Author: Jessica.F

Li, Xu-Jun published the artcileSynthesis and fungicidal activity of phenazine-1-carboxylic triazole derivatives, Computed Properties of 620-20-2, the publication is Journal of Asian Natural Products Research (2021), 23(5), 452-465, database is CAplus and MEDLINE.

A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamines I [R = 3-MeC₆H₄, 2-FC₆H₄, 2,4-Cl₂C₆H₃, etc.] and 10 novel-substituted 3-benzylmercapto-1,2,4-triazole derivatives II were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by ¹H-NMR, ¹³C-NMR, HRMS and X-ray. Most substituted 3-benzylmercapto-1,2,4-triazole derivatives II displayed very strong fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Compounds II [R = 4-MeC₆H₄, 4-iPrC₆H₄, 4-tBuC₆H₄, etc.] showed a broad spectrum of fungicidal activity. Further field experiments indicated that compounds II [R = 4-MeC₆H₄, 2-FC₆H₄, 4-iPrC₆H₄, etc.] displayed better efficacy against rice blast (Pyricularia oryzae) than PCA. These data demonstrated that compounds II [R = 4-MeC₆H₄, 2-FC₆H₄, 4-iPrC₆H₄, etc.] were promising fungicidal candidates, deserving further studies.

Journal of Asian Natural Products Research published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Jie-long published the artcileGreen synthesis of germicide Prochloraz, Category: chlorides-buliding-blocks, the publication is Huaxue Shiji (2010), 32(9), 856-858, database is CAplus.

Prochloraz is a broad-spectrum imidazole germicide. The synthesis of the target compound [i.e., N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide, Prochloraz, Mirage, Preclude, Sportake, etc.] was achieved using using 2,4,6-trichlorophenol, 1,2-ethanediol, imidazole and triphosgene as starting materials in an environmentally friendly synthetic sequence (green chem.).

Huaxue Shiji published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C4H7F3O2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Feng published the artcileCatalytic and Photochemical Strategies to Stabilized Radicals Based on Anomeric Nucleophiles, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Journal of the American Chemical Society (2020), 142(25), 11102-11113, database is CAplus and MEDLINE.

Carbohydrates, one of the three primary macromols. of living organisms, play significant roles in various biol. processes such as intercellular communication, cell recognition, and immune activity. While the majority of established methods for the installation of carbohydrates through the anomeric carbon rely on nucleophilic displacement, anomeric radicals represent an attractive alternative because of their functional group compatibility and high anomeric selectivities. Herein, we demonstrate that anomeric nucleophiles such as C1 stannanes can be converted into anomeric radicals by merging Cu(I)-catalysis with blue light irradiation to achieve highly stereoselective C(sp3)-S cross-coupling reactions. Mechanistic studies and DFT calculations revealed that the C-S bond-forming step occurs via the transfer of the anomeric radical directly to a sulfur electrophile bound to Cu(II) species. This pathway complements a radical chain observed for metal-free conditions where a disulfide initiator can be activated by a Lewis base additive. Both strategies utilize anomeric nucleophiles as efficient radical donors and achieve a switch from an ionic to a radical pathway. Taken together, the stability of glycosyl nucleophiles, a broad substrate scope, and high anomeric selectivities observed for the thermal and photochem. protocols make this novel C-S cross-coupling a practical tool for late-stage glyco-diversification of bioactive natural products and drug candidates.

Journal of the American Chemical Society published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C4H5BN2O2, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yao, Qi-Jun published the artcileAtroposelective Synthesis of Axially Chiral Biaryls by Palladium-Catalyzed Asymmetric C-H Olefination Enabled by a Transient Chiral Auxiliary, Name: 4-Chloro-2-methylphenylboronic acid, the publication is Angewandte Chemie, International Edition (2017), 56(23), 6617-6621, database is CAplus and MEDLINE.

Atroposelective synthesis of axially chiral biaryls by palladium-catalyzed C-H olefination, using tert-leucine as an inexpensive, catalytic, and transient chiral auxiliary, has been realized. This strategy provides a highly efficient and straightforward access to a broad range of enantioenriched biaryls, e.g., I (X-rays single crystal structure shown), in good yields (up to 98 %) with excellent enantioselectivities (95 to >99 % ee). Kinetic resolution of trisubstituted biaryls bearing sterically more demanding substituents is also operative, thus furnishing the optically active olefinated products with excellent selectivity (95 to >99 % ee, s-factor up to 600).

Angewandte Chemie, International Edition published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C10H14O, Name: 4-Chloro-2-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Hu published the artcileHydrosilylation of alkenes catalyzed by MCM-48 supported chitosan-platinum complex, Formula: C9H20Cl2Si, the publication is Hangzhou Shifan Daxue Xuebao, Ziran Kexueban (2012), 11(3), 217-221, database is CAplus.

A new Pt/CS-MCM-48 catalysts was prepared from chitosan supported on MCM-48. The catalyst was characterized by XRD, IR and TG. The results indicated that coordination bond between platinum and nitrogen atom of chitosan was formed. Pt/CS-MCM-48 catalyst has favorable catalytic performance for the hydrosilylation of alkenes, the regioselectivity of adduct is above 90%, and the catalyst can be reused for 14 times without noticeable loss of activity.

Hangzhou Shifan Daxue Xuebao, Ziran Kexueban published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C11H24O3, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bai, Ying published the artcileUse of functionalized PEG with 4-aminobenzoic acid stabilized platinum nanoparticles as an efficient catalyst for the hydrosilylation of alkenes, Name: Dichloro(hexyl)(methyl)silane, the publication is Journal of Colloid and Interface Science (2013), 428-433, database is CAplus and MEDLINE.

A catalyst containing functionalized polyethylene glycol with 4-aminobenzoic acid (PEG-AMB) stabilized Pt nanoparticles was synthesized and characterized, and its application in the hydrosilylation of alkenes studied. The functionalized PEG-stabilized Pt nanoparticles form a very efficient catalyst for the hydrosilylation of alkenes. The Pt nanoparticles can be fully immobilized in the PEG-AMB and recycled at least nine times without any obvious loss of catalytic activity.

Journal of Colloid and Interface Science published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Name: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bai, Ying published the artcileUse of functionalized PEG with 4-aminobenzoic acid stabilized platinum nanoparticles as an efficient catalyst for the hydrosilylation of alkenes, Synthetic Route of 14799-93-0, the publication is Journal of Colloid and Interface Science (2013), 428-433, database is CAplus and MEDLINE.

A catalyst containing functionalized polyethylene glycol with 4-aminobenzoic acid (PEG-AMB) stabilized Pt nanoparticles was synthesized and characterized, and its application in the hydrosilylation of alkenes studied. The functionalized PEG-stabilized Pt nanoparticles form a very efficient catalyst for the hydrosilylation of alkenes. The Pt nanoparticles can be fully immobilized in the PEG-AMB and recycled at least nine times without any obvious loss of catalytic activity.

Journal of Colloid and Interface Science published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Synthetic Route of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Cunpu published the artcileStudy of side-chain effects on the properties of anion-exchange membrane with in situ photoswitch, Quality Control of 219537-97-0, the publication is Chemistry Letters (2014), 43(9), 1493-1495, database is CAplus.

A crosslinked anion-exchange membrane (AEM) with an in situ photoswitch was synthesized. The side-chain effects on the properties of the AEM were studied using the same membrane sample in different status. The variances between the different samples were eliminated. The hydroxide conductivity of AEM could be increased by reducing the distance between the cations.

Chemistry Letters published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Quality Control of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Kai published the artcileSynthesis of Diboronic Acid-Based Fluorescent Probes for the Sensitive Detection of Glucose in Aqueous Media and Biological Matrices, HPLC of Formula: 209919-30-2, the publication is ACS Sensors (2021), 6(4), 1543-1551, database is CAplus and MEDLINE.

Reliable and accurate glucose detection in biol. samples is of great importance in clin. diagnosis and medical research. Chem. probes are advantageous in simple operation and flexible design, especially for the development of fluorescent probes. Anthracene-based diboronic acid (P-DBA) has shown potential in glucose probing because of its high sensitivity. However, poor solubility limits its applications in aqueous media. In this work, we systemically modify P-DBA by introducing fluoro (F-), chloro (Cl-), methoxyl (MeO-), or cyano (CN-) substituents. Among these probes, the cyano-substituted probe (CN-DBA) displays the highest glucose-binding constant (6489.5 M^-1, 33% MeOH). More importantly, it shows good water solubility in the aqueous solution (0.5% MeOH), with ultrasensitive recognition with glucose (LOD = 1.51 μM) and robust sensing from pH 6.0 to 9.0. Based on these features, the CN-DBA is finally applied to detect glucose in cell lysates and plasma, with satisfactory recovery and precision. These results demonstrate that CN-DBA could serve as an accurate, sensitive fluorescent probe for glucose assays in biol. samples.

ACS Sensors published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C15H22BBrO3, HPLC of Formula: 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Xiao-Lei published the artcileNatural product neopeltolide as a cytochrome bc₁ complex inhibitor: Mechanism of action and structural modification, Formula: C6H3ClFNO2, the publication is Journal of Agricultural and Food Chemistry (2019), 67(10), 2774-2781, database is CAplus and MEDLINE.

The marine natural product neopeltolide was isolated from a deep-water sponge specimen of the family Neopeltidae. Neopeltolide has been proven to be a new type of inhibitor of the cytochrome bc₁ complex in the mitochondrial respiration chain. However, its detailed inhibition mechanism has remained unknown. In addition, neopeltolide is difficult to synthesize because of its very complex chem. structure. In the present work, the binding mode of neopeltolide was determined for the first time by integrating mol. docking, mol. dynamics simulations, and mol. mechanics Poisson-Boltzmann surface area calculations, which showed that neopeltolide is a Q_o site inhibitor of the bc₁ complex. Then, according to guidance via inhibitor-protein interaction anal., structural modification was carried out with the aim to simplify the chem. structure of neopeltolide, leading to the synthesis of a series of new neopeltolide derivatives with much simpler chem. structures. The calculated binding energies (ΔG_cal) of the newly synthesized analogs correlated very well (R² = 0.90) with their exptl. binding free energies (ΔG_exp), which confirmed that the computational protocol was reliable. Compound 45, bearing a di-Ph ether fragment, was successfully designed and synthesized as the most potent candidate (IC₅₀ = 12 nM) against porcine succinate cytochrome c reductase. The mol. modeling results indicate that compound 45 formed a π-π interaction with Phe274 and two hydrogen bonds with Glu271 and His161. The present work provides a new starting point for future fungicide discovery to overcome the resistance that the existing bc₁ complex inhibitors are facing.

Journal of Agricultural and Food Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C12H14N2O2, Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics