to treat I with NaOH and MeC6H4SO2Cl to get 77% 4-methyl-2-tosylaminobenzoic acid, m. 208-9°. With PCl5 this gives the acid chloride which reacts with MePh and AlCl3. The product is saponified to give 65% 4,4′-dimethyl-2-aminobenzophenone (III), m. 119°. 4,4′-Dimethyldiphenyl sulfone is a by-product. Diazotization of III in H2SO4 gives 70% II and a little 4,4′-dimethyl-2-hydroxybenzophenone, m. 73-4°. When II is heated 6 hrs. at 175° in a sealed tube with N2H4.H2O and Na in EtOH, it gives 85% 3,6-dimethylfluorene, m. 130-1°. Direct nitration of II with H2SO4 and KNO3 gives only 3,6-dimethyl-2,7-dinitrofluorenone (IV), m. 281° (decomposition). The mononitro compound cannot be prepared in this way. 4-Methyl-5-nitro-2-chlorobenzoic acid is converted to the acid chloride which, with MePh and AlCl3, gives 69% 4,4′-dimethyl-5-nitro-2-chlorobenzophenone, m. 108.5°. This heated 8 hrs. in a sealed tube at 160-70° with alc. NH3 gives 82% 4,4′-dimethyl-2-amino-5-nitrobenzophenone, m. 162.5°. This is diazotized in H2SO4 to give 59% 3,6-dimethyl-2-nitrofluorenone (V), m. 222-4°, and some 4,4′-dimethyl-5-nitro-2-hydroxybenzophenone, m. 144°. Nitration of V gives IV. The experimental process involved the reaction of 5,5′-Dimethyl-[1,1′-biphenyl]-2,2′-dicarboxylic acid(cas: 93012-36-3).Application In Synthesis of 5,5′-Dimethyl-[1,1′-biphenyl]-2,2′-dicarboxylic acid

5,5′-Dimethyl-[1,1′-biphenyl]-2,2′-dicarboxylic acid(cas:93012-36-3) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Application In Synthesis of 5,5′-Dimethyl-[1,1′-biphenyl]-2,2′-dicarboxylic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 17, 1954, there was a patent about dyes.Computed Properties of 452-75-5 The title of the patent was Anthraquinone vat dyes. And the patent contained the following:

A series of anthraquinone vat dyes of the general formula I, where R is p-ClC6H4CONH, or 2,4-F(Cl)C6H3CONH, or 2,5-F(Cl)C6H3CONH and A represents a dicarboxylic acid residue, was prepared Thus, 1-amino-5-(4-chloro-2-fluorobenzamido)anthraquinone (II) 5.9 and p-ClC6H4COCl 4 parts heated 0.5 hr. with stirring in C6H3Cl3 150 at 200-5°, the mixture cooled and filtered, and the residue washed with EtOH and dried gave a dye which could be purified further with hypochlorite solution, red in concentrated H2SO4, dyed cotton from a Bordeaux-colored Na2S2O4 vat fast pure-yellow tints. The 5-Cl isomer of II gave similarly a dye yielding somewhat more reddish yellow dyeings. II, m. 279°, was prepared by the acylation of 1,5-diaminoanthraquinone with 2,4-F(Cl)C6H3COCl (III) or from 1-chloro-5-(4-chloro-2-fluorobenzamido)anthraquinone by replacing the 1-Cl atom by a p-MeC6H4SO2NH residue followed by cleavage. The 5-Cl isomer of II, m. 269°, was prepared in the same manner. 2,4-F(Cl)C6H3Me, b743 158°, obtained from 2,4-NH2(Cl)C6H3NH2 through the diazonium fluoborate, gave by KMnO4 oxidation 2,4-F(Cl)C6H3CO2H (IV), m. 205°. IV treated with SOCl2 yielded III, b14 105-6°. 2,5-H2N(Cl)C6H3Me was converted through the diazonium fluoborate to 2,5-F(Cl)C6H3Me, b741 156°, and further to 2,5-F(Cl)C6H3CO2H, m. 149-50°, which yielded 2,5-F(Cl)C6H3COCl, b15 103-4°. II 7.9, (COCl)2 1.27, and C6H3Cl3 150 parts heated with stirring during 2 hrs. to 150°, the mixture heated further to 190°, kept 1 hr. at 190-200°, cooled to 100°, and filtered, and the residue washed with EtOH and dried (it may be purified by boiling the neutral aqueous suspension with hypochlorite) gave I, where A = O:CC:O and R = 2,4-F(Cl)C6H3CONH, Bordeaux in concentrated H2SO4, which dyed cotton fast greenish yellow tints from a Bordeaux vat. II 4,p-C6H4(COCl)2 1, and C6H3Cl3 150 parts refluxed 2 hrs. with stirring gave I, where A = p-O:CC6H4C:O and R = 2,4-F(Cl)C6H3CONH, which dyed cotton fast pure yellow tints. Thianthrene dicarboxylic acid 1.12, SOCl2 6, pyridine 0.05, and C6H3Cl3 90 stirred 0.5 hr. at 80° and then 0.5 hr. at 120°, the excess SOCl2 and some of the solvent distilled off. the residual solution cooled to 100° and treated with II 3 parts, and the mixture heated 2 hrs. at 200-10°, cooled to 120°, and filtered gave I, where R = 2,4-F(Cl)C6H3CONH and A = thianthrenedicarbonyl, red in concentrated H2SO4, dyed cotton fast yellow tints. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Computed Properties of 452-75-5

4-Chloro-2-fluorotoluene(cas:452-75-5) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Computed Properties of 452-75-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cooperstein, S. J.; Lazarow, A.; Patterson, J. W. published an article in 1953, the title of the article was The mechanism of Janus Green B staining of mitochondria. II. Reactions and properties of Janus Green B and its derivatives.Application of 4569-86-2 And the article contains the following content:

The absorption spectra are reported of Janus Green B(I) and G(II) and their derivatives, diethylsafranine, leucosafranine, and dimethylsafranine. I was readily reduced by cysteine (III) and glutathione whereas II was not significantly reduced by III. At pH 7.48 I showed 2 reduction steps upon polarographic analysis, one at a potential of -0.001 v. and the other at -0.188 v. II had only one reduction step at -0.214 v. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Application of 4569-86-2

3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas:4569-86-2) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Application of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hideo, Endo; Tada, Masao; Katagiri, Ken published an article in 1965, the title of the article was Antitumor activity of phenazine derivatives against S 180 and C 63 in mice I.SDS of cas: 4569-86-2 And the article contains the following content:

Phenazine and 68 derivatives of phenazine were screened for their antitumor activity against Sarcoma 180 and Carcinoma 63, transplanted in mice. The ratio of the average weights of tumors in the treated and the controls, and the ratio of body weight changes in the 2 groups were recorded for each compound 2-Methoxyphenazine, 3,7-diamino-2-methylphenazine and 3-morpholino-1,2-benzophenazine at doses of 50 mg./kg.-body weight/day, brought down the tumor weight to less than half in the carcinoma infected mice and 3-acetamido-7-amino-5-phenylphenazonium chloride at the same dosage caused a similar effect in the sarcoma-infected animals. No correlation was observed between tumor weight change and the change in body weight in the treated animals. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).SDS of cas: 4569-86-2

3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas:4569-86-2) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. SDS of cas: 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics