Author: Jessica.F

Karrenbrock, Friedhelm published the artcileCathodic formation of olefins from phosphonates, COA of Formula: C5H10Cl3O3P, the publication is Tetrahedron Letters (1979), 2915-16, database is CAplus.

Cathodic reduction of Cl₃CP(O)(OEt)₂ in the presence of RR¹CO [R = 4-MeOC₆H₄, CH₂:CMe, Me(CH₂)₄, R¹ = H; R = Et, R¹ = Me; R = R¹ = Bu; RR¹ = (CH₂)₄] gave 24-52% RCR¹:CCl₂. Similar reduction of (EtO)₂P(O)CCl₂CO₂Et in the presence of PhCHO or cyclohexanone gave 55% of a 40:60 mixture of E– and Z-PhCH:CClCO₂Et and 43% Et chlorocyclohexylideneacetate, resp.

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, COA of Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Teulade, Marie Paule published the artcileα-Lithiated O,O-diethyl [chloro(trimethylsilyl)methyl]phosphonate. I. Preparation and properties, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Journal of Organometallic Chemistry (1988), 338(3), 295-303, database is CAplus.

Silylation of either (EtO)₂P(O)CH₂Cl or (EtO)₂P(O)CCl₃ in the presence of excess BuLi leads to the quant. generation of (EtO)₂P(O)CClLiSiMe₃. This stable type of anion can be protonated, deuterated, or alkylated. Compounds thus obtained can be desilylated in basic medium, or used for the preparation of α-bromo and α-iodo phosphonates after halogen-metal exchange. E.g., treating (EtO)₂P(O)CRClSiMe₃ (R = Me, Et, Pr, allyl) with BuLi, then 1,2-diiodoethane or 1,2-dibromoethane gave (EtO)₂P(O)CRXSiMe₃ (X = iodo, Br, resp.). Condensation with aliphatic and aromatic aldehydes gives vinylphosphonates without stereochem. control.

Journal of Organometallic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C9H9BrO2, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Diziere, Rachel published the artcileA new simple method for the synthesis of 1-alkynylphosphonates using (EtO)₂P(O)CCl₃ as precursor, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Tetrahedron Letters (1996), 37(11), 1863-6, database is CAplus.

1-Alkynylphosphonates, (EtO)₂P(O)CCR (R = Ph, 4-Me₂NC₆H₄, 2-pyridyl, 2-thienyl, etc.), were obtained from (EtO)₂P(O)CCl₃ and aldehydes in a 1-pot procedure. It involves the formation of α-chlorovinyl phosphonate intermediates (E- and Z-isomers), (EtO)₂P(O)CHCl:CHR, by a Peterson olefination reaction followed by dehydrochlorination with LiHMDS.

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Savelyev, Yuri V. published the artcileNovel polyurethane foams with biological activity and based composites, Formula: C38H74Cl2N2O4, the publication is Rigas Tehniskas Universitates Zinatniskie Raksti, Serija 1: Materialzinatne un Lietiska Kimija (2007), 107-114, database is CAplus.

New polyurethane foams with different formulations were synthesized. Created polyurethane foams are characterized by fungicidal activity against mold and yeast-like fungi of the genera: Aspergillis, Chaetomium, Penicillium, Trichoderma, and Candida and bactericidal activity in regards to some pathogenic bacteria: Staphylococcus aureus, E. coli, Klebsiella pneumoniae, Proteus. Polyurethane foams are characterized by the compatibility with organism tissues – fast germination of the tissues through the polyurethane foam samples from 1 up to 3 mo and practically absence of the united-tissued capsule and cell’s reaction. The polyurethane foam was used as supporting matrixes of granular solid adsorbents. The parameters of porous frame (pore volume on benzene W_s and sp. surface area S_BET) of the polyurethane foam-activated carbon sorbic composite systems at optimum ratios differ a little from the same indexes of virgin carbon and have practically identical tendency to change. These samples are possessed stability for fungi attack.

Rigas Tehniskas Universitates Zinatniskie Raksti, Serija 1: Materialzinatne un Lietiska Kimija published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Villemin, Didier published the artcileAddition of diethyl trichloromethylphosphonate to olefins catalyzed by copper complexes, SDS of cas: 866-23-9, the publication is Tetrahedron Letters (1994), 35(21), 3537-8, database is CAplus.

R¹R²CClCH₂CCl₂P(O)(OEt)₂ (e.g., R¹ = CO₂Et, R² = H) were prepared in 31-65% yields by treating R¹R²C:CH₂ with Cl₃CP(O)(OEt)₂ catalyzed by Cu amine complexes.

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C7H8BFO2, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Milani, Amir H. published the artcileLight-Triggered Programming of Hydrogel Properties Using Sleeping Photoactive Polymer Nanoparticles, Application of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, the publication is Chemistry of Materials (2021), 33(7), 2319-2330, database is CAplus.

A key characteristic of programmable hydrogels is that their phys. and chem. properties can be changed postsynthetically. In order to achieve this, we used sub-50 nm photoacid/base generator nanoparticles, which could alter the charge d./polarity of a host macroscopic hydrogel (e.g., polyacrylamide). The photoacid generator (PAG) nanoparticles, were composed of poly(Me methacrylate-co-4,5-dimethoxy-2-nitrobenzyl methacrylate-co-1,6-hexanediol diacrylate) and exhibited a pH-dependent swelling behavior when they were irradiated with UV light. Thus, using PAG nanoparticles enabled space-selective light-triggered swelling of host hydrogels by increasing the charge d. at alk. pH. Using photobase generator (PBG) nanoparticles, consisting of poly(Me methacrylate-co-2-nitrobenzyl Me 4-methacryloyloxy piperidine-1-carboxylate-co-1,6-hexanediol diacrylate), it was possible to space-selectively produce pos. charge, at acidic pH, within the host hydrogel network. PBG nanoparticles added several functionalities to the host hydrogel, including reversible writing/erasing patterns as well as postpolymn. in desired sites. Including mixtures of PAG and PBG nanoparticles caused deswelling of the host hydrogel upon UV-irradiation By increasing the mass fraction of PAG/PBG nanoparticles within the hydrogel, the deswelling effect was limited only to the top surface area, resulting in a monolayer actuator with a large bending angle. This study has successfully demonstrated the excellent potential of using PAG/PBG nanoparticles to confer photoresponsive behaviors that transform nonresponsive hydrogels into responsive hydrogels on demand. This system could be spatially tailored to provide a wide range of useful properties such as initiation sites for synthesis, writing/erasing, and actuation.

Chemistry of Materials published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Application of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kato, Naoya published the artcileSynthesis and evaluation of a novel adapter lipid derivative for preparation of cyclic peptide-modified PEGylated liposomes: Application of cyclic RGD peptide, Formula: C19H14Cl2, the publication is European Journal of Pharmaceutical Sciences (2022), 106239, database is CAplus and MEDLINE.

Peptide ligand modified nanoparticles can simply prepared by post-insertion method to mix pre-formed nanoparticles with peptide-lipid conjugates in an aqueous solution at an optimal temperature Therefore, water dispersibility of peptide-lipid conjugates is a very important factor for implementing the post-insertion method. We proposed that highly water dispersible peptide-lipid conjugates can be easily synthesized by sep. designing novel adapter lipids with different water dispersibility and reacting them with ligands in a highly efficient manner. Adapter lipids have three critical roles; as spacers of ligand-conjugated lipids for efficient ligand presentation, as structures that form discrete mol. weight distributions, and as providing water dispersibility. In this study, we developed a novel adapter-lipid derivative that enables a variety of cyclic peptide modifications using the click reaction. The integrin αvβ3-targeted cyclic RGDfK (cRGD) peptide was selected as the cyclic peptide ligand. We designed a novel alkyne-tagged lipid with a discrete peptide spacer and bound the cRGD peptide using a click reaction to synthesize a cRGD-conjugated lipid with good water dispersibility for the preparation of cRGD-modified PEGylated liposomes using the post-insertion method. We also revealed that cRGD-modified PEGylated liposomes are efficiently associated with integrin αvβ3-expressing murine colon carcinoma (Colon-26) cells in a modification amount- and peptide sequence-dependent manner, showing high cytotoxicity upon loading with doxorubicin. This novel adapter lipid derivative can be used to synthesize various cyclic peptides by click reactions and will provide useful insights for the future development of cyclic peptide-modified PEGylated liposomes.

European Journal of Pharmaceutical Sciences published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Honda, Mitsunori published the artcileSynthesis of 1-hydrocarbon substituted cyclopropyl silyl ketones, Safety of trimethyloxosulphonium chloride, the publication is Tetrahedron Letters (2018), 59(42), 3777-3781, database is CAplus.

The synthesis of cyclopropyl silyl ketones possessing a hydrocarbon group at 1-position of three-membered ring was investigated. The reaction of sulfoxonium ylide with α,β-unsaturated acylsilanes derived from α,β-unsaturated aldehydes did not afford the desired acylsilane derivatives Instead, the corresponding silyl enol ethers were yielded exclusively. On the other hand, the Corey-Chaykovsky cyclopropanation of α-substituted α,β-unsaturated aldehydes proceeded well to give 1-substituted cyclopropyl aldehydes. The silyl substitution of formyl proton in the obtained aldehydes via umpolung of carbonyl group afforded the target acylsilanes.

Tetrahedron Letters published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Safety of trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Le Menn, Jean Christophe published the artcileElectrochemically generated phosphonate carbanions: formation and reactivity towards aldehydes, Application of Diethyltrichloromethylphosphonate, the publication is Canadian Journal of Chemistry (1989), 67(8), 1332-43, database is CAplus.

Reactivity towards p-methoxybenzaldehyde (ArCHO) of electrochem. generated phosphonate carbanions was investigated. Electrolysis were carried out at a Hg cathode in DMF and two routes to the desired carbanion were compared: (i) deprotonation of phosphonates of general formula (EtO)₂P(O)CHYW (Y = W = Cl; Y = H, W = Cl; Y = Cl, W = CO₂Et; Y = H, W = CO₂Et; Y = CH₃, W = CO₂Et; Y = Cl, W = CH₃), by the bases resulting from the electroreduction of azobenzene; addition of the carbanion formed onto the carbonyl group takes place and leads to the adduct (EtO)₂P(O)CYW(Ar)O^–. (Ii) Two-electron reduction of halophosphonates (EtO)₂P(O)CXYZ (X = Cl, Y and W as above; X = Br, W = CO₂Et, Y = Cl, Br, or CH₃); when no H atoms is present on the carbon bearing the phosphonate group (Y and W ≠ H), the same evolution leading to the above adduct is observed; on the contrary, when Y = H, the electrogenerated carbanion deprotonates the substrate and the resulting carbanion (EtO)₂P(O)CXW^– reacts with the aldehyde, giving the adduct (EtO)₂P(O)CXW(Ar)O^–. Evolution of the intermediate adduct depends on the substituents Y (or X) and W: when W = CO₂Et, whatever the nature of Y (or X), di-Et phosphate is eliminated with formation of the ethylenic ArCH = CWY (or X) (Wittig-Horner reaction); the same evolution is observed when Y = W = Cl. When W = Cl and Y = H or CH₃, the final product is the phosphonate epoxide resulting from chloride elimination (Darzens reaction). Chemo- and stereoselectivity depends only on the nature of Y and W but are independent of the mode of generation of the carbanion. Yields are limited by side-protonation reactions, which are related to the basicity of the phosphonate carbanions. Anal. of the results permits selection of the optimal electrolysis conditions for purposes of synthesis.

Canadian Journal of Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Le Menn, J. Christophe published the artcileElectrochemical synthesis of diethyl 1,1-dichloroalkylphosphonates, Related Products of chlorides-buliding-blocks, the publication is Journal of Chemical Research, Synopses (1989), 26-7, database is CAplus.

The electrochem. reduction of diethyl(trichloromethyl)phosphonate in aprotic medium containing alkyl halides forms diethyl-1,1-dichloroalkylphosphonates in good yields. Thus, in a 2-compartment cell a mixture of trichloromethylphosphonate and alkylating agent in DMF containing Bu₄NBF₄ was electrolyzed using a Hg pool cathode. The product was isolated and distilled under reduced pressure.

Journal of Chemical Research, Synopses published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics