Author: Jessica.F

On-Demand Control of the Photochromic Properties of Naphthopyrans was written by Kuroiwa, Hayato;Inagaki, Yuki;Mutoh, Katsuya;Abe, Jiro. And the article was included in Advanced Materials (Weinheim, Germany) in 2019.SDS of cas: 6834-42-0 This article mentions the following:

Photofunctional compounds have emerged as critically important materials for both fundamental studies and industrial applications. Control of the thermal decoloration speed to within several seconds while sustaining satisfactory photochromic colorability is an important challenge for the application of such materials to photochromic lenses and smart windows. Photochromic naphthopyran derivatives are utilized for photochromic lenses because of their high durability and easily controllable colorability. However, the residual color imparted by the long-lived transient species upon ceasing light irradiation remains a hindrance to practical applications. In this study, a strategy is demonstrated for on-demand control of the thermal decoloration speed of the transient colored species of naphthopyran derivatives The increase in the ring-size of the alkylenedioxy moiety on the naphthopyrans accelerates the thermal back-reaction independently of the maximum-absorption wavelength of the colored isomer, leading to the realization of yellow-, red-, and blue-photochromic naphthopyrans with similar thermal fading speeds. This novel mol. design provides a strategy for the future development of advanced photoresponsive materials. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0SDS of cas: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics of peroxodisulfate oxidation of ortho-substituted N,N-dimethylanilines, and the mechanism of Boyland-Sims oxidation was written by Srinivasan, Chockalingam;Perumal, Subbu;Arumugam, Natesan. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1985.Application In Synthesis of 2-Chloro-N,N-dimethylaniline This article mentions the following:

The kinetics of oxidation of o-RC₆H₄NMe₂ (I; R = H, MeO, Me, F, Cl, Br, NO₂) by S₂O₈^2- were studied in 50% (volume/volume) H₂O-EtOH containing 0.025 mol/dm³ phosphate buffer (pH 7). The reaction is 2nd-order overall, and 1st-order in each reactant. The rate was not influenced by the presence of the free-radical inhibitor H₂C:CHCH₂OAc. An increase in the polarity of the medium enhances the rate. The reactivities of I lie in the order H > Me ≈ MeO > F > Br > Cl > NO₂. Multiple regression anal. of the rate data reveals that the rate is susceptible to significant electronic and steric effects. All these observations are rationalized on the basis of attack of the oxidant at the ipso-position of the amine. Correlation anal. of reactivity data from the literature also indicates that the mechanism involves ipso-attack and not attack on N. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Application In Synthesis of 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

8-Substituted 3,4-dihydroquinolinones as a novel scaffold for atypical antipsychotic activity was written by Singer, Jamie M.;Barr, Bridget M.;Coughenour, Linda L.;Gregory, Tracy F.;Walters, Michael A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Synthetic Route of C9H9ClO2 This article mentions the following:

Several new, potent dopamine subtype 2 (DA D₂) active compounds with serotonin subtype 2A (5-HT_2A) pharmacol. are presented. 8-Substituted 3,4-dihydroquinolinones, tetrahydroquinolines, and N-acyl tetrahydroquinolines were evaluated in primary assays. Subtle changes on this novel scaffold translated to large changes in potency and selectivity in vitro. These compounds show promise as novel atypical antipsychotics for the treatment of schizophrenia. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Synthetic Route of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-catalyzed aminocarbonylative cyclization of benzyl chlorides with 2-nitroaryl alkynes to construct indole derivatives was written by Wang, Qi;Yao, Lingyun;Wang, Jian-Shu;Ying, Jun;Wu, Xiao-Feng. And the article was included in Molecular Catalysis in 2022.HPLC of Formula: 620-19-9 This article mentions the following:

A palladium-catalyzed aminocarbonylative cyclization of benzyl chlorides RCH₂Cl (R = Ph, 3,5-dichlorophenyl, naphthalen-1-yl, etc.) with 2-nitroaryl alkynes 2-NO₂-4-R¹-5-R²C₆H₂CCR³ (R¹ = H, Me, F; R² = H, Cl; R³ = Ph, n-Bu, cyclopropyl, etc.) has been developed for the rapid construction of indole skeletons I. The reaction utilized nitroarenes as the nitrogen source, Mo(CO)₆ as both the CO surrogate and the reductant to furnish various indole derivatives I in moderate to high yields. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9HPLC of Formula: 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins was written by Povedano, Juan Manuel;Rallabandi, Rameshu;Bai, Xin;Ye, Xuecheng;Liou, Joel;Chen, Hong;Kim, Jiwoong;Xie, Yang;Posner, Bruce;Rice, Luke;De Brabander, Jef K.;McFadden, David G.. And the article was included in Journal of Medicinal Chemistry in 2020.Quality Control of 3-Chloro-5-nitrobenzoic acid This article mentions the following:

A phenotypic high-throughput screen identified a benzamide small mol. with activity against small cell lung cancer cells. A “clickable” benzamide probe was designed that irreversibly bound a single 50 kDa cellular protein, identified by mass spectrometry as β-tubulin. Moreover, the anti-cancer potency of a series of benzamide analogs strongly correlated with probe competition, indicating that β-tubulin was the functional target. Addnl. evidence suggested that benzamides covalently modified Cys239 within the colchicine binding site. Consistent with this mechanism, benzamides impaired growth of microtubules formed with β-tubulin harboring Cys239, but not β₃ tubulin encoding Ser239. We therefore designed an aldehyde-containing analog capable of trapping Ser239 in β₃ tubulin, presumably as a hemiacetal. Using a forward genetics strategy, we identified benzamide-resistant cell lines harboring a Thr238Ala mutation in β-tubulin sufficient to induce compound resistance. The disclosed chem. probes are useful to identify other colchicine site binders, a frequent target of structurally diverse small mols. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7Quality Control of 3-Chloro-5-nitrobenzoic acid).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 3-Chloro-5-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Construction of Dihydropyrido[2,3-d]pyrimidine Scaffolds via Aza-Claisen Rearrangement Catalyzed by N-Heterocyclic Carbenes was written by Dzieszkowski, Krzysztof;Baranska, Izabela;Rafinski, Zbigniew. And the article was included in Journal of Organic Chemistry in 2020.Quality Control of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

N-Heterocyclic carbenes (NHCs) catalyzing aza-Claisen rearrangement of α,β-unsaturated enals with cyclic vinylogous amides under oxidative conditions generating potentially biol. active dihydropyridinone-fused uracils have been developed. This strategy represents a unique NHC-activation-based path with the use of 6-aminouracils as stable α,β-diEWG cyclic vinylogous amides for the efficient synthesis of bicyclic N-unprotected lactams similar to those in many useful drugs. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Quality Control of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Syntheses and Structures of Ag(I)-Containing Coordination Polymers and Co(II)-Containing Supramolecular Complex Based on Novel Fulvene Ligands was written by Dong, Yu-Bin;Wang, Peng;Huang, Ru-Qi;Smith, Mark D.. And the article was included in Inorganic Chemistry in 2004.Computed Properties of C8H4ClNO This article mentions the following:

Three new rigid conjugated fulvene ligands L1-L3 were synthesized. L1 and L3 were prepared by an aroylation reaction of cyclohexyl-substituted cyclopentadienyl anions. L2 was prepared by the reaction of L1 with PhNHNH₂ in hot ethanol. Six new coordination polymers, [Ag(C₂₅H₂₀N₂O₂)(ClO₄)]·3.5C₆H₆ (1), [Ag₂(μ-C₃₁H₂₄N₄)(η²-C₆H₆)(H₂O)](ClO₄)₂·(C₆H₆)·(H₂O)_0.5 (3), [Ag(C₃₁H₂₄N₄)]SbF₆·solvate (4), [Ag(C₃₁H₂₄N₄)](SbF₆)·2C₆H₆·CH₂Cl₂ (5), [Ag(C₂₅H₂₀N₂O₂)₂]SbF₆ (6), and [Ag(C₂₅H₂₀N₂O₂)₂]SbF₆ (7), and one seven-membered cobaltacycle-containing complex, Co(C₂₅H₂₀N₂O₂)₂(EtOH)₂ (2), were obtained through self-assembly based on these three new fulvene ligands. L2-L3 and compounds 1-7 were fully characterized by IR spectroscopy, elemental anal., and single-crystal x-ray diffraction. The coordination chem. of new fulvene ligands is versatile. They can bind metal ions not only through the terminal N-donors and fulvene C atoms into organometallic coordination polymers but also through the two chelating carbonyl groups into unusual seven-membered metallo-ring supramol. complexes. In the solid state, ligands L1-L3 are luminescent. A blue-shift in the emission was observed between the free ligand L1 and the one incorporated into Co(II)-containing complex 2, and a red shift in the emission was observed between the free ligand L3 and the one incorporated into Ag(I)-containing polymeric compounds 6 and 7. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Computed Properties of C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A highly efficient heterogeneous copper-catalyzed chlorodeboronation of arylboronic acids leading to chlorinated arenes was written by He, Wen;Zhang, Rongli;Cai, Mingzhong. And the article was included in RSC Advances in 2017.Reference of 18437-66-6 This article mentions the following:

A highly efficient heterogeneous copper-catalyzed chlorodeboronation of arylboronic acids with inexpensive N-chlorosuccinimide (NCS) was achieved in MeCN in the presence of 10 mol% of L-proline-functionalized MCM-41-immobilized copper(I) complex [MCM-41-L-proline-CuCl] under mild conditions, yielding a variety of aryl chlorides in excellent yields. This method proved to be tolerant of a broad range of functional groups and particularly useful for the conversion of electron-deficient arylboronic acids to aryl chlorides, a transformation that is inefficient without copper catalysis. This heterogeneous copper catalyst can be recovered by a simple filtration of the reaction solution and recycled for at least 10 times without any decreases in activity. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors was written by Patil, Shivaputra;Kamath, Shantaram;Sanchez, Tino;Neamati, Nouri;Schinazi, Raymond F.;Buolamwini, John K.. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Quality Control of 3-Cyanobenzoyl chloride This article mentions the following:

A new series of phenanthridinone derivatives, and diketo acid analogs, as well as related phenanthrene and anthracene diketo acids have been synthesized and evaluated as HIV integrase (IN) inhibitors. Several new β-diketo acid analogs with the phenanthridinone scaffold replaced by phenanthrene, anthracene or pyrene exhibited the highest IN inhibitory potency. There is a general selectivity against the integrase strand transfer step. The most potent IN was 2,4-dioxo-4-phenanthren-9-yl-butyric acid (27f) with an IC₅₀ of 0.38 μM against integrase strand transfer. The phenanthrene diketo acids 27d-f were more potent (IC₅₀ = 2.7-0.38 μM) than the corresponding phenanthridinone diketo acid 16 (IC₅₀ = 65 μM), suggesting that the polar amide bridge in the phenanthridinone system decreases inhibitory activity relative to the more lipophilic phenanthrene system. This might have to do with the possible binding of the aryl group of the compounds binding to a lipophilic pocket at the integrase active site as suggested by the docking simulations. Mol. modeling also suggested that effectiveness of chelation of the active site Mg²⁺ contributes to IN inhibitory potency. Finally, some of the potent compounds inhibited HIV-1 replication in human peripheral blood mononuclear cells (PBMC) with EC₅₀ down to 8 μM for phenanthrene-3-(2,4-dioxo)butyric acid (27d), with a selectivity index of 10 against PBMCs. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Quality Control of 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electrochemical synthesis of CNTs-Zn: ZnO@SDS/PEG@Ni₂P nanocomposite and its application for ultrasound-assisted removal of methylene blue and investigation of its antibacterial property was written by Zalipour, Ziba;Lashanizadegan, Asghar;Sadeghfar, Fardin;Ghaedi, Mehrorang;Asfaram, Arash;Sadegh, Fatemeh. And the article was included in Environmental Nanotechnology, Monitoring and Management in 2022.Formula: C16H18ClN3S This article mentions the following:

In this research, carbon nanotubes modified with CNTs-Zn: ZnO@SDS/PEG@Ni₂P nanocomposite (NCs) were applied for removal of methylene blue (MB) following its characterization by XRD, FESEM, and EDS-mapping techniques. Using central composite design (CCD), the relationship between operational parameters like sonication time (1 to 5 min), adsorbent mass (0.1 to 0.2 g), pH (3 to 11), and initial MB concentration (2 to 10 mg L^-1) on the efficiency of the understudy system was optimized, and the maximum removal percentage of (100%) was found at 4.0 min sonication, 4 mg L^-1 MB, 0.01 g of adsorbent, and pH = 9.0. The fitting of exptl. equilibrium data reveals that the Langmuir model (R2 = 0.995) is well suited for evaluating and representing the current adsorption system’s actual behavior. Kinetic analyses that match exptl. data at different periods show the pseudo-second-order model’s (R2 = 0.998) usefulness for properly describing exptl. data. Also, Pos. ΔH° and ΔS° readings, as well as neg. ΔG° values, imply an endothermic, phys., and spontaneous activity. The adsorbent’s reusability was also tested over six periods, with a minor decline in adsorbent capacity. In addition, this substance was tested in vitro for antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria, addition, candida Albicans (C. Albicans) yeast, while exptl. results support the high efficiency of this composite for cleaning and safety improvement of water quality following its application as high-efficiency adsorbent. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Formula: C16H18ClN3S).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Formula: C16H18ClN3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics