Author: Jessica.F

Dong, Xiao-Yang published the artcileCopper-Catalyzed Asymmetric Coupling of Allenyl Radicals with Terminal Alkynes to Access Tetrasubstituted Allenes, Computed Properties of 866-23-9, the publication is Angewandte Chemie, International Edition (2021), 60(4), 2160-2164, database is CAplus and MEDLINE.

In contrast to the wealth of asym. transformations for generating central chirality from alkyl radicals, the enantiocontrol over the allenyl radicals for forging axial chirality represents an uncharted domain. The challenge arises from the unique elongated linear configuration of the allenyl radicals that necessitates the stereo-differentiation of remote motifs away from the radical reaction site. We herein describe a copper-catalyzed asym. radical 1,4-carboalkynylation of 1,3-enynes via the coupling of allenyl radicals with terminal alkynes, providing diverse synthetically challenging tetrasubstituted chiral allenes. A chiral N,N,P-ligand is crucial for both the reaction initiation and the enantiocontrol over the highly reactive allenyl radicals. The reaction features a broad substrate scope, covering a variety of (hetero)aryl and alkyl alkynes and 1,3-enynes as well as radical precursors with excellent functional group tolerance.

Angewandte Chemie, International Edition published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Computed Properties of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Wei published the artcileSynthesis and biological activity of novel 1,3,4-oxadiazole derivatives containing a pyrazole moiety, HPLC of Formula: 620-20-2, the publication is Research on Chemical Intermediates (2019), 45(12), 5989-6001, database is CAplus.

Several new 1,3,4-oxadiazole derivatives containing a pyrazole ring I (R = cyano, 3,4-dichlorophenyl, 2-chlorothiazol-5-yl, etc.) were designed and synthesized from Et acetoacetate and tri-Et orthoformate as starting materials via multi-step reactions. They were evaluated for fungicidal and herbicidal activities. Four of the compounds exhibited moderate fungicidal activity against Colletotrichum species. Most of the compounds had moderate-to-good activity as a herbicide.

Research on Chemical Intermediates published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C8H8O2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Surnin, V. A. published the artcileAminoalkylation of hydrazine by 2-halopropylamine hydrohalides, SDS of cas: 4584-49-0, the publication is Zhurnal Organicheskoi Khimii (1983), 19(11), 2288-94, database is CAplus.

MeCHXCH₂NRR¹.HX¹ (I; X = OH; R = H, R¹ = H, Me, Me₃C, Ph; R = R¹ = Me; X¹ = Br) reacted with PBr₃ or SOCl₂ to give 6 corresponding I (X = X¹ = Br, Cl) (II) in 31-90% yield. II reacted with N₂H₄.H₂O in MeOH to give mixtures of 5 corresponding H₂NNHCHMeCH₂NRR¹ (III) and RR¹NCHMeCH₂NHNH₂ (IV) with the latter predominating, indicating an aziridinium salt intermediate. All 10 III and IV condensed with 1 equivalent Me₂CO in C₆H₆ to give the corresponding Me₂C:NNHCHMeCH₂NRR¹ and RR¹NCHMeCH₂NHN:CMe₂, resp. Treating III (R = R¹ = H) and IV (R = R¹ = H) with excess refluxing Me₂CO containing potash gave 40% iminoimidazolidines V (Z = CHMeCH₂, CH₂CHMe).

Zhurnal Organicheskoi Khimii published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H10Cl3O3P, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cao, Chaotun published the artcileA new insight into the push-pull effect of substituents via the stilbene-like model compounds, Formula: C8H6ClF3, the publication is Journal of Physical Organic Chemistry (2022), 35(4), e4319, database is CAplus.

In this paper, authors report on 1-pyridyl-2-arylethenes, 1-furyl-2-arylethylenes, 1,2-diphenylpropylenes and substituted cinnamyl anilines as stilbene-like model compounds to investigate the factors dominating the push-pull effect of substituents via using the NMR chem. shift of bridging bond carbon atoms. It is demonstrated that the maximum push-pull effect is not always between the strong electron-donating D and strong electron-accepting A groups in D-π-A compounds The action mode of push-pull effect of substituents in D-π-A compounds is dominated by their mol. parent structure. The contribution of field/inductive effect and conjugative effect of a group to the push-pull effect is unequal. When the D-π-A parent mol. is in a plane, the influence of field/inductive effect of a group on the push-pull effect is greater than or close to that of its conjugative effect does. Although the parent mol. is sterically twisted, the push-pull effect is mainly dependent on the conjugative effect of a group. The results of this paper can provide us a new insight into the push-pull effect of substituents.

Journal of Physical Organic Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cao, Chaotun published the artcileA new insight into the push-pull effect of substituents via the stilbene-like model compounds, HPLC of Formula: 620-20-2, the publication is Journal of Physical Organic Chemistry (2022), 35(4), e4319, database is CAplus.

In this paper, authors report on 1-pyridyl-2-arylethenes, 1-furyl-2-arylethylenes, 1,2-diphenylpropylenes and substituted cinnamyl anilines as stilbene-like model compounds to investigate the factors dominating the push-pull effect of substituents via using the NMR chem. shift of bridging bond carbon atoms. It is demonstrated that the maximum push-pull effect is not always between the strong electron-donating D and strong electron-accepting A groups in D-π-A compounds The action mode of push-pull effect of substituents in D-π-A compounds is dominated by their mol. parent structure. The contribution of field/inductive effect and conjugative effect of a group to the push-pull effect is unequal. When the D-π-A parent mol. is in a plane, the influence of field/inductive effect of a group on the push-pull effect is greater than or close to that of its conjugative effect does. Although the parent mol. is sterically twisted, the push-pull effect is mainly dependent on the conjugative effect of a group. The results of this paper can provide us a new insight into the push-pull effect of substituents.

Journal of Physical Organic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hu, Bin-bin published the artcileSynthesis of N-alkyl-carbazole-3, 6-dicarbaldehyde, Application In Synthesis of 23616-79-7, the publication is Huaxue Shiji (2013), 35(7), 589-592, database is CAplus.

Using benzyltributylammonium chloride as phase transfer catalyst and 50% NaOH aqueous solution as acid binding agent, carbazole reacted with alkyl halides in mole ratio 1:1.2 at reflux in benzene for 3∼4 h to produce alkylcarbazoles. Then the resulting alkylcarbazoles reacted with fourfold equivalent freshly distilled DMF and POCl₃ in chlorobenzene to obtain the title compounds Structures of the products were confirmed by ¹HNMR and IR.

Huaxue Shiji published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Application In Synthesis of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jiang, Jun published the artcileSynthesis of N-arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Organic & Biomolecular Chemistry (2018), 16(27), 5016-5020, database is CAplus and MEDLINE.

A fascinating Fe-promoted protocol for the synthesis of N-arylsulfonamides has been developed. Starting from com. available nitroarenes R¹NO₂ (R¹ = Ph, 2-ClC₆H₄, 4-HOC₆H₄, 1,2,4-triazol-3-yl, etc.) and sulfonyl chlorides R²SO₂Cl (R² = Me, Ph, 3-BrC₆H₄, 2-naphthyl, 2-thienyl, etc.), moderate to excellent yields of the corresponding N-arylsulfonamides R¹NHSO₂R² can be obtained. In particular, Fe dust serves as the sole reductant in the transformation and it can be easily performed on a large scale.

Organic & Biomolecular Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cai, Yingying published the artcileDouble allylic defluorinative alkylation of 1,1-bisnucleophiles with (trifluoromethyl)alkenes: construction of all-carbon quaternary centers, Application In Synthesis of 864725-22-4, the publication is Organic Chemistry Frontiers (2020), 7(10), 1260-1265, database is CAplus.

A double allylic defluorinative alkylation reaction of 1,1-bisnucleophiles such as C₆H₅CH₂ R (R = H, Ph, C(O) C₆H₅, C(O)OEt, etc.), nitriles R¹CH₂CN (R¹ = Ph, thiophen-2-yl, n-decyl, etc.)and indolin-2-one with (trifluoromethyl)alkenes CH₂=C(R²)CF₃ (R² = Ph, naphthalen-2-yl, pyridin-3-yl, etc.) is reported that occurs via the exclusively regioselective SN2 reaction. Various aliphatic nitriles, esters, and indolin-2-one derivatives could serve as 1,1-bisnucleophiles, delivering diverse attractive sym. gem-difluoroalkene substituted products e.g., I in high yields via the construction of all-carbon quaternary centers. Interestingly, the chemoselective SNV reaction between gem-difluoroalkenes and nucleophiles is completely inhibited. The nitrile group might help to stabilize the α-carbanion intermediates.

Organic Chemistry Frontiers published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Application In Synthesis of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Ming-bo published the artcileSynthesis and structure-activity relationship of novel tetrahydrobenzo[d]thiazole as androgen receptor modulator, Related Products of chlorides-buliding-blocks, the publication is Zhongguo Shengwu Huaxue Yu Fenzi Shengwu Xuebao (2018), 34(9), 962-971, database is CAplus.

Prostate cancer is one of the most commonly diagnosed cancer in men, and androgen receptor (AR) is an important target for the treatment of prostate cancer. For many reasons, existing AR antagonists fail to treat prostate cancer after long-term use. Therefore, the development of novel AR antagonists is still of great significance. A series of tetrahydrobenzo[d]thiazole compounds were synthesized by condensation reaction of α,β-epoxycyclohexanones and appropriate substituted thioureas 8, which were obtained from the corresponding anilines 7. Their antiandrogenic activities were tested using an yeast two-hybrid (Y2H) system, and several compounds exhibited androgen receptor (AR) antagonistic behavior equal or stronger than that of flutamide (IC₅₀ ≤ 2.48 mmol/L). Further cell viability assay demonstrated that some active compounds effectively inhibited the proliferation of androgen-sensitive LNCaP cells values with IC₅₀ values of 17.1-41.4 mmol/L. Mol. docking study provide a possible model of ligand receptor interactions, which was consistent with the initial structure-activity relationship (SAR) studies. Taken together, tetrahydrobenzo[d]thiazoles act as effective AR modulators may represent promising leads for further development of novel and improved AR antagonists.

Zhongguo Shengwu Huaxue Yu Fenzi Shengwu Xuebao published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C10H16Br3N, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Galatenko, N. A. published the artcileStudy of the properties of a plastic composition for bone tissue with antiseptic action, Formula: C38H74Cl2N2O4, the publication is Dopovidi Natsional’noi Akademii Nauk Ukraini (2005), 128-133, database is CAplus.

The polymeric composition containing bioactive components and an antiseptic were developed for bone implants. By changing the structure and content of osteoapatite, it was possible to achieve the regulation of the durability of a composite and the output of a medical substance from the polyurethane matrix.

Dopovidi Natsional’noi Akademii Nauk Ukraini published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics