Author: Jessica.F

Zhang, Xiao published the artcileDesign, Synthesis, and Synergistic Activity of Eight-Membered Oxabridge Neonicotinoid Analogues, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Journal of Agricultural and Food Chemistry (2021), 69(10), 3005-3014, database is CAplus and MEDLINE.

Insecticide synergists are sought-after due to their potential in improving the pesticide control efficacy with a reduced dose of an active ingredient. We previously reported that a cis-configuration neonicotinoid (IPPA08) exhibited specific synergistic activity toward neonicotinoid insecticides. In this study, we synthesized a series of structural analogs of IPPA08 by converting the pyridyl moiety of IPPA08 into Ph groups, via facile double-Mannich condensation reactions between nitromethylene compounds and glutaraldehyde. All of the oxabridged neonicotinoid compounds were found to increase the toxicity of imidacloprid against Aphis craccivora. Notably, compound (I) at 0.75 mg/L lowered the LC₅₀ value of imidacloprid against A. craccivora by 6.54-fold, while a 3.50-fold reduction of the LC₅₀ value was observed for IPPA08. The results of bee toxicity test showed that compound I display selectivity in its effects on imidacloprid toxicity against the honey bee (Apis mellifera L.). In summary, replacing the pyridyl ring with a Ph ring was a viable approach to obtain a novel synergist with oxabridged moiety for neonicotinoid insecticides.

Journal of Agricultural and Food Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H17Br, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Xiao published the artcileDesign, Synthesis, and Synergistic Activity of Eight-Membered Oxabridge Neonicotinoid Analogues, Category: chlorides-buliding-blocks, the publication is Journal of Agricultural and Food Chemistry (2021), 69(10), 3005-3014, database is CAplus and MEDLINE.

Insecticide synergists are sought-after due to their potential in improving the pesticide control efficacy with a reduced dose of an active ingredient. We previously reported that a cis-configuration neonicotinoid (IPPA08) exhibited specific synergistic activity toward neonicotinoid insecticides. In this study, we synthesized a series of structural analogs of IPPA08 by converting the pyridyl moiety of IPPA08 into Ph groups, via facile double-Mannich condensation reactions between nitromethylene compounds and glutaraldehyde. All of the oxabridged neonicotinoid compounds were found to increase the toxicity of imidacloprid against Aphis craccivora. Notably, compound (I) at 0.75 mg/L lowered the LC₅₀ value of imidacloprid against A. craccivora by 6.54-fold, while a 3.50-fold reduction of the LC₅₀ value was observed for IPPA08. The results of bee toxicity test showed that compound I display selectivity in its effects on imidacloprid toxicity against the honey bee (Apis mellifera L.). In summary, replacing the pyridyl ring with a Ph ring was a viable approach to obtain a novel synergist with oxabridged moiety for neonicotinoid insecticides.

Journal of Agricultural and Food Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C11H13N3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

He, Renbao published the artcileSynthesis of 2,4,5-trifluorobenacetic acid, Quality Control of 243139-71-1, the publication is Huagong Shengchan Yu Jishu (2011), 18(3), 4-6, database is CAplus.

The compound 2,4,5-trifluorobenzeneacetic acid was synthesized from 1,2,4-trifluorobenzene via chloromethylation, carbonylation and hydrolyzation. Results showed that the optimization synthesis condition of 2,4,5-trifluorobenzyl chloride were as follows: m (C₆H₃F₃):m (paraformaldehyde)=1.0:0.875-0.865, reaction time 10 h. And the optimization synthesis condition of 2,4,5-trifluorobenzeneacetic acid was m (C₇H₄F₃Cl): m (cat)=1:0.275-0.25 and the reaction temperature was 40°C, under this condition, the total yield was above 60%, the purity was above 99%. The proportion of reactants and dosage of catalyst were discussed.

Huagong Shengchan Yu Jishu published new progress about 243139-71-1. 243139-71-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 2,4,5-Trifluorobenzyl chloride, and the molecular formula is C7H4ClF3, Quality Control of 243139-71-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jiwen published the artcileOptimization of GPR40 Agonists for Type 2 Diabetes, Recommanded Product: 4-Chloro-2-methylphenylboronic acid, the publication is ACS Medicinal Chemistry Letters (2014), 5(5), 517-521, database is CAplus and MEDLINE.

GPR40 (FFA1 and FFAR1) has gained significant interest as a target for the treatment of type 2 diabetes. TAK-875 (1), a GPR40 agonist, lowered Hb A1c (HbA1c) and lowered both postprandial and fasting blood glucose levels in type 2 diabetic patients in phase II clin. trials. We optimized phenylpropanoic acid derivatives as GPR40 agonists and identified AMG 837 (2) as a clin. candidate. Here we report our efforts in searching for structurally distinct back-ups for AMG 837. These efforts led to the identification of more polar GPR40 agonists, such as AM-4668 (10), that have improved potency, excellent pharmacokinetic properties across species, and min. central nervous system (CNS) penetration.

ACS Medicinal Chemistry Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Recommanded Product: 4-Chloro-2-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Xuemin published the artcileQuantitative analysis of 2,3-dibromopropionyl chloride, Application of 2,3-Dibromopropionylchloride, the publication is Ranliao Yu Ranse (2011), 48(6), 56-59, database is CAplus.

An anal. method for a dye intermediate 2,3-dibromopropionyl chloride was established. The method was based on derivation of 2,3-dibromopropionyl chloride. 2,3-Dibromo-N-phenylpropanamide was almost quant. prepared from 2,3-dibromopropionyl chloride and aniline by amidation. The external standard calibration curve of 2,3-dibromo-N-phenylpropanamide was obtained by HPLC, thus the content of 2,3-dibromopropionyl chloride was determined The linear regression equation of the method was given, the liner correlation coefficient was 0.9997, the linear range was 0.1341-0.6707 mg/mL, the standard deviation was 0.005, the variation coefficient was 0.5%, and the recovery rate was 99.81%-100.05%.

Ranliao Yu Ranse published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Application of 2,3-Dibromopropionylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ziyong published the artcileSolvent-dependent and visible light-activated NIR photochromic dithienylethene modified by difluoroboron β-diketonates as fluorescent turn-on pH sensor, Related Products of chlorides-buliding-blocks, the publication is Dyes and Pigments (2019), 339-347, database is CAplus.

The development of near-IR (NIR) photochromic materials, particularly activated by visible light, are of increasing interest for their potential application in photoresponsive optoelectronics and functional bio-materials. Here, a novel D-DTE-A type dithienylethene NDB, which was modified by difluoroboron β-diketonate (BF₂bdk) and dimethylphenylamine (DMPA) moieties, has been developed. It exhibited solvent-dependent photophys. properties before irradiation, and the visible light-triggered NIR photochromic behavior with solvent-dependent features was only observed in Toluene. Moreover, it displayed intense fluorescent turn-on acid-sensing properties in less polar solvent [Toluene, Dichloromethane (DCM) and Et acetate (EA)] through the blockage of photoinduced electron transfer (PET) effect. Specially, NDB with photochromic inactivity in DCM could perform a unique gated photochromism in the presence of TFA/TEA.

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ziyong published the artcileSynthesis and properties of dithienylethene-functionalized switchable antibacterial agents, Formula: C15H14Cl2S2, the publication is Organic & Biomolecular Chemistry (2018), 16(38), 6988-6997, database is CAplus and MEDLINE.

Photopharmacol. involving azobenzene has offered a viable alternative for combating bacterial resistance. However, the degradation and potential toxicity of azobenzene limit its further study in vivo. Therefore, searching for an appropriate photoswitch for further clin. application is highly desirable. Herein a series of dithienylethene-functionalized switchable antibacterial agents have been designed and prepared by the introduction of the dithienylethene scaffold into fluoroquinolones. And it was found that these switchable antibacterial agents displayed good photochromism and fluorescence switching behaviors upon irradiation with UV/Vis light in DMSO. Surprisingly, methoxy-substituted dithienylethenes 3a and 3b exhibited fluorescence turn-on behavior. Furthermore, it was found that all of the open-isomers showed partial antibacterial activity on E. coli and S. aureus compared with the native drugs. Apart from 2a and 2b, the other switchable antibacterial agents showed a large difference in antibacterial activity on Gram-neg. E. coli between the open and closed forms, in which the antimicrobial activity of the ring-closed isomers for 1b and 3b was 16 times that of the corresponding ring-open isomers. DFT calculations showed that the ring-closed isomers of 1b and 3b presented a rigid “S-type” conformation, which may be conducive to forming more stable complexes with the DNA gyrase of E. coli.

Organic & Biomolecular Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Formula: C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Yang published the artcileStudy on the toxicity of organic pollutants to seven aquatic organisms based on Abraham model, Recommanded Product: 3-Chloro-4-fluoronitrobenzene, the publication is Huanjing Huaxue (2015), 34(1), 23-36, database is CAplus.

The toxicities of 141 organic pollutants to seven aquatic organisms (Vibrio fischeri, River bacteria, Scenedesmus obliquus, Daphnia magna, Cyprinuscarpio, Pimephalespromelas, Poeciliareticulata) were analyzed. A linear relationship between the toxicity data of non-polar or polar narcotics and hydrophobicity (lgK_ow) was established for the seven species, resp. This relationship was interpreted based on the theor. consideration. Meanwhile, quant. structure-activity relationship (QSAR) studies were performed between the toxicities of seven aquatic organisms and Abraham descriptors. The mechanisms of action to seven species were analyzed theor. based on Abraham descriptors and model coefficients The principal component anal. carried out on the regression coefficients of Abraham models showed that there were interspecies similarities and differences between the species. In the same time, the interspecies correlation of organic pollutants to seven aquatic organisms was analyzed. The results showed that there were good interspecies corrections between fish species, marine bacterium and fish or daphnia magna and fish. It suggested that some compounds shared the same toxic mechanism of action between the species. However, poor interspecies relationships found between toxicities to algae and daphnia magna or fish suggested that compounds have different toxic mechanism of action between these species.

Huanjing Huaxue published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C17H16O2, Recommanded Product: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Lijuan published the artcileDesign, synthesis, antiviral bioactivities and interaction mechanisms of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold, Computed Properties of 620-20-2, the publication is BMC Chemistry (2019), 13(1), 1-12, database is CAplus and MEDLINE.

penta-1,4-diene-3-one oxime ether and quinazolin-4(3H)-one derivatives possess favorable agricultural activities. Aiming to discover novel mols. with highly-efficient agricultural activities, a series of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold were synthesized and evaluated for their antiviral activities. Antiviral bioassays indicated that some title compounds exhibited significant antiviral activity against tobacco mosaic virus (TMV). In particular, compounds 8c, 8j and 8k possessed appreciable curative activities against TMV in vivo, with half-maximal effective concentration (EC50) values of 138.5, 132.9 and 125.6 μg/mL, resp., which are better than that of ningnanmycin (207.3 μg/mL). Furthermore, the microscale thermophoresis experiments (MST) on the interaction of compound 8k with TMV coat protein (TMV CP) showed 8k bound to TMV CP with a dissociation constant of 0.97 mmol/L. Docking studies provided further insights into the interaction of 8k with the Arg90 of TMV CP. Sixteen penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold were designed, synthesized, and their antiviral activities against TMV were evaluated. Antiviral bioassays indicated that some target compounds exhibited remarkable antiviral activities against TMV. Furthermore, through the MST and docking studies, we can speculate that 8k inhibited the virulence of TMV by binding Arg90 in TMV CP. These results indicated that this kind of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold could be further studied as potential alternative templates in the search for novel antiviral agents.

BMC Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Yu-Xi published the artcileCopper-Catalyzed Synthesis of O/N-Alkyl S-Phenyl Phenylcarbamothioates: An Odorless and Chemo-selective Chan-Lam Reaction to Construct C-S Bond, Name: 2-Chloro-4-methylphenylboronic acid, the publication is European Journal of Organic Chemistry (2022), 2022(32), e202200707, database is CAplus.

The O/N-alkyl-S-phenyl-(Z)-phenylcarbamothioates I [R¹ = H, 4-Me, 4-Cl, etc.; R² = OMe, OEt, OBu, N-morpholinyl; R³ = H, 3-Br, 4-Ph, etc.] were synthesized via copper-catalyzed chemoselective Chan-Lam reaction of odorless O/N-alkyl phenylthiocarbamates as sulfur sources and com. available phenylboronic acids as substrates. This methodol. featured simple performance, odorless sulfur source, easily available starting material, good functional group tolerance, and high chemo-selectivity to construct C-S bonds, thereby provided an alternative way to the synthesis of potentially bioactive compounds

European Journal of Organic Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H3IN2O2, Name: 2-Chloro-4-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics