Author: Jessica.F

A versatile living polymerization method for aromatic amides was written by Pal, Subhajit;Nguyen, Dinh Phuong Trinh;Molliet, Angelique;Alizadeh, Mahshid;Crochet, Aurelien;Ortuso, Roberto D.;Petri-Fink, Alke;Kilbinger, Andreas F. M.. And the article was included in Nature Chemistry in 2021.Computed Properties of C19H15Cl This article mentions the following:

Polycondensation polymers typically follow step-growth kinetics assuming all functional groups are equally likely to react with one another. If the reaction rates with the chain end can be selectively accelerated, living polymers can be obtained. Here we report on two chlorophosphonium iodide reagents that have been synthesized from triphenylphosphine and tri(o-methoxyphenyl)phosphine. The former activates aromatic carboxylic acids as acid chlorides in the presence of secondary aromatic amines and the latter even in the presence of primary aromatic amines. These reagents allow p-aminobenzoic acid derivatives to form solution-stable activated monomers that polymerize in a living fashion in the presence of amine initiators. Other aryl amino acids and even dimers of aryl amino acids can be polymerized in a living fashion when slowly added to the phosphonium salt in the presence of an amine initiator. Diblock copolymers and triblock terpolymers of aryl amino acids can be prepared even in the presence of electrophilic functional groups. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Computed Properties of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Installation of synergistic binding sites onto porous organic polymers for efficient removal of perfluorooctanoic acid was written by Liu, Xiongli;Zhu, Changjia;Yin, Jun;Li, Jixin;Zhang, Zhiyuan;Li, Jinli;Shui, Feng;You, Zifeng;Shi, Zhan;Li, Baiyan;Bu, Xian-He;Nafady, Ayman;Ma, Shengqian. And the article was included in Nature Communications in 2022.Product Details of 76-83-5 This article mentions the following:

Herein, we report a strategy to construct highly efficient perfluorooctanoic acid (PFOA) adsorbents by installing synergistic electrostatic/hydrophobic sites onto porous organic polymers (POPs). The constructed model material of PAF-1-NDMB (NDMB = N,N-dimethyl-butylamine) demonstrates an exceptionally high PFOA uptake capacity over 2000 mg g^-1, which is 14.8 times enhancement compared with its parent material of PAF-1. And it is 32.0 and 24.1 times higher than benchmark materials of DFB-CDP (β-cyclodextrin (β-CD)-based polymer network) and activated carbon under the same conditions. Furthermore, PAF-1-NDMB exhibits the highest k₂ value of 24,000 g mg^-1 h^-1 among all reported PFOA sorbents. And it can remove 99.99% PFOA from 1000 ppb to <70 ppt within 2 min, which is lower than the advisory level of Environmental Protection Agency of United States. This work thus not only provides a generic approach for constructing PFOA adsorbents, but also develops POPs as a platform for PFOA capture. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Product Details of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalytic enantioselective synthesis of carboxy-substituted 2-isoxazolines by cascade oxa-Michael-cyclization was written by Lee, Hyo-Jun;Eun, Bora;Sung, Eonseon;Hwang, Gil Tae;Ko, Young Kwan;Cho, Chang-Woo. And the article was included in Organic & Biomolecular Chemistry in 2018.Product Details of 697-73-4 This article mentions the following:

An efficient quinidine-based phase-transfer-catalyzed enantioselective cascade oxa-Michael-cyclization reaction of hydroxylamine with various β-carboxy-substituted α,β-unsaturated ketones has been achieved for the preparation of chiral carboxy-substituted 2-isoxazolines. This cascade reaction provided the desired products in good yields (up to 98%) with excellent enantioselectivities (91-96% ee). In addition, the cascade reaction was effectively applied to the first catalytic asym. synthesis of the herbicide (S)-methiozolin. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Product Details of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, and characterization of rhein analogs as novel inhibitors of scavenger receptor A was written by Zheng, Yi;Li, Xia;Pagare, Piyusha P.;Yuan, Yunyun;Wang, Xiang-Yang;Zhang, Yan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Reference of 90064-48-5 This article mentions the following:

Scavenger receptor A (SRA) has been known as an immunosuppressive factor and therefore therapeutic inhibition of SRA may be potentially exploited for cancer immunotherapy. The previous work suggested that rhein may act as an inhibitor of SRA in reversing immunosuppression of SRA during T cells activation. Herein, three deconstruction analogs of rhein were further studied as inhibitors of SRA. These three compounds, particularly compound I, also known as a natural product danthron, enhanced T cells activation, indicated by increased transcriptional activation of interleukin 2 (Il2) gene, production of IL-2 protein, and proliferation of T cells. Addnl., the interaction between these compounds and SRA was studied by mol. modeling. Compound I showed a favorable binding mode with the cysteine rich domain of SRA protein compared to the other compounds Collectively, those results would provide insight for future design and development of next generation rhein derivatives as SRA inhibitors. In the experiment, the researchers used many compounds, for example, 4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5Reference of 90064-48-5).

4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 90064-48-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of tosufloxacin p-tosylate was written by Liu, Mingliang;Sun, Lanying;Wei, Yonggang;Guo, Huiyuan. And the article was included in Zhongguo Yiyao Gongye Zazhi in 2003.Safety of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:

The title compound was prepared from Et 2,6-dichloro-5-fluoronicotinoylacetate via condensation with CH(OEt)₃, 2,4-difluoroaniline displacement, cyclization, condensation with 3-aminopyrrolidine and hydrolysis in overall yield 72.6%. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Safety of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Age, gender, and racial/ethnic differences in the association of triclocarban with adulthood obesity using NHANES 2013-2016 was written by Uche, Uloma Igara;King, Christopher C.. And the article was included in Archives of Environmental & Occupational Health in 2022.Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea This article mentions the following:

This study examined the association between triclocarban and obesity among US adults and compared the pattern of this association across age, gender, and racial/ethnic groups. Study found triclocarban to be associated with obesity (OR: OR:1.123 95% CI: 1.046, 1.205) and this association remained among women (OR:1.14 95% CI: 1.031, 1.261). Study participants aged 60 years and older were more likely to be overweight (OR:1.131 95% CI: 1.022 1.251) and obese (OR:1.192 95% CI: 1.079, 1.317) when compared to other age groups. Likewise, non-Hispanic whites (OR:1.126 95% CI: 1.003, 1.263) and “other race including multi-racial” (OR:1.431 95% CI: 1.219, 1.679) were more likely to be obese when compared to other racial/ethnic groups. In conclusion, triclocarban is associated with obesity among US adults and there is evidence of gender, age, and racial/ethnicity differences in the association In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Effect of exogenous nitric oxide on the volatile components in the petals of peony was written by Wang, Juan. And the article was included in Henong Xuebao in 2014.Recommanded Product: 3386-33-2 This article mentions the following:

To explore the effect of exogenous nitric oxide on volatile components in the petals of peony, 0.2 mmol·L^-1 nitric oxide (NO) donor sodium nitroprusside (SNP) was used to spray whole plant leaves in bud stage. SPME-GC-MS was used to determine the volatile components in petals of tree peony. Sixty-two kinds of volatile components were detected in the different blooming stages of peony and SNP treatment, including alkanes, terpenes, arenes, alcs., esters, ketones and heterocycles. Alkanes and terpenes were the most volatile components, and the most was at full bloom stage. Exogenous NO treatment reduced the types of alkanes, alcs. and early arenes at the petals of all blooming stages. There was no evident impact on the terpenes and ketones with esters wasn’t detected. NO treatment increased the alkanes content at full-bloom stage, decreased the contents of the terpenes, alcs. and arenes at the beginning bloom stage. Therefore, the type and content of volatile component were influenced by exogenous NO in petals of tree peony at different flowering stages. There was most influence at full blooming stage, followed by the beginning bloom stage. The impact on the end bloom stage was the min. This study will provide certain theor. basis for the development and utilization of peony flower. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Recommanded Product: 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Highly twisted adamantyl arotinoids: Synthesis, antiproliferative effects and RXR transactivation profiles was written by Perez-Rodriguez, Santiago;Ortiz, Maria A.;Pereira, Raquel;Rodriguez-Barrios, Fatima;de Lera, Angel R.;Piedrafita, F. Javier. And the article was included in European Journal of Medicinal Chemistry in 2009.COA of Formula: C9H9ClO3 This article mentions the following:

I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH) and II (R = H, MeOCH₂CH₂OCH₂) are prepared as novel adamantyl biaryl arotinoids with decreased binding to retinoic acid receptors but with anticancer activity (by selective induction of apoptosis in cancer cells). I and II are prepared using Suzuki coupling reactions of an adamantylphenylboronic acid with a trifloxyphenylacetate, a trifloxycinnamate, and a trifloxynaphthoate. I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH) show significant antiproliferative activity in several human cancer cell lines, with the anticancer activity correlated to the induction of apoptosis as measured by caspase activity. I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH), while devoid of retinoic acid receptor binding capacity, transactivate the retinoid X receptor α. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5COA of Formula: C9H9ClO3).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C9H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Amide Effects in C-H Activation: Noncovalent Interactions with L-Shaped Ligand for meta Borylation of Aromatic Amides was written by Bisht, Ranjana;Hoque, Emdadul Md;Chattopadhyay, Buddhadeb. And the article was included in Angewandte Chemie, International Edition in 2018.SDS of cas: 1711-11-1 This article mentions the following:

Borylated aromatic amides 3-pinBC₆H_4-nX_nCONR₂ (6a–t; X = halo, CN, Ph, benzo, MeO) were prepared by meta C-H activation/borylation of amides X_nC₆H_5-nCONR₂ with B₂pin₂, catalyzed by [Ir₂(cod)₂(μ-OMe)₂]/L¹ with up to 99% regioselectivity. A new concept for the meta-selective iridium-catalyzed borylation of aromatic amides is described. It has been demonstrated that while esters gave para-borylated products, amides lead to meta borylations. For achieving high meta selectivity, an L-shaped bifunctional ligand I (L¹) has been employed and engages in an O…K noncovalent interaction with the oxygen atom of the moderately distorted amide carbonyl group. This interaction provides exceptional control for providing up to 99% selective formation of meta-borylated products. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1SDS of cas: 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics