Author: Jessica.F

Engineering of the chloroaniline-catabolic plasmid pDCA-1 and its potential for genetic bioaugmentation was written by Ke, Zhuang;Wang, Shen;Dai, Weixian;Jia, Weibin;Mu, Yang;Jiang, Jiandong;Chen, Kai. And the article was included in International Biodeterioration & Biodegradation in 2022.Formula: C13H9Cl3N2O This article mentions the following:

Plasmids disseminate pollutant-catabolic genes through horizontal transfer and contribute to the catabolic potential of the host microbial community. Genetic bioaugmentation of conjugative catabolic plasmids has recently been considered an effective and novel approach for long-term bioremediation of contaminated sites. In this study, we engineered an IncP-1β-2 subgroup plasmid pDCA-1 from Achromobacter sp. ANB-1 for its potential application in genetic bioaugmentation. A dcaA1A2B cluster responsible for the deamination of chloroaniline to chlorocatechol and a 1,2-dioxygenase gene (ccdC) for the ring cleavage of chlorocatechol were found to locate on the broad host range plasmid pDCA-1. Insertion of an amidase gene (phh or tccA2) at the accessory region of plasmid pDCA-1 greatly expanded its catabolic substrate spectrum from chloroaniline (3-chloroaniline and 3,4-dichloroaniline) to herbicides (linuron, propanil, propham, and chlorpropham), bacteriostatic agent (triclocarban), plant regulator (forchlorfenuron), and insecticide (diflubenzuron). Taking advantages of high-throughput cell sorting and 16S rRNA gene-based amplicon sequencing, we depicted the diversity of bacterial recipients for the engineered plasmid pDCA-1-gfp-phh in a soil bacterial consortium, showing an excellent conjugative transfer capacity of the pDCA-1 derivative to various Gram neg. and even pos. strains in natural environment. All in all, the engineered plasmid pDCA-1 had a great potential in genetic bioaugmentation of the sites contaminated with chloroanilines and their derivatives In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Formula: C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Formula: C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The influence of heterostructured TiO₂/ZnO nanomaterials for the removal of azo dye pollutant was written by Gnanasekaran, Lalitha;Priya, A. K.;Ghfar, Ayman A.;Sekar, Karthikeyan;Santhamoorthy, Madhappan;Arthi, M.;Soto-Moscoso, Matias. And the article was included in Chemosphere in 2022.Recommanded Product: 61-73-4 This article mentions the following:

In recent times, there has been an inspired research on combining semiconducting metal oxides for improved industrial applications. Significantly, wastewater removal is concerned and the researchers are finding new methodologies for removing azo dyes that possess a high level of carcinogenic effects. In this connection, this work investigates the photocatalytic activity of synthesized TiO₂/ZnO nanocomposite irradiated under UV and visible light. The application of the work involves the removal of methylene blue (MB) dye solution Initial work begins with the novel synthesis of TiO₂/ZnO coupled system by integrated sol-gel and thermal decomposition methods. Then, various characterization techniques brought out the existing properties of the prepared TiO₂/ZnO catalyst. The X-ray diffraction measurements showed the assorted tetragonal and hexagonal structures. The spherical shape mixed with hexagonal shaped particles were perceived via transmission electron microscopy (TEM). Besides, from photoluminescence spectrum (PL) results, the TiO₂/ZnO coupled system displayed slowing down of charge recombination, because of the intermediate states that helps in intensifying the photocatalytic activity. The dual absorption bands corresponding to UV region were deep-rooted from UV-vis spectroscopy. Further, the valuable application of the catalyst in removing methylene blue (MB) dye under both UV and visible light was carried out. The catalyst had displayed 90% of degradation within 40 min under UV light conditions. The other hand, visible light illumination of the catalyst provides divergent results as it possess lesser light absorption. Therefore, this catalyst was unable to yield visible light photocatalytic activity. Hence, this captivating research would bring the wastewater treatment progression using UV light. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Recommanded Product: 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of safe one-pot synthesis of N-1- and C-2-substituted benzimidazole via reductive cyclization of o-nitroarylamine using Na₂S₂O₄ was written by Oda, Shinichi;Shimizu, Hideki;Aoyama, Yasunori;Ueki, Tatsuo;Shimizu, Sumio;Osato, Hiroshi;Takeuchi, Yoshiyuki. And the article was included in Organic Process Research & Development in 2012.Computed Properties of C9H8ClNO4 This article mentions the following:

We report that the reductive cyclization of o-nitroarylamine with aldehyde using sodium dithionite (Na₂S₂O₄) could be accelerated by addition of H₂O, which made it possible to control the heat release of the reaction by semibatch-type operation. Safety evaluation was performed using DSC, ARSST, in situ IR anal., and Multimax. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Computed Properties of C9H8ClNO4).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C9H8ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Highly enhanced biodegradation of pharmaceutical and personal care products in a novel tidal flow constructed wetland with baffle and plants was written by Cheng, Yu-Xiao;Chen, Jun;Wu, Dan;Liu, You-Sheng;Yang, Yong-Qiang;He, Lu-Xi;Ye, Pu;Zhao, Jian-Liang;Liu, Shuang-Shuang;Yang, Bin;Ying, Guang-Guo. And the article was included in Water Research in 2021.Reference of 101-20-2 This article mentions the following:

Research on decentralized wastewaters deserves special focus due to the potential abundance of emerging organic pollutants including pharmaceutical and personal care products (PPCPs), which might pose serious threats to the local water bodies and even to human health. Constructed wetland (CW) is a common decentralized wastewater treatment technol., with a certain ability to eliminate PPCPs. Nonetheless, PPCPs removal in common CWs is frequently challenging, besides, the removal mechanism remains elusive. Based on our previous study, tidal flow constructed wetlands (TFCWs) is effective in nitrogen removal. Here, 3 TFCWs with different modifications (baffle, plants, both baffle and plants) were constructed to treat raw domestic sewage and specifically to evaluate the removal efficiencies and mechanism of PPCPs. 24 PPCPs including 7 antibiotics, 8 steroid hormones and 9 biocides were detected in the level of 1.10 ± 0.29 ng/L-799 ± 10.6 ng/L in the influents. Consequently, we found that modification with both baffle and plants significantly influenced the removal of PPCPs. Moreover, the highest removal rates of biocides (97.1 ± 0.29%), steroid hormones (99.8 ± 0.02%), and antibiotics (90.2 ± 1.60%) were achieved via both baffles and plants in TFCWs. Based on the mass balance anal., microbial degradation dominated the removal of PPCPs with a percentage higher than 85.7%, followed by substrate adsorption (5.22 x 10^-2-14.3%) and plant uptake (1.66 x 10^-3-0.44%). Further, 16S rDNA sequencing anal. revealed that the presence of baffle and plants improve the removal efficiency of PPCPs by means of enhancing microbial diversity and changing dominant microorganisms. Moreover, Thaumarchaeota was potentially the key microorganism in the phylum level for PPCPs elimination by TFCWs through LEfSe (linear discriminant anal. (LDA) effect size) anal. These findings provide new insights into the removal of PPCPs in CWs. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Reference of 101-20-2).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 101-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antitumor activity of (4-hydroxyphenyl)[5-substituted alkyl/aryl)-2-thioxo-1,3,4-thiadiazol-3-yl]methanone and [(3,4-disubstituted)-1,3-thiazol-2-ylidene]-4-hydroxybenzohydrazide was written by Bhole, Ritesh P.;Bhusari, Kishore P.. And the article was included in Medicinal Chemistry Research in 2011.Reference of 6590-96-1 This article mentions the following:

To examine new drug leads with potential anticancer activity, some (4-hydroxyphenyl)[5-substituted alkyl/aryl-2-thioxo-1,3,4-thiadiazol-3-yl]methanones e.g., I and [-(3,4-disubstituted)-1,3-thiazol-2-ylidene]-4-hydroxybenzohydrazides e.g., II were synthesized using appropriate synthetic route. The newly prepared compounds, e.g., I and II demonstrated inhibitory effects on the growth of a wide range of cancer cell lines especially on leukemia (HL-60), non-small lung cancer (HOP-92), renal cancer (ACHN) at the range of GI₅₀ -4.23 to -7.23. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Reference of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Strengths of Acids in Acetonitrile was written by Kuett, Agnes;Tshepelevitsh, Sofja;Saame, Jaan;Lokov, Maert;Kaljurand, Ivari;Selberg, Sigrid;Leito, Ivo. And the article was included in European Journal of Organic Chemistry in 2021.Related Products of 101-20-2 This article mentions the following:

The equilibrium acidity scale (pK_a scale) in acetonitrile has been supplemented by numerous new compounds and new ΔpK_a measurements. It now contains altogether 231 acids – over twice more than published previously – linked by 569 ΔpK_a measurements and spans between the pK_a values of hydrogen iodide (2.8) and indole (32.57), covering close to 30 orders of magnitude. Measurement results acquired over the last 15 years were added to the scale and new least-squares treatment was carried out. The treatment yielded revised pK_a values for the compounds published previously, with the root mean square difference between revised and previous values 0.04, demonstrating very good stability of the scale. Correlation equations were developed for estimating pK_a values for the studied types of compounds in water, DMSO, DMF, and 1,2-dichloroethane on the basis of pK_a values in acetonitrile. These equations enable predicting pK_a values with an average error around or less than 1 pK_a unit, which is a sufficient accuracy for many applications. The scale is expected to be a useful tool for the widest possible research areas in organic chem., electrochem. power sources, catalysis, etc. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Related Products of 101-20-2).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 101-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Convenient Access to C10- and C11-(di)arylated dibenzo[b,f]azepines via Palladium-catalyzed C-H Bonds Cleavages was written by Li, Haoran;Roisnel, Thierry;Soule, Jean-Francois;Doucet, Henri. And the article was included in Advanced Synthesis & Catalysis in 2019.Related Products of 777-44-6 This article mentions the following:

Conditions allowing the C10- and C11-arylations of dibenzo[b,f]azepines via successive palladium-catalyzed reactions are reported. Using aryl bromides as the aryl source, the C10-arylation of dibenzo[b,f]azepines is very selective. Then, using benzenesulfonyl chlorides as the aryl source, the second arylation at C11-position is achieved affording non-sym. C10,C11-diarylated dibenzo[b,f]azepines I (R = n-Pr, i-Pr, Bn, Ph; Ar¹ = Ph, 4-MeC₆H₄, 3-OMeC₆H₄, 2-MeC₆H₄, 3-Py, 2-Naph, etc; Ar² = Ph, 4-tBuC₆H₄, 3-CF₃C₆H₄, 2-MeC₆H₄, etc). Both reactions tolerate a variety of substituents on the aryl source. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Related Products of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of the thieno[2,3-d]pyrimidine-2,4-dione derivative: A potent and orally bioavailable gonadotropin-releasing hormone receptor antagonist was written by Zou, Fangxia;Wang, Yao;Yu, Dawei;Liu, Chunjiao;Lu, Jing;Zhao, Min;Ma, Mingxu;Wang, Wenyan;Jiang, Wanglin;Gao, Yonglin;Zhang, Rui;Zhang, Jianzhao;Ye, Liang;Tian, Jingwei. And the article was included in European Journal of Medicinal Chemistry in 2022.Recommanded Product: 697-73-4 This article mentions the following:

Here, rationally designed and synthesized a series of derivatives (I [R¹ = 2-(2,6-difluorophenyl)ethyl, 2-[2-fluoro-6-(trifluoromethyl)phenyl]ethyl, 2-(3,5-difluoropyridin-4-yl)ethyl; R² = (2-fluoro-3-methoxyphenyl)methyl, [4-(2,2,2-trifluoroethoxy)phenyl]methyl, [3-(difluoromethoxy)-2-fluorophenyl]methyl, etc] and II [R³ = methoxymethyl, cyclobutoxymethyl, (cyclopropylmethoxy)methyl; R⁴ = 2-(dimethylamino)ethyl, 2-{methyl[2-(trifluoromethoxy)ethyl]amino}ethyl, 2-[(3S)-3-methoxypyrrolidin-1-yl]ethyl, etc]) through the modification and structure-activity relationship study of relugolix, which led to the discovery of II [R³ = methoxymethyl, R⁴ = 2-{methyl[2-(trifluoromethoxy)ethyl]amino}ethyl] as a highly potent GnRH-R antagonist (IC₅₀ = 2.18 nM) with improved membrane permeability (Papp, A-B = 0.98 x 10^-6 cm/s) and oral bioavailability (F % = 44.7). CompoundII [R³ = methoxymethyl, R⁴ = 2-{methyl[2-(trifluoromethoxy)ethyl]amino}ethyl] showed high binding affinity (IC₅₀ = 0.57 nM) and potent in vitro antagonistic activity (IC₅₀ = 2.18 nM) at GnRH-R. II [R³ = methoxymethyl, R⁴ = 2-{methyl[2-(trifluoromethoxy)ethyl]amino}ethyl] was well tolerated and efficacious in preclin. studies to suppress blood testosterone levels, which merits further investigation as a candidate novel GnRH-R antagonist for clin. studies. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antimicrobial activity of new urea and thiourea derivatives of (2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methanamine was written by Vedavathi, Pandreti;Sudhamani, Hasti;Raju, Chamarthi Naga. And the article was included in Research on Chemical Intermediates in 2017.Recommanded Product: 6590-96-1 This article mentions the following:

Synthesis of a series of novel urea and thiourea derivatives of (2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methanamine (valsartan intermediate) was accomplished by its reaction with various substituted aryl isocyanates and aryl isothiocyanates in presence of N,N-dimethylpiperazine (DMP). All synthesized compounds were evaluated for their antibacterial and antifungal activities and their min. inhibitory concentration (MIC) values determined A few of the title compounds showed good in-vitro antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. The title compounds also exhibited high antifungal activity. The title compounds were characterized by IR, ¹H and ¹³C NMR and mass spectral data. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Recommanded Product: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalyst-free water-mediated N-Boc deprotection was written by Wang, Gan;Li, Chunju;Li, Jian;Jia, Xueshun. And the article was included in Tetrahedron Letters in 2009.Category: chlorides-buliding-blocks This article mentions the following:

A catalyst-free water-mediated N-Boc deprotection of N-Boc amines is reported. In the absence of any addnl. reagents, the free amines were formed from a variety of aromatic and aliphatic N-Boc amines as well as from some N-Boc amino acid derivatives In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Category: chlorides-buliding-blocks).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics