Author: Jessica.F

Jones, F. William published the artcileFiber-reactive insect-resist agents for wool: the synthesis and effectiveness of some organophosphorus compounds, Related Products of chlorides-buliding-blocks, the publication is Pesticide Science (1982), 13(6), 602-10, database is CAplus.

Fiber-reactive derivatives of 10 organophosphorus compounds were synthesized and evaluated as insect-resistant agents for wool. Some were very effective against wool pests and, when the fiber-reactive group was a 2-bromoacrylic ester group, these compounds also exhibited good fastness to washing and dry-cleaning.

Pesticide Science published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bendale, Pravin published the artcileSecond Generation Tetrahydroquinoline-Based Protein Farnesyltransferase Inhibitors as Antimalarials, Quality Control of 10543-42-7, the publication is Journal of Medicinal Chemistry (2007), 50(19), 4585-4605, database is CAplus and MEDLINE.

Substituted tetrahydroquinolines (THQs) have been previously identified as inhibitors of mammalian protein farnesyltransferase (PFT). Previously it was shown that blocking PFT in the malaria parasite led to cell death and that THQ-based inhibitors are the most potent among several structural classes of PFT inhibitors (PFTIs). THQ-based PFTIs, e.g., I, were synthesized and several compounds were discovered that inhibit the malarial enzyme in the sub- to low-nanomolar range and that block the growth of the parasite (P. falciparum) in the low-nanomolar range. This body of structure-activity data can be rationalized in most cases by consideration of the X-ray structure of one of the THQs bound to mammalian PFT together with a homol. structural model of the malarial enzyme. The results of this study provide the basis for selection of antimalarial PFTIs for further evaluation in preclin. drug discovery assays.

Journal of Medicinal Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Quality Control of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sano, Mitsuji published the artcileIdentification of carpronium chloride and its metabolite in human urine by field desorption mass spectrometry using deuterium labeling, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Biomedical Mass Spectrometry (1979), 6(11), 467-71, database is CAplus and MEDLINE.

After oral administration of carpronium chloride [13254-33-6], it and a major metabolite N-(3-carbohydroxypropyl)trimethylammonium chloride [6249-56-5] were identified in urine by field desorption mass spectrometry using D labeling. Purification from urine included ion pair extraction with an iodine reagent.

Biomedical Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sano, Mitsuji published the artcileField desorption mass spectrometry of betaine hydrohalides, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Biomedical Mass Spectrometry (1982), 9(10), 438-42, database is CAplus.

The field desorption mass spectra of betaine hydrohalides (e.g. Me₃N⁺CH₂CO₂H Cl^–) and I were examined Field desorption ions, [betaines +H]⁺, and cluster ions, [nbetaines +H]⁺, were generally observed In compounds where the conformation between the quaternary ammonium N atom and the CO₂H group prohibits betaine formation, the spectra consist only of complex field desorption ions due to thermal decomposition products. Quaternary ammonium cations and cluster ions which arise from ordinary quaternary ammonium compounds are hardly produced. The effect of counter ions and the mechanism of field desorption ion formation are discussed.

Biomedical Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Komatsu, Ryutaro published the artcileManipulating the Electronic Excited State Energies of Pyrimidine-Based Thermally Activated Delayed Fluorescence Emitters To Realize Efficient Deep-Blue Emission, Recommanded Product: 4-Chloro-2-methylphenylboronic acid, the publication is ACS Applied Materials & Interfaces (2017), 9(5), 4742-4749, database is CAplus and MEDLINE.

The electronic excited state energies of pyrimidine-based TADF emitters were molecularly manipulated to realize deep-blue emission and reduced delayed fluorescent lifetime (τ_d). The authors then systematically studied the relations among the chem. structure, properties, and device performances. The resultant novel pyrimidine emitters, called Ac-XMHPMs (X = 1, 2, and 3), contain different numbers of bulky Me substituents at acceptor moieties, increasing the excited singlet (E_S) and triplet state (E_T) energies. Among them, Ac-3MHPM, with a high E_T of 2.95 eV, exhibited a high external quantum efficiency (η_ext,max) of 18% and an η_ext of 10% at 100 cd m^-2 with Commission Internationale de l’Eclairage chromaticity coordinates of (0.16, 0.15). These efficiencies are among the highest values to date for deep-blue TADF OLEDs. The mol. design strategy provides fundamental guidance to design novel deep-blue TADF emitters.

ACS Applied Materials & Interfaces published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Recommanded Product: 4-Chloro-2-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Karabayir, Ali published the artcileInfluence of disinfectant added to drinking water on quail growth performance and egg quality, Related Products of chlorides-buliding-blocks, the publication is Fresenius Environmental Bulletin (2018), 27(5), 3051-3058, database is CAplus.

In the present study, the effect of disinfectant addition into drinking water on quail (Coturnix coturnix japonica) growth performance, egg quality, and water quality parameters was investigated. Drinking water quality was pos. affected by addition of disinfectant (sodium N-chloro-p-toluenesulfonamide trihydrate). Microbial load of drinking water was reduced by disinfectant addition Feed intake of the quails provided with disinfected drinking water was lower, while water intake and live weight gain was similar between the trial groups. Quail egg quality was affected by addition of disinfectant. The eggs of the quails provided disinfected drinking water had lower egg weight, shell strength and thickness, but the protein and mineral composition was not affected by disinfectant addition The Haugh units of the eggs of the quails provided with disinfected water were higher, thus these types of eggs could be readily more suitable for the bakery industry. It can be concluded that addition of disinfectant into quail drinking water may improve the status and egg quality of quails.

Fresenius Environmental Bulletin published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wakatake, Takanori published the artcileAn auxin transport network underlies xylem bridge formation between the hemi-parasitic plant Phtheirospermum japonicum and host Arabidopsis, Product Details of C8H7ClO3, the publication is Development (Cambridge, United Kingdom) (2020), 147(14), dev187781, database is CAplus and MEDLINE.

Parasitic plants form vascular connections with host plants for efficient material transport. The haustorium is the responsible organ for host invasion and subsequent vascular connection. After invasion of host tissues, vascular meristem-like cells emerge in the central region of the haustorium, differentiate into tracheary elements and establish a connection, known as a xylem bridge, between parasite and host xylem systems. Despite the importance of this parasitic connection, the regulatory mechanisms of xylem bridge formation are unknown. Here, we show the role of auxin and auxin transporters during the process of xylem bridge formation using an Orobanchaceae hemiparasitic plant, Phtheirospermum japonicum. The auxin response marker DR5 has a similar expression pattern to tracheary element differentiation genes in haustoria. Auxin transport inhibitors alter tracheary element differentiation in haustoria, but biosynthesis inhibitors do not, demonstrating the importance of auxin transport during xylem bridge formation. The expression patterns and subcellular localization of PIN family auxin efflux carriers and AUX1/LAX influx carriers correlate with DR5 expression patterns. The cooperative action of auxin transporters is therefore responsible for controlling xylem vessel connections between parasite and host.

Development (Cambridge, United Kingdom) published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C6H4ClNO2, Product Details of C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Walton, E. published the artcileNew analgesics. III. Homologs of amidone, isoamidone, and some related compounds, Product Details of C5H13Cl2N, the publication is Journal of the Chemical Society (1949), 648-55, database is CAplus.

cf. C.A. 42, 6814d. In view of the established value of amidone (Me₂NCHMeCH₂CPh₂COEt) as an analgesic, 4 series of related ketones have been prepared by condensing Ph₂CHCN with a Cl base and treating the resulting basic cyanides with Grignard reagents. In general, the analgesic and respiratory depression activities remain associated but not always in the same ratio, maximum activity being attained in the Et ketone in all 4 series. Data are given for the analgesic activity, respiratory depression activity, approx. LD₅₀ (i.v. injection into mice), and toxic concentration on isolated rabbit heart. MeCH(NMe₂)CH₂OH (32 g.) and 46 mL. SOCl₂ in 120 mL. CHCl₃, warmed 3 h., give 1-chloro-2-(dimethylamino)propane-HCl, deliquescent, m. 101-2°; heated 3 min. at 140-60°, it yields MeCHClCH₂NMe₂.HCl (not changed by heating at 190-200°), which results also from MeCH(OH)CH₂NMe₂ and SOCl₂. A mixture of 26 g. Me₂NCHMeCH₂CPh₂CN (I) and Me₂NCH₂CHMeCPh₂CN (II) (prepared by the German process, Rept. Number P.B. 981, Office of the Pub. Board, Wash., D. C., p. 84) crystallized from petr. ether (b. 60-80°), gives 13.5 g. I, m. 90-1° (HCl salt, m. 181-3°; HBr salt, m. 175°; HI salt, cream, m. 203-4°; nitrate, m. 168-70° (decomposition); methiodide, m. 238-46°); the oil from the mother liquor of I, treated with 40% HBr, gives 14 g. of the HBr salt, m. 223-4°, of II, m. 68-9°; HCl salt, m. 224-5°; HI salt, m. 212-13°; nitrate, m. 178° (decomposition); H D-tartrate, m. 88-98°; methiodide, m. 235-45°. I (5 g.) in 20 mL. xylene and MeMgI (7.7 g. MeI), heated 2 h. on the steam bath (ether allowed to evaporate) and 2 h. on a sand bath, give 5-dimethylamino-3,3-diphenyl-2-hexanone, m. 72-3° (HCl salt, m. 185-7°; HBr salt, m. 193-5°; HI salt, m. 180-2°). Amidone (III) (m. 80-2°) yields a HI salt, m. 198-9°, a nitrate m. 108-10° (decomposition), and a methiodide, m. 168-70°. I and PrMgI give 7-dimethylamino-5,5-diphenyl-4-octanone which yields a nitrate, m. 95-7°, a HI salt, m. 155-7°, and a HBr salt, m. 87-9°. I and iso-PrMgBr give 6-dimethylamino-4,4-diphenyl-2-methyl-3-heptanone, b₄ 176-86° (nitrate, m. 116-18°). I and BuMgI yield 2-dimethylamino-4,4-diphenyl-5-nonanone, characterized as the HCl salt, m. 83-6°; HBr salt, m. 103-5°; HI salt, m. 140-3°, and nitrate, m. 77-8°. I and PhMgBr give the intermediate ketimine (C₂₅H₂₈N₂.HCl), m. 136-8°; refluxed 2 h. with 20% HBr, this yields the HBr salt, m. 181-3°, of Ph 3-dimethylamino-1,1-diphenylbutyl ketone; HCl salt, m. 197-8°. I and PhCH₂MgBr give 5-dimethylamino-1,3,3-triphenyl-2-hexanone-HCl, m. 236-7°; HBr salt, m. 243-4°. I (40 g.) and 21.6 g. D-tartaric acid in 430 mL. Me₂CO and 10 mL. H₂O, kept 24 h. at 0°, give 28 g. of the H D-tartrate, m. 109-12°, [α]_D²⁰ 16° (H₂O), of (-)-I, m. 99-101°, [α]_D²¹ -51° (EtOH); the Me₂CO mother liquors plus a little ether, kept 4 days at 0°, give 14 g. of the H D-tartrate, m. 66-70°, [α]_D²⁰ 5° (H₂O), of (+)-I, m. 101°, [α]_D²² 49° (EtOH); HBr salt, m. 216-18°, [α]_D²² 5 (EtOH), -4° (H₂O); nitrate, m. 169-71° (decomposition), [α]_D²⁰ 5° (EtOH), -6° (H₂O). (-)-I and EtMgBr give (-)-III, m. 99-101°, [α]_D²² -32° (EtOH); HBr salt, m. 234-5°, [α]_D²² -134° (EtOH); HCl salt, m. 241-2° (decomposition), [α]_D²¹ -130° (H₂O). (+)-III, m. 98-100°, [α]_D²⁰ 28° (EtOH); HI salt, m. 175-7° (decomposition); nitrate, m. 148° (decomposition), [α]_D¹⁹ 137° (EtOH). I (2 g.), 4 mL. concentrated H₂SO₄, and 4 mL. H₂O, refluxed 20 min., give 2.3 g. of the acid sulfate, m. 222-3°, of γ-dimethylamino-α,α-diphenylvaleric acid (IV), m. 198-9° (decomposition); HCl salt, m. 213-16°; the mother liquor yields the amide, m. 175-6° (HCl salt, m. 190-1°); Me ester, m. 60-5° [HCl salt, m. 166-8° (decomposition); HBr salt, m. 182° (decomposition)]; Et ester, an oil (HBr salt, m. 167-8°). I (5 g.), 0.7 g. NaNH₂, and 10 mL. PhMe, refluxed 6-7 h., give 2.5 g. I and 3-dimethylamino-1,1-diphenylbutane, whose HBr salt m. 159-60°; it results also on heating IV 15 min. at 200°; methiodide, m. 195-6°. IV (0.8 g.) and 0.5 mL. SOCl₂ in CHCl₃, warmed 4 h. on the steam bath, give 3,3-diphenyl-1,5-dimethyl-2-pyrrolidone, m. 122-3°. II and MeMgI in xylene, heated 1 h. on the steam bath and refluxed 1 h., give the ketimine (methiodide, C₂₁H₂₉N₂I, decompose 176-230°), which yields 5-dimethylamino-3,3-diphenyl-4-methyl-2-pentanone, m. 61-5° (HBr salt, m. 194-6°). II (16.6 g.) and EtMgBr give the ketimine, b₁ 94° (methiodide, m. 240°); refluxed 2.5 h. with 20% HBr, it yields 10.3 g. 6-dimethylamino-4,4-diphenyl-5-methyl-3-hexanone-HBr, m. 139-44°; HI salt, m. 206-8°; nitrate, m. 182-3° (decomposition); H D-tartrate, m. 150-4°. II (16.6 g.) and PrMgBr give 3.75 g. of the HCl salt, m. 80-100°, of 1-dimethylamino-3,3-diphenyl-2-methyl-4-heptanone, m. 100-1°. II and 5 mols. iso-PrMgBr give 6-dimethylamino-4,4-diphenyl-2,5-dimethyl-3-hexanone, whose HBr salt m. 81-5°. II and excess 48% HBr, heated 3.5 h. at 180°, give 3,3-diphenyl-1,4-dimethyl-2-pyrrolidone, m. 121-3°. Ph₂CHCN (67.2 g.), 22 g. Me₂N(CH₂)₂CN, and 6.8 g. NaNH₂ in 200 mL. C₆H₆ give 39 g. crude 3-dimethylamino-1,1-diphenylpropyl cyanide (V); HCl salt, m. 196-7°; HI salt, m. 221-3°. V (14 g.) gives 9 g. 5-dimethylamino-3,3-diphenyl-2-pentanone (HCl salt, m. 152-3°); EtMgBr gives 6-dimethylamino-4,4-diphenyl-3-hexanone (HCl salt, m. 171-2°); PrMgI gives 1-dimethylamino-3,3-diphenyl-4-heptanone (HI salt, m. 156-7°); iso-PrMgBr yields 6-dimethylamino-4,4-diphenyl-2-methyl-3-hexanone (HBr salt, m. 104-6°). 3-(1-Piperidyl)-1,1-diphenylpropyl cyanide (VI), m. 73-4° [HCl salt, m. 196-7°; HBr salt, m. 185-6°; HI salt, m. 152-3°; nitrate, m. 155° (decomposition)]. VI and MeMgI give 5-(1-piperidyl)-3,3-diphenyl-2-pentanone (HBr salt, m. 162-3°; HI salt, m. 158-9°); EtMgI yields 6-(1-piperidyl)-4,4-diphenyl-3-hexanone (HBr salt, m. 192-3°); PrMgI gives 1-(1-piperidyl)-3,3-diphenyl-4-heptanone (HCl salt, m. 158-60°; HI salt, m. 217-20°). VI and PhMgBr give Ph 3-(1-piperidyl)-1,1-diphenylpropyl ketone-HBr, m. 191-3°. VI (1.9 g.) and 3.6 mL. H₂SO₄, refluxed 30 min., give 0.5 g. α,α-diphenyl-1-piperidinebutyric acid, m. 230-5° (decomposition) (HCl salt, m. 236° (decomposition); H sulfate, m. 105-14°), and 0.6 g. of the amide, m. 178-9°; Me ester-HBr, with 2 mols. H₂O, m. 78-82°; Et ester-HBr, m. 194-6°. VI (2.3 g.), 0.9 g. NaNH₂, and 25 mL. C₆H₆, refluxed 3 h., give 3-(1-piperidyl)-1,1-diphenylpropane-HCl, m. 208-10°.

Journal of the Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C4H6O3, Product Details of C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shaykhutdinova, Polina published the artcileFurther Structural Modification of Sulfur-Stabilized Silicon Cations with Binaphthyl Backbones, Related Products of chlorides-buliding-blocks, the publication is Synthesis (2019), 51(10), 2221-2229, database is CAplus.

The synthesis and spectroscopic characterization of two novel cationic Si-S Lewis pairs with a chiral 4,4′-disubstituted binaphthyl silepine backbone are described. Both Lewis acids induce significant enantioselectivity in the model Diels-Alder reaction of cyclohexa-1,3-diene and chalcone but addnl. substitution of the binaphthyl backbone exerts a minimal effect on enantioinduction compared to previously reported Lewis acids. Another Si cation with a chiral spirocyclic backbone induces enantioselectivity in the same range but its synthesis is laborious.

Synthesis published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C40H35N7O8, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Florvall, Lennart published the artcilePotential neuroleptic agents. 2,6-Dialkoxybenzamide derivatives with potent dopamine receptor blocking activities, Category: chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (1982), 25(11), 1280-6, database is CAplus and MEDLINE.

Nineteen novel N-(2-pyrrolidinylmethyl)benzamides I (R = OMe, OEt, OCHMe₂, or Cl; R¹ and R² = H, Br, or Cl; R³ and R⁴ = H or Et) were synthesized and tested for dopamine receptor blockade in vivo by their ability to block the apomorphine syndrome in the rat. Several compounds were more potent than sulpiride as dopamine receptor blockers and displayed low liability to induce extrapyramidal side effects (catalepsy) in the rat. The blockade of dopamine receptor activity in vivo was mainly confined to the levorotatory isomers having the S absolute configuration. Structure-activity relationships are discussed.

Journal of Medicinal Chemistry published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C9H9ClO4, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics