Author: Jessica.F

Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization was written by Fulp, Jacob;He, Liu;Toldo, Stefano;Jiang, Yuqi;Boice, Ashley;Guo, Chunqing;Li, Xia;Rolfe, Andrew;Sun, Dong;Abbate, Antonio;Wang, Xiang-Yang;Zhang, Shijun. And the article was included in Journal of Medicinal Chemistry in 2018.COA of Formula: C8H7ClO3 This article mentions the following:

NLRP3 inflammasome plays critical roles in a variety of human diseases and represents a promising drug target. In this study, we established the in vivo functional activities of JC124, a previously identified NLRP3 inflammasome inhibitor from our group, in mouse models of Alzheimer’s disease and acute myocardial infarction. To understand the chem. space of this lead structure, a series of analogs were designed, synthesized, and biol. characterized. The results revealed the critical roles of the two substituents on the benzamide moiety of JC124. On the other hand, modifications on the sulfonamide moiety of JC124 are well tolerated. Two new lead compounds, 14 and 17, were identified with improved inhibitory potency (IC₅₀ values of 0.55 ± 0.091 and 0.42 ± 0.080 μM, resp.). Further characterization confirmed their selectivity and in vivo target engagement. Collectively, the results strongly encourage further development of more potent analogs based on this chem. scaffold. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2COA of Formula: C8H7ClO3).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C8H7ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Highly Stable Silver-Loaded Membrane Prepared by Interfacial Polymerization for Olefin Separation was written by Wang, Keying;Ren, Yuling;Luo, Jianquan;Zhuang, Yongbing;Feng, Shichao;Wan, Yinhua. And the article was included in Industrial & Engineering Chemistry Research in 2022.Application of 4422-95-1 This article mentions the following:

The separation of light olefins from paraffins by a silver-loaded facilitated transport membrane has received wide attention in recent years. However, the undesirable instability of carriers Ag⁺ has consistently restricted its further application. In this work, a silver-loaded facilitated transport membrane is developed by interfacial polymerization on PDMS/PSF support. A part of Ag⁺ in the prepared membrane is presented as silver(I)-polyetheramine (Ag(I)-PEA) complexes that can effectively enhance the stability of Ag⁺. To eliminate nonselective voids and bring more carriers (Ag⁺), secondary aqueous phase treatment was conducted. And the effect of PEA and TMC concentrations, ratio of PEA to AgNO₃, as well as secondary aqueous phase treatment on the gas transport is systematically investigated. The results show that the facilitated transport of Ag⁺ to C₃H₆ can offset the increase in diffusion resistance induced by the incremental membrane thickness and crosslinking degree as well as the addnl. AgCl particles on the membrane. Finally, the optimum C₃H₆/C₃H₈ selectivity of the silver-loaded membrane is trebled over the membrane without silver. Remarkably, the TMC_0.6%-PEA_10%(AgNO₃)_10:9-2/PDMS/PSF membranes show great long-term stability of about 29 days. In this work, both monomer synthesis and preparation methods are facile and versatile, presenting a promising strategy for the preparation of silver-loaded membranes with a long-term separation property. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application of 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

From alcohol to 1,2,3-triazole via a multi-step continuous-flow synthesis of a rufinamide precursor was written by Borukhova, Svetlana;Noel, Timothy;Metten, Bert;de Vos, Eric;Hessel, Volker. And the article was included in Green Chemistry in 2016.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

Rufinamide can be synthesized from 2,6-difluorobenzyl chloride in three steps. The microreactor flow networks have better sustainability profiles in terms of life-cycle assessment than the resp. consecutive processing in a batch. The anal. is based on the results of a single step conversion from batch to continuous mode. An uninterrupted continuous process towards rufinamide is developed, starting from 2,6-difluorobenzyl alc. precursor, which is converted to the corresponding 2,6-difluorobenzyl chloride with hydrogen chloride gas. The chloride is then converted to the corresponding 2,6-difluorobenzyl azide that yields the rufinamide precursor I via cycloaddition to the greenest and cheapest dipolarophile available on the market. The current process demonstrates chem. and process-design intensification aspects encompassed by novel process windows. Single reaction steps are chem. intensified via a wide range of conditions available in a microreactor environment. Meanwhile, the connection of reaction steps and separations results in process-design intensification. With two in-line separations the process consists of five stages resulting in a total yield of 82% and productivity of 9 g h^-1 (11.5 mol h^-1L^-1). The process minimizes the isolation and handling of strong alkylating or energetic intermediates, while minimizing water and organic solvent consumption. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Small-molecule Ca_Vα₁·Ca_Vβ antagonist suppresses neuronal voltage-gated calcium-channel trafficking was written by Chen, Xingjuan;Liu, Degang;Zhou, Donghui;Si, Yubing;Xu, David;Stamatkin, Christopher W.;Ghozayel, Mona K.;Ripsch, Matthew S.;Obukhov, Alexander G.;White, Fletcher A.;Meroueh, Samy O.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2018.Computed Properties of C8H4ClNO This article mentions the following:

Extracellular calcium flow through neuronal voltage-gated CaV2.2 calcium channels converts action potential-encoded information to the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, culminating in excitation of the postsynaptic central nociceptive neurons. The CaV2.2 channel is composed of a pore-forming α1 subunit (CaVα1) that is engaged in protein-protein interactions with auxiliary α2/δ and β subunits. The high-affinity CaV2.2α1-CaVβ3 protein-protein interaction is essential for proper trafficking of CaV2.2 channels to the plasma membrane. Here, structure-based computational screening led to small mols. that disrupt the CaV2.2α1-CaVβ3 protein-protein interaction. The binding mode of these compounds reveals that three substituents closely mimic the side chains of hot-spot residues located on the α-helix of CaV2.2α1. Site-directed mutagenesis confirmed the critical nature of a salt-bridge interaction between the compounds and CaVβ3 Arg-307. In cells, compounds decreased trafficking of CaV2.2 channels to the plasma membrane and modulated the functions of the channel. In a rodent neuropathic pain model, the compounds suppressed pain responses. Small-mol. α-helical mimetics targeting ion channel protein-protein interactions may represent a strategy for developing nonopioid analgesia and for treatment of other neurol. disorders associated with calcium-channel trafficking. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Computed Properties of C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Water at elevated temperatures (WET): reactant, catalyst, and solvent in the selective hydrolysis of protecting groups was written by Medina-Ramos, Wilmarie;Mojica, Mike A.;Cope, Elizabeth D.;Hart, Ryan J.;Pollet, Pamela;Eckert, Charles A.;Liotta, Charles L.. And the article was included in Green Chemistry in 2014.Recommanded Product: tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:

Water at elevated temperatures (WET) can act simultaneously as reactant, solvent, and catalyst in reaction processes. WET was successfully employed in the removal of protecting groups alleviating the need for added strong acids/bases, subsequent neutralization and waste salt elimination. The protocols for the water-mediated removal of several common protecting groups such as tert-Bu carbamates (N-Boc) from 125 to 150°, acetamide (N-Ac) at 275° and acetate esters (O-Ac) at 250° are reported for different model aryl compounds High yields and selective deprotection of one protecting group in the presence of another by simply tuning the temperature is demonstrated. To gain further insights into reaction processes, the aqueous solubilities of several of the reactants, the kinetics and mechanisms associated with some of these reactions are also discussed. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Recommanded Product: tert-Butyl (4-chlorophenyl)carbamate).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: tert-Butyl (4-chlorophenyl)carbamate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2-Chloro-9-isopropyl-N,N-dimethyl-9H-purin-6-amine was written by Rouchal, Michal;Necas, Marek;Vicha, Robert. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2010.Category: chlorides-buliding-blocks This article mentions the following:

In the title compound, C₁₀H₁₄ClN₅, the imidazole and pyrimidine rings are essentially planar [maximum deviation = 0.0013 (14) and 0.0207 (13) Å, resp.]. In the crystal, the mols. are linked by weak C-H…N interactions into chains parallel to the c axis and the crystal packing is stabilized by addnl. weak C-H…N and C-H…Cl interactions. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Category: chlorides-buliding-blocks).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper immobilized on biomimetic assembled calcium carbonate/carboxymethylcellulose hybrid: a highly active recoverable catalyst for CuAAC reactions was written by Zhang, Mingjuan;Xu, Jinxi;Zhang, Tianzhu;Li, Yiqun. And the article was included in Research on Chemical Intermediates in 2021.SDS of cas: 620-19-9 This article mentions the following:

A novel copper immobilized on biomimetic assembled CM-cellulose/calcium carbonate hybrid (Cu^II@CMC/CaCO₃) as an efficient heterogeneous catalyst for the synthesis of 1,2,3-triazoles has been described herein. The fabrication of Cu^II@CMC/CaCO₃ is accomplished through a bioinspired mineralization process using sodium CM-cellulose (CMC-Na) as the template and ion exchange agent, while the metathesis, nucleation, assemble, hybridization, and immobilization of Cu(II) occurred by successful treatment with CaCl₂, Na₂CO₃, and CuSO₄ in water at room temperature The resultant Cu^II@CMC/CaCO₃ hybrid was well characterized by various analyses such as FT-IR, XRD, SEM, EDX, EDX-mapping, TEM, and TGA techniques. In the presence of low copper loading of Cu^II@CMC/CaCO₃ hybrid, benzylic halides, azide, and alkynes proceeded smoothly to afford 1,4-disubstituted 1,2,3-triazoles in high yields. The catalyst can be conveniently recovered from the reaction mixture by filter and reused for at least 5 consecutive runs with a slight drop in its catalytic activity. The remarkable activity and stability of the catalyst may be attributed to the coordination of both carboxyl and hydroxyl groups of the hybrid of CMC/CaCO₃. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9SDS of cas: 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thioglycoluril as a highly efficient, recyclable and novel organocatalyst for N-Boc protection of amines was written by Khaksar, Samad;Vahdat, Seyed Mohammad;Tajbakhsh, Mahmood;Jahani, Fatemeh;Heydari, Akbar. And the article was included in Tetrahedron Letters in 2010.Reference of 18437-66-6 This article mentions the following:

A simple and efficient protocol for the chemoselective mono-N-Boc protection of various structurally diverse amines with di-tert-Bu dicarbonate using thioglycoluril as the catalyst is described. The catalyst can be readily separated from the reaction products by simple filtration and recovered for reuse. No competitive side reactions, such as formation of isocyanate, urea, oxazolidinone, and N,N-di-Boc derivatives were observed In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

From Sensors to Silencers: Quinoline- and Benzimidazole-Sulfonamides as Inhibitors for Zinc Proteases was written by Rouffet, Matthieu;de Oliveira, Cesar Augusto F.;Udi, Yael;Agrawal, Arpita;Sagi, Irit;McCammon, J. Andrew;Cohen, Seth M.. And the article was included in Journal of the American Chemical Society in 2010.Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:

Derived from the extensive work in the area of small mol. zinc(II) ion sensors, chelating fragment libraries of quinoline- and benzimidazole-sulfonamides have been prepared and screened against several different zinc(II)-dependent matrix metalloproteinases (MMPs). The fragments show impressive inhibition of these metalloenzymes and preferences for different MMPs based on the nature of the chelating group. The findings show that focused chelator libraries are a powerful strategy for the discovery of lead fragments for metalloprotein inhibition. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of the new morphine partial structure – 15,16-secomorphinan was written by Revesz, Laszlo. And the article was included in Helvetica Chimica Acta in 1984.Safety of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

1-Methylcyclohexene was cyclized with p-MeOC₆H₄CH₂COCl in CH₂Cl₂ containing AlCl₃ followed by oximation to give the phenanthrenone oxime I, which was reduced to give the phenanthrenamines II and III (R = R¹ = H). II and III (R = R¹ = H) were converted to II and III (R = H, R¹ = F₃CCO, cyclopropylcarbonyl; R = H, Me, R¹ = cyclopropylmethyl). (±)-15,16-Secocyclorphan (III, R = Me, R¹ = cyclopropylmethyl) has the analgesic potency of morphine and exhibites good binding to the opiate receptor. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Safety of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics