Author: Jessica.F

Application of arbuscular mycorrhizal fungi for pharmaceuticals and personal care productions removal in constructed wetlands with different substrate was written by Hu, Bo;Hu, Shanshan;Vymazal, Jan;Chen, Zhongbing. And the article was included in Journal of Cleaner Production in 2022.Reference of 101-20-2 This article mentions the following:

This study investigated the effects of substrates (sand, perlite, vermiculite, and biochar) on the colonization of arbuscular mycorrhizal fungi (AMF) in the roots of Glyceria maxima in constructed wetlands (CWs) and the impacts of AMF inoculation on the removal of six selected pharmaceuticals and personal care products (PPCPs). Results showed that the application of adsorptive substrates (perlite, vermiculite, and biochar) in CWs had pos. effects on AMF colonization. AMF could influence the uptake and translocation of PPCPs in plant tissues. The amount of PPCPs in the roots of inoculated plants was increased by 21-193% and 67-196% in sand and vermiculite systems but decreased by 13-55% and 51-100% in perlite and biochar systems, resp., compared to the non-inoculated controls. Meanwhile, AMF enhanced the translocation of PPCPs to plant shoots, resulting in higher accumulations of PPCPs in the shoots of inoculated plants than that of non-inoculated plants. AMF had pos. effects on removing PPCPs in sand systems but insignificant effects in adsorptive substrate systems. Therefore, these results indicated that the symbiotic relationship between AMF and plant roots could affect the accumulation and translocation of PPCPs in plants, and substrate type can influence this function. This study could be a starting point for exploring the potential role of AMF in PPCPs removal in CWs. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Reference of 101-20-2).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 101-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Phenylalanine stabilized copper nanoclusters for specific destruction of Congo red and bacteria in aqueous solution was written by Wang, Yong;Tan, Yiyun;Ding, Yue;Fu, Lixian;Qing, Weixia. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2022.Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

A simple preparation method of phenylalanine stabilized copper nanoclusters (Phe-CuNCs) was reported. The Phe-CuNCs were active for specific destruction of Congo red (CR) in aqueous solution under natural light irradiation, showing fast, efficient and stable catalytic activities. The catalytic reaction followed first-order kinetics equation, and a linear relation of ln (At/A0) vs. time was observed The Phe-CuNCs obtained more electrons to accelerate decolorization of CR in the presence of H2O2. The catalytic efficiency of Phe-CuNCs remained above 70% even after 10 cycles of reactions, showing economy and efficiency. The Phe-CuNCs showed remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus. Meanwhile, the bacterial damage was visualized by SEM (SEM). In addition, the Phe-CuNCs are not toxic to normal cells (HL-7702) and tumor cells (HepG2) even at high concentrations, whereas Phe-CuNCs can efficiently kill bacteria. Thus, Phe-CuNCs may be a promising nanomaterial for specific degradation of Congo red in aqueous solution as well as an adjuvant for treatment of microbial infections. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors was written by Bandarage, Upul K.;Cao, Jingrong;Come, Jon H.;Court, John J.;Gao, Huai;Jacobs, Marc D.;Marhefka, Craig;Nanthakumar, Suganthi;Green, Jeremy. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Safety of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Rho kinase (ROCK) inhibitors are potential therapeutic agents for the treatment of a variety of disorders including hypertension, glaucoma and erectile dysfunction. Here we disclose a series of potent and selective ROCK inhibitors based on a substituted 7-azaindole scaffold. Substitution of the 3-position of 7-azaindole led to compounds such as 37, which possess excellent ROCK inhibitory potency and high selectivity against the closely related kinase PKA. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Safety of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Line ferries and cargo ships for the monitoring of marine contaminants of emerging concern: Application along a Europe-Arctic transect was written by Brumovsky, Miroslav;Becanova, Jitka;Sanka, Ondrej;Loeken, Katharina Bjarnar;Baho, Didier L.;Soerensen, Kai;Nizzetto, Luca. And the article was included in Journal of Hazardous Materials in 2022.Recommanded Product: 101-20-2 This article mentions the following:

Contaminants of emerging concern (CEC) are a focus in marine protection. Several CECs are released with wastewater effluents to coastal environments and their offshore occurrence has been recently documented. Routine monitoring is key for implementing marine protection acts, however infrastructural, financial, and tech. limitations hinder this task along broad spatial transects. Here we show the efficacy of a new infrastructure enabling unmanned sampling of surface water from ships of opportunity in providing reliable and cost-effective routine monitoring of CECs along a Europe-Arctic transect. The distribution and long-range transport of several pharmaceuticals and personal care products, artificial food additives, and stimulants were assessed. Validation of operations through strict procedural and anal. quality criteria is presented. A framework to estimate a compound-specific spatial range (SR) index of marine long-range transport based on monitoring results and information on source spatial distribution, is introduced. Estimated SR values ranged 50-350 km depending on compound, yielding a ranking of long-range transport potential which reflected expectations based on degradation half-lives. SR values were used to calculate prior maps of detection probability that can be used to plan future routine monitoring in the region. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Recommanded Product: 101-20-2).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 101-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents was written by Wrobel, Jay;Dietrich, Arlene;Woolson, Shiela A.;Millen, Jane;McCaleb, Michael;Harrison, Maria C.;Hohman, Thomas C.;Sredy, Janet;Sullivan, Donald. And the article was included in Journal of Medicinal Chemistry in 1992.Computed Properties of C8H6ClFO2 This article mentions the following:

Compounds from two novel series of spirosuccinimides were prepared Analogs I (R = alkyl, aralkyl; R¹ = H, 4-, 5-, 6-, 7-Cl, 5,6-Cl₂, 6-F, 5-Br, 4-, 5-Me, 6-Co₂Me, 5,6-benzo, 5-Ph, 5-MeO, 5-MeS, 6-O₂N) possessed a spiro-fused isoindolone moiety while analogs II (R = alkyl, aralkyl) contained a spiro-fused benzisothiazole S,S-dioxide group. I and II were evaluated as aldose reductase inhibitors (ARI) in vitro by their ability to inhibit glyceraldehyde reduction using a partially purified bovine lens aldose reductase preparation and in vivo as inhibitors of galactitol accumulation in the lens, sciatic nerve, and diaphragm of galactose-fed rats. Many members from the isoindolone series I, particularly those with R = Me, showed good in vitro and in vivo potency. The most potent member, I (R = Me, R¹ = 6-Cl) (III), was resolved, and aldose reductase activity was found to reside almost exclusively in the (+)-enantiomer. III was approx. equipotent in the sciatic nerve of the galactose-fed rat to other cyclic imide ARI’s of similar in vitro activity, namely sorbinil and ADN-138 and also to tolrestat, an acetic acid-based ARI (ED₅₀ = 4-8 mg/kg). Compounds from both series I and II also lower plasma glucose levels of genetically obese db/db and ob/ob mice with potency similar to that of ciglitazone. However, members from these series failed to lower insulin levels of the ob/ob mouse at the doses tested. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3Computed Properties of C8H6ClFO2).

Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C8H6ClFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mild and Efficient Synthesis of 5-(2,2-difluoro-1-phenyl cyclopropyl)-N-substituted-1,3,4-oxadiazol-2-amines via Graphene Oxide as Catalyst under Ultrasonic Irradiation Conditions was written by Reddy, Sirigireddy Sudharsan;Reddy, Bijivemula N.;Reddy, Peddiahgari Vasu Govardhana;Reddy, Gajulapalli Vishwakshan;Sarma, Loka Subramanyam. And the article was included in ChemistrySelect in 2017.Product Details of 6590-96-1 This article mentions the following:

A series of novel 5-(2,2-difluoro-1-phenylcyclopropyl)-N-substituted-1,3,4-oxadiazol-2-amines were synthesized from the reaction of 2,2-difluoro-1-phenylcyclopropane carbohydrazide and various isothiocyanates in the presence of graphene oxide (GO) and 1,8-diazabicyclo [5.4.0]undec-7-ene (DBU) under conventional and ultrasonic irradiation conditions. It was found that the reaction was completed in a short period of time with good to excellent yields by virtue of attributes offered by GO catalyst. Further, the reaction underwent smoothly in ethanol and ionic liquids Noteworthy, GO can be recycled and reused for five cycles without considerable loss in activity. The oxidative activity and morphol. of GO catalyst was confirmed by transmission electron microscopy (TEM), high resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), Fourier transform IR spectroscopy (FT-IR) and cyclic voltammetry (CV) techniques. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Product Details of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Comparative antioxidant, anticancer and antimicrobial activities of essential oils from Semen Platycladi by different extraction methods was written by Zhu, Jing-Jing;Yang, Jing-Juan;Wu, Guo-Jie;Jiang, Jian-Guo. And the article was included in Industrial Crops and Products in 2020.Recommanded Product: 1-Chlorooctadecane This article mentions the following:

Semen Platycladi is a highly valued seed tonic from the Cupressaceae Platycladus orientalis (L.) Franco, which contains abundant essential oils exhibiting antioxidant, antimicrobial, sedative and hypnotic potency. The study was formulated to estimate the potential antioxidant, anticancer and antibacterial activities of its essential oils as well as its correlation with chem. constituents. The comparison of three isolation methods including steam distillation extraction, heating reflux extraction, and Soxhlet extraction of ethanol was carried out to isolate essential oils whose chem. composition were identified and evaluated by Gas Chromatog.-Mass Spectrometer. It turned out that the yield of essential oils obtained through heating reflux extraction and Soxhlet extraction was almost 40 % higher than those extracted by steam distillation extraction in nearly one-quarter of a time used by the steam distillation extraction A total of 76 compounds were identified, including ten alkanes, 14 alkenes, 13 alcs., one aldehyde ketone, three ethers, one acid, 17 esters, five aromatic compounds, and 12 others. The essential oils extracted by steam distillation extraction were proved to have the best antioxidant and antimicrobial activity although with the lowest yield. Scanning electron microscopic observation displayed that the of S. aureus revealed serious disruption of cell membranes resulting in the loss of cell viability. Therefore, it′s vital to adopt a proper method to obtain the target ingredients recommended as nutraceuticals and/or phytomedicines. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Recommanded Product: 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, antifungal evaluation, and molecular docking of novel 1,2,4-triazole derivatives containing oxime ether and cyclopropyl moieties as potential sterol demethylase inhibitors was written by Sun, Sheng-Xin;Yan, Jing-Hua;Zuo, Jiang-Tao;Wang, Xiao-Bin;Chen, Min;Lu, Ai-Min;Yang, Chun-Long;Li, Guo-Hua. And the article was included in New Journal of Chemistry in 2021.SDS of cas: 620-19-9 This article mentions the following:

In the search for novel sterol demethylase inhibitors (DMIs), a series of 1,2,4-triazole derivatives containing oxime ether and cyclopropyl moieties I (R = Ph, 2,4,6-trichlorophenyl, 2-(1,3-dimethoxy-3-oxoprop-1-en-2-yl)benzen-1-yl, etc.) were designed using the bioactive substructure combination assisted by virtual mol. docking. The antifungal evaluation against Rhizoctonia solani (Rs), Fusarium graminearum (Fg), and Botrytis cinerea (Bc) indicated that most of the target compounds exhibited remarkable inhibitory activities against the above-mentioned tested fungi. Significantly, the compound I (R = 2,6-dichlorophenyl) exhibited outstanding anti-Fg activity with an EC₅₀ value of 1.22μg mL^-1 in vitro, and a protective effect of 59.45% in vivo at 200μg mL^-1. Further investigation revealed that compound I (R = 2,6-dichlorophenyl) evidently inhibited Fg spore germination and caused some wrinkles and dents on the surface of mycelia. Mol. docking showed that compound I (R = 2,6-dichlorophenyl) bound with the target protein FgCYP51 via coordination, hydrogen bonding and stacking interactions that were similar, but slightly different from the interactions of tebuconazole with FgCYP51. These research results suggested that the target compounds I are valuable for the further structural optimization of novel triazole fungicides. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9SDS of cas: 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.SDS of cas: 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Visible-light promoted intermolecular halofunctionalization of alkenes with N-halogen saccharins was written by Song, Lu;Luo, Sanzhong;Cheng, Jin-Pei. And the article was included in Organic Chemistry Frontiers in 2016.Application In Synthesis of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

A simple and efficient visible-light promoted intermol. haloamination and haloetherification of alkenes using N-halosaccharin as the halogen and nitrogen/oxygen source (halo = Br, Cl) was reported. The reaction was applied to a very broad range of alkenes to generate haloamines and haloethers with high isolated yields. With DBU as the base, metal-free C-H amination of aryl olefins was achieved with good yields. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Application In Synthesis of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Base-Promoted Metal-/Oxidant-Free Three-Component Tandem Annulation: A Strategy for the Construction of 2,4,5-Trisubstituted Thiazoles via C-N Bond Cleavage of Amidines was written by Guo, Wei;Zhao, Mingming;Tan, Wen;Zheng, Lvyin;Tao, Kailiang;Chen, Luyan;Wang, Mingfeng;Chen, Deliang;Fan, Xiaolin. And the article was included in Asian Journal of Organic Chemistry in 2018.HPLC of Formula: 18637-02-0 This article mentions the following:

A base-promoted and metal-/oxidant-free one-pot three-component tandem annulation of amidines, aryl/alkyl isothiocyanates, and α-bromoesters/ketones to 2,4,5-trisubstituted thiazoles I (R¹ = Ph, 4-FC₆H₄, 3-BrC₆H₄, etc.; R² = 4-FC₆H₄, 4-EtC₆H₄, 2-ClC₆H₄, etc.; R³ = OEt, 4-NCC₆H₄, 3-FC₆H₄, etc.) is described. This operationally simple protocol involves a base-promoted C-N bond cleavage of amidines and features readily available starting materials, excellent functional group tolerance, and high step-economy. It leads to the preparation of 2,4,5-trisubstituted thiazoles efficiently and has potential applications in the field of drug screening and modification. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0HPLC of Formula: 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics