Author: Jessica.F

Nagarajaiah, H. published the artcileSequential One-Pot Synthesis of 2-Aminothiazoles Using Corresponding Ketones: Insights into Their Structural Features, Safety of 1-(4-Chlorophenyl)thiourea, the publication is Polycyclic Aromatic Compounds (2022), 42(4), 1909-1919, database is CAplus.

2-Aminothiazoles have been synthesized by a one-pot, two-step sequential procedure in solution state which does not involve the isolation of intermediates. It involves α-halogenation of corresponding precursor ketones followed by condensation with substituted thiourea derivatives All the products were analyzed by IR, NMR, mass spectral techniques and four of them were evaluated crystallog. One of them crystallizes in the triclinic crystal system with space group P, while, all the other compounds crystallize in the monoclinic crystal system in two different space groups viz. P2₁/c and P2₁/n. The modified 2-aminothiazole core did not show any change in the intermol. interaction. The N-H… N interaction predominates over other interactions forming centrosym. head to head dimer with the neighboring atoms. This feature is observed in all the mols. except N-(4-(4-bromophenyl)-3-(2,5-dimethylphenyl)thiazol-2(3H)-ylidene)-2,5-dimethylaniline.

Polycyclic Aromatic Compounds published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Safety of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ramacharyulu, P. V. R. K. published the artcilePhotocatalytic decontamination of sulfur mustard using titania nanomaterials, Application of 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Molecular Catalysis A: Chemical (2012), 132-137, database is CAplus.

Photocatalytic decontamination of sulfur mustard (HD) was studied on titania nanomaterials, and data obtained with irradiation of sunlight and UV-A light were compared with that obtained without irradiation Role of particle size on photocatalytic decontamination of HD was also studied. Decontamination efficiency decreased when particle size was increased from 11 to 1000 nm. TiO₂ nanoparticles of ∼11 nm size of anatase phase exhibited superior decontamination properties relative to larger ones. 100% of HD was decontaminated on their surface within 6 h with irradiation of light. Without irradiation, only 24.7% of HD was removed. GC-MS data indicated decontamination of HD to acetaldehyde, CO₂, sulfur mustard sulfoxide, thiodiglycol, acetic acid, etc. due to photocatalysis. Without irradiation only hydrolysis products of HD like thiodiglycol were observed to be formed.

Journal of Molecular Catalysis A: Chemical published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Application of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kapoor, Jitander K. published the artcileSelective Synthesis of 3-(α,α-Dibromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one as an Excellent Precursor for the Synthesis of 2-Substituted 4-(4-Hydroxy-6-methyl-2H-2-oxopyran-3-yl)thiazoles as Antimicrobial and Antifungal Agents, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is Journal of Heterocyclic Chemistry (2018), 55(4), 899-906, database is CAplus.

A selective synthesis of 3-(α,α-dibromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one has been achieved by bromination of DHA using CuBr₂/CHCl₃-EtOAc. The reaction of the above compound with different thioureas/thiomides/thiosemicarbazide offers a convenient and efficient method for the syntheses of 2-substituted 4-(4-hydroxy-6-methyl-2H-2-oxopyran-3-yl)thiazoles I (R = C₆H₅NH, 4-MeC₆H₄NH, 4-ClC₆H₄NH, etc.). These thiazoles were evaluated for their antimicrobial and antifungal activity.

Journal of Heterocyclic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Alagiri, Kaliyamoorthy published the artcileCatalyst-Free Regio- and Stereospecific Synthesis of β-Sulfonamido Dithiocarbamates: Efficient Ring-Opening Reactions of N-Tosyl Aziridines by Dialkyldithiocarbamates, COA of Formula: C7H13ClNNaO5S, the publication is Chemistry – A European Journal (2011), 17(25), 6922-6925, S6922/1-S6922/62, database is CAplus and MEDLINE.

We have developed an efficient protocol for the synthesis of β-sulfonamido dithiocarbamates by using a ring-opening strategy of aziridines by thiocarbamates. These methods avoid toxic catalysts and, in most cases, give nearly quant. yields without any byproducts. This strategy provides an elegant method for synthesizing a wide range of β-sulfonamido dithiocarbamates by using inexpensive and readily available starting materials. In addition, a one-pot method has been developed for a facile ring-opening of aziridines by using in situ generated dialkyldithiocarbamate. This methodol. could potentially prove useful for the synthesis of medicinally active and other com. dithiocarbamate derivatives

Chemistry – A European Journal published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, COA of Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Olmstead, Marilyn M. published the artcileCrystal and molecular structure of chloramine-T trihydrate. Absence of a sodium-nitrogen interaction in the oxidant. N-chloro-N-sodiotoluene-p-sulfonamide, Product Details of C7H13ClNNaO5S, the publication is Inorganic Chemistry (1986), 25(22), 4057-8, database is CAplus.

The title compound is triclinic, space group PT, with a 6.393(1), b 7.510(1)8 c 13.767(2) Å, α 85.33(1), β 83.92(1), and γ 74.11(1)°; Z = 2. Final R = 0.039 for 2366 data. At. coordinates are given. The main feature of the structure involves the lack of the commonly represented interaction between Na and N. Instead, the Na ion is coordinated to one of the sulfonamide oxygens. The rest of the Na coordination sphere involves oxygens (from water of crystallization) and a Cl from a neighboring mol. The structure is the first for an [RSO₂NCl]^– moiety.

Inorganic Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Product Details of C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gaglione, Maria published the artcileTuning RNA Interference by Enhancing siRNA/PAZ Recognition, Quality Control of 33697-81-3, the publication is ACS Medicinal Chemistry Letters (2013), 4(1), 75-78, database is CAplus and MEDLINE.

Chem. modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence, and better serum resistance. Theor. data allowed us to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ.

ACS Medicinal Chemistry Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Davies, W. published the artcilePolymerization of thiophene derivatives. V. The self-condensation of 4,5- and 6,7-benzothianaphthene 1,1-dioxides. A new route to 1-(1-naphthyl)- and 4-(2-naphthyl)phenanthrene, Related Products of chlorides-buliding-blocks, the publication is Journal of the Chemical Society (1956), 2609-14, database is CAplus.

cf. C.A. 50, 1752d. 2-(1-Naphthyl)ethanol, b_0.2 130-2°, with PBr₃ gave 2-(1-naphthylethyl) bromide (I). I (98 g.) was refluxed and stirred 15 hrs. with 170 g. of Na₂SO₃.7H₂O to give 81 g. of Na 2-(1-naphthyl)ethanesulfonate (II). II stirred 30 min. with 66 g. PCl₅ at room temperature, the mixture warmed 30 min. on a steam bath and extracted with Et₂O, and the extract cooled precipitated gave 48 g. 2-(1-naphthyl)ethanesulfonyl chloride (III), m. 48-8.5°; anilide, m. 133.5-34°; amide, m. 172.5-73°. III (40 g.) in 75 ml. PhNO₂ was added to 24 g. powd. AlCl₃ in 200 ml. PhNO₂, the mixture kept 1 hr. at room temperature and 2 hrs. at 70°, the complex decomposed with dilute HCl, the solvent steam distilled, and the residue extracted with C₆H₆ gave 14.8 g. 2,3-dihydro-4,5-benzothianaphthene 1,1-dioxide (IV), m. 178-8.5°. IV (6.0 g.) refluxed 8 hrs. with 4.8 g. N-bromosuccinimide and 0.1 g. Bz₂O₂ in 150 ml. CCl₄, the solvent removed, and the residue dissolved in hot C₆H₆, filtered, and chromatographed on Al₂O₃ gave 2.7 g. 4,5-benzothianaphthene 1,1-dioxide (V), m. 136-7° or 141-2° with evolution of SO₂. V was reduced with LiAlH₄ to give 2,3-dihydrothianaphthene (VI), m. 86.5-87°. VI refluxed with chloranil in xylene 6 hrs. and the mixture cooled, filtered, diluted with C₆H₆, and chromatographed gave 4,5-benzothianaphthene. V (2.5 g.) in 50 ml. xylene was refluxed until evolution of SO₂ ceased. Evaporation gave 1.6 g. 10,11-dihydro-9-thia-5,6-benzonaphtho(1′,2′,3,4)fluorene 9,9-dioxide (VII), m. 226°. VII refluxed 10 min. in 50% aqueous KOH in (HOCH₂CH₂)₂O and the mixture diluted with H₂O and extracted with Et₂O gave 1-(1-naphthyl)phenanthrene, m. and mixed m.p. 115-16°. By the same sequence of reactions, the following compounds were prepared from 2-(2-naphthyl)ethanol, m. 66°: Na 2-(2-naphthyl)ethanesulfonate; 2,2′-naphthylethanesulfonyl chloride, m. 66-6.5° (amide, m. 200-200.5°); 2,3-dihydro-6,7-benzothianaphthene 1,1-dioxide, m. 187.5-88°; 6,7-benzothianaphthene 1,1-dioxide, m. 181-2°or 194-5° (decomposition); 10,11-dihydro-9-thia-7,8-benzonaphtho(2′,1′-3,4)fluorene 9,9-dioxide, m. 166-7°; and 4-(2-naphthyl)phenanthrene, m. 105-6°. 6-Tetralinsulfonyl chloride, m. 57-8°, was reduced with Zn and H₂SO₄ to 6-mercaptotetralin (VIII), b₃₅ 161-2°. VIII added to still-reacting Na in EtOH, followed by chloroacetal and NaBr, the mixture refluxed 6 hrs., the solution extracted with 2% aqueous NaOH, then Et₂O, the Et₂O extract distilled gave (6-tetralylthio)acetaldehyde di-Et acetal (IX), b_0.5 160-1°. Slow addition of IX to mixed P₂O₅ and H₃PO₄ gave a yellow oil which was distilled to give a mixture of tetrahydrobenzothianaphthenes, b_0.3 119-21°. Tetralin (50 g.) stirred 1 hr. into ClSO₃H at -5° warmed to room temperature, the mixture precipitated with ice and extraction with CCl₄, and the extract evaporated gave a mixture of 68 g. of 5- and 6-tetralinsulfonyl chlorides; this product (20 g.) added to 14.5 g. ClCH₂CO₂H on 12 g. NaOH in 250 ml. H₂O and the mixture heated 1 hr. on a water bath, cooled, and acidified precipitated 25 g. of an acid mixture (X). X (20 g.) in 80 ml. 5% KOH was added to 40 ml. 40% KOH. The acidified precipitate gave 9.2 g. (6-tetralylthio)acetic acid, m. 78.5-79. Acidification of the filtrate gave 9.0 g. of (5-tetralylthio)acetic acid, m. 133-4°.

Journal of the Chemical Society published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Doobary, Sayad published the artcileIntramolecular Alkene Fluoroarylation of Phenolic Ethers enabled by Electrochemically Generated Iodane, COA of Formula: C8H7ClO3, the publication is Journal of Organic Chemistry (2021), 86(22), 16095-16103, database is CAplus and MEDLINE.

Herein, synthesis of 3-fluorinated chromanes from allylic phenol ethers was described. Oxidant-free approach takes advantage of an electrochem. generation of a hypervalent iodine species, difluoro-λ³-tolyl iodane, which mediates the alkene fluoroarylation. High yields and selectivity for this transformation are achieved for electron poor substrates. The redox chem. has been characterized for the electrochem. generation of the iodane in the presence of fluoride, and insights into the mechanism are given. The transformation has been demonstrated on larger gram scales, which represents the potential broader utility of the process.

Journal of Organic Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nongmaithem, Sapana published the artcileEnhanced Polar Auxin Transport in Tomato Polycotyledon Mutant Seems to be Related to Glutathione Levels, Safety of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Journal of Plant Growth Regulation (2021), 40(2), 761-773, database is CAplus.

Glutathione-dependent root growth in Arabidopsis is linked to polar auxin transport (PAT). Arabidopsis mutants with reduced glutathione (GSH) levels also show reduced PAT. To gain an insight into the relationship between PAT and GSH level, we analyzed tomato polycotyledon mutant, pct1-2, which has enhanced PAT. Microarray anal. of gene expression in pct1-2 mutant revealed underexpression of several genes related to glutamate and glutathione metabolism In consonance with microarray anal., enzymic as well as in vivo assay revealed higher glutathione levels in the early phase of pct1-2 seedling growth than WT. The inhibition of auxin transport by 2,3,5-triiodobenzoic acid (TIBA) reduced both GSH level and PIN1 expression in pct1-2 root tips. The reduction of in vivo GSH accumulation in pct1-2 root tips by buthionine sulfoximine (BSO) stimulated elongation of the short root of pct1-2 mutant akin to TIBA. The rescue of the short root phenotype of the pct1-2 mutant was restricted to TIBA and BSO. The other auxin transport inhibitors 1-N-naphthylphthalamic acid (NPA), 2-[4-(diethylamino)-2-hydroxybenzoyl] benzoic acid (BUM), 3-chloro-4-hydroxyphenylacetic acid (CHPAA), brefeldin and gravacin inhibited root elongation in both WT and pct1-2 mutant. Our results indicate a relationship between PAT and GSH levels in tomato akin to Arabidopsis. Our work also highlights that TIBA rescues the short root phenotype of the pct1-2 mutant by acting on a PAT component distinct from the site of action of other PAT inhibitors.

Journal of Plant Growth Regulation published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Safety of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Belyakova, Z. V. published the artcileEffect of catalysts on the reaction of allyl esters with hydrosilanes, Name: Dichloro(methyl)(octyl)silane, the publication is Russian Journal of General Chemistry (2010), 80(4), 728-733, database is CAplus.

Hydrosilylation of allyl esters XOCH₂CH:CH₂ (X = MeCO, CF₃CO, C₃F₇CO, CH₂:C(Me)CO), PhOCH₂CH:CH₂ and ClCH₂CH:CH₂ with hydrosilanes HSiCl₃, HSi(OEt)₃ and HSiMeCl₂ in the presence of Speier’s catalyst, Speier’s catalyst with additives, and of various Ni compounds was studied. The catalytic hydrosilylation reaction in the presence of the Speier catalyst is accompanied by reductions Additives to the Speier catalyst (vinyltriethoxysilane, allyl acetate and trifluoroacetate) suppress the reduction reaction considerably. E.g., hydrosilylation of allyl methacrylate with HSiCl₃ in the presence of Speier’s catalyst gave CH₂:C(Me)CO₂CH₂CH₂CH₂SiCl₃ in 67% yield and a ratio of 5.55 of the addition product to the reduction product. The same reaction in the presence of Speier’s catalyst and vinyltriethoxysilane afforded CH₂:C(Me)CO₂CH₂CH₂CH₂SiCl₃ in 87% yield and a ratio of 114.1 of the addition product to the reduction product. In the presence of the studied Ni compounds mainly reduction and isomerization reactions of allyl Ph ether occurred. The best Ni catalysts for hydrosilylation were mixtures of NiCl₂ or Ni(acac)₂ with phosphine oxides. In contrast to allyl Ph ether, the hydrosilylation of simple olefins proceeds easier. E.g., hydrosilylation of 1-heptene with HSiCl₃ in the presence of NiCl₂ and (octyl)₃P:O gives the hydrosilylation product trichloroheptylsilane in 94% yield in the reaction mixture

Russian Journal of General Chemistry published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Name: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics