Author: Jessica.F

Chen, Zhifang published the artcileMerging Imidazolidines with a Trifluoromethylated Tetrasubstituted Carbon through Tungsten Catalyzed 1,3-Dipolar Cycloaddition, HPLC of Formula: 5860-95-7, the publication is Journal of Organic Chemistry (2021), 86(11), 7714-7724, database is CAplus and MEDLINE.

An unprecedented 1,3-dipole cycloaddition between acyclic CF₃-ketimines and N-benzyl azomethine ylide has been allowed by tungsten catalysis, furnishing a range of novel imidazolidines bearing a trifluoromethylated tetrasubstituted carbon center. This reaction appears as one of rare examples that challenging acyclic CF₃-ketimines have been engaged in 1,3-cycloaddition reactions. The capability for gram-scale synthesis and variant derivatizations of cycloaddition adducts illustrates the synthetic potential of this approach. This protocol provides a facile access to a rapidly enlarging pool of motifs with a trifluoromethylated fully substituted carbon.

Journal of Organic Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, HPLC of Formula: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gong, Kai published the artcileFrom symmetrical tetrasulfides to trisulfide dioxides via photocatalysis, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Green Chemistry (2021), 23(24), 9865-9869, database is CAplus.

A straightforward strategy involving photocatalysis has been established for accessing trisulfide dioxides R¹SSSO₂R² (R¹ = Et, t-Bu, 1-adamantyl, 2-MeC₆H₄, etc.; R² = cyclopropyl, Ph, 4-FC₆H₄, 2-thienyl, etc.) from readily achieved sym. tetrasulfides R¹S₄R¹ and sulfinic acids R²SO₂H. Stern-Volmer anal. and radical quenching experiments demonstrated the occurrence of a single electron transfer between the photocatalyst and sulfinic acid. Bioactive mols. such as the antihypertensive drug captopril, allicin derivatives, amino acids and terpenes were efficiently and reversibly linked through sulfur-sulfur covalent bonds. Furthermore, flow-setup syntheses of trisulfide dioxides were successfully achieved on the gram scale, indicating the great potential of the developed protocol for practical industrial applications.

Green Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Lixin published the artcilePalladium-Catalyzed Dehydrogenative Difunctionalization of Aminoalkenes with Aminals as Oxidants and Electrophiles, SDS of cas: 21286-54-4, the publication is Organic Letters (2017), 19(17), 4600-4603, database is CAplus and MEDLINE.

A novel palladium-catalyzed aminomethylamination of aminoalkenes with an aminal, functioning not only as an aminomethylation reagent but also as an oxidant, was developed. This direct and operationally simple protocol provides a fundamentally novel and unique approach toward the synthesis of 2-(2-aminoethyl)indoles, e.g., I, and 2-(2-aminoethyl)pyrrolidines, e.g., II (X-rays single crystal structures for both compounds shown), which are important building blocks in synthetic organic chem. The unity of this method was highlighted by the rapid synthesis of Alosetron, a drug used for the treatment of irritable bowel syndrome.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, SDS of cas: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Renxiang published the artcileModified and Scalable Synthesis of N-Tosyl-4-Chlorobenzenesulfonimidoyl Fluoride (SulfoxFluor): Direct Imidation of Sulfinyl Chlorides with Chloramine-T Trihydrate, Category: chlorides-buliding-blocks, the publication is Organic Process Research & Development (2022), 26(2), 380-386, database is CAplus.

A general and practical method for the preparation of N-Tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor) and its adaptation to a large scale was disclosed. Starting from readily available 4-chlorobenzenesulfonyl chloride, chloramine-T trihydrate and potassium fluoride, SulfoxFluor was prepared on a hectogram scale in 63% overall yield with simple purification techniques. The use of chloramine-T trihydrate (instead of anhydrous chloramine-T) was a significant improvement over previous work, which streamlined the process and avoided the risk of explosion during drying or heating. This research not only established a reliable method for the scale-up synthesis of SulfoxFluor but also provided an insight into the imidation of sulfinyl chlorides with chloramine-T in the presence of water.

Organic Process Research & Development published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zheng, Haiyan published the artcileOptic and proton dual-control of fluorescence of Rhodamine based on photochromic diarylethene: mimicking the performance of an integrated logic gate, SDS of cas: 219537-97-0, the publication is Tetrahedron Letters (2009), 50(14), 1588-1592, database is CAplus.

A proton and optic dual-responsive fluorescence switch dyad which contains Rhodamine and photochromic diarylethene has been designed and an integrated logic circuit at the mol. level has been proposed.

Tetrahedron Letters published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C9H9N3, SDS of cas: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gu, Huifen published the artcileSeparation and identification of mustard gas compounds in diesel fuel, Category: chlorides-buliding-blocks, the publication is Fenxi Ceshi Xuebao (1995), 14(3), 6-9, database is CAplus.

Separation and identification of mustard and mustard disulfide in diesel fuel and aromatic compound mixtures are presented. Samples were prepurified by column chromatog. using hexane as eluate, and interfering matrixes were removed. Pure compounds were obtained with thin-layer chromatog. by developing the TLC plate twice in hexane and identified with gas chromatog.-mass spectrometry and NMR spectrometry.

Fenxi Ceshi Xuebao published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cao, Xinhua published the artcileFluorescence and Morphology Modulation in a Photochromic Diarylethene Self-Assembly System, COA of Formula: C15H14Cl2S2, the publication is Langmuir (2011), 27(8), 5090-5097, database is CAplus and MEDLINE.

Switchable supramol. self-assemblies on the basis of interaction between melamine group containing photochromic diarylethene unit (DTE) and naphthalimide derivate (1) were designed and fabricated. 1 can gelate several aprotic solvents with different morphologies. The gel turned into partial gel in Et acetate with the addition of DTE as a guest mol. Both the absorption and fluorescence spectra of the assembly can be reversibly switched by alternating UV/visible light irradiation Meanwhile, the morphol. of the coassembly of 1₂·DTE changed to film from original pieces of gel 1 in Et acetate. When 1₂·DTE was irradiated by UV light, the film morphol. was converted into aggregated flakes. Moreover, the surface wettability of the complex can also be switched by light irradiation The photochromic diarylethene unit is able to modulate the fluorescence and morphol. of the assembled system only by virtue of light irradiation Therefore, these results provide further insights into fluorescence and morphol. controlling, especially application in upscale smart responsive materials.

Langmuir published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, COA of Formula: C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zheng, Yue published the artcileStructure-activity relationship studies of c-di-AMP synthase inhibitor, bromophenol-thiohydantoin, Formula: C7H4BrClO2, the publication is Tetrahedron (2016), 72(25), 3554-3558, database is CAplus.

C-di-AMP, a bacterial second messenger, regulates various processes in Gram-pos. bacteria and mycobacteria. Small mol. inhibitors of c-di-AMP metabolic enzymes could affect bacterial growth and viability. A medium throughput screening identified bromophenol-thiohydantoin (BTH) as the first inhibitor of c-di-AMP synthase, DisA. Herein, the authors performed SAR studies of bromophenol-thiohydantoin to identify the salient features on BTH that are important for DisA inhibition. Seemingly minor substitution changes (e.g., aromatic bromo to chloro substitutions) resulted in dramatic changes in ligand potency. Bromophenol TH is specific for c-di-AMP synthase and did not inhibit RocR (c-di-GMP PDE), YybT (c-di-AMP PDE) or WspR (c-di-GMP synthase).

Tetrahedron published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C14H14, Formula: C7H4BrClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guan, Zhipeng published the artcileSelective radical cascade (4+2) annulation with olefins towards the synthesis of chroman derivatives via organo-photoredox catalysis, Related Products of chlorides-buliding-blocks, the publication is Chemical Science (2022), 13(21), 6316-6321, database is CAplus and MEDLINE.

Here a new (4 + 2) radical annulation approach for the construction of these functional six-membered frameworks I (R = ethoxycarbonyl, N-methyl-N-phenylcarbamoyl, benzenesulfonyl, (2,2,6,6-tetramethylpiperidin-1-yl)carbonyl, etc.; R¹ = H, Me, methoxycarbonyl; R² = H, Me, OMe; R³ = H, F, Ph, 2,2-dichlorocyclopropyl, etc.; R²R³ = -CH=CH-CH=CH-; R⁴ = H, Me, OMe, CF₃; R⁵ = H, Me;) via photocatalysis was reported. Featuring mild reaction conditions, the protocol allows readily available N-hydroxyphthalimide esters II and electron-deficient olefins RCH=CHR¹ to be converted into a wide range of valuable chromans I in a highly selective manner. Moreover, the present strategy can be used in the late-stage functionalization of natural product derivatives and biol. active compounds, which demonstrated the potential application. This method is complementary to the traditional Diels-Alder [4 + 2] cycloaddition reaction of ortho-quinone methides II and electron-rich dienophiles, since electron-deficient dienophiles were smoothly transformed into the desired chromans I.

Chemical Science published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lunagariya, Jignesh published the artcileDesign and synthesis of analogues of marine natural product galaxamide, an N-methylated cyclic pentapeptide, as potential anti-tumor agent in vitro, HPLC of Formula: 42074-68-0, the publication is Marine Drugs (2016), 14(9), 161/1-161/22, database is CAplus and MEDLINE.

Herein, we report design and synthesis of novel 26 galaxamide analogs with N-methylated cyclo-pentapeptide, and their in vitro anti-tumor activity towards the panel of human tumor cell line, such as, A549, A549/DPP, HepG2 and SMMC-7721 using MTT assay. We have also investigated the effect of galaxamide and its representative analogs on growth, cell-cycle phases, and induction of apoptosis in SMMC-7721 cells in vitro. Reckon with the significance of conformational space and N-Me aminoacid (aa) comprising this compound template, we designed the analogs with modification in N-Me-aa position, change in aa configuration from l to d aa and substitute one Leu-aa to d/l Phe-aa residue with resp. to the parent structure. The efficient solid phase parallel synthesis approach is employed for the linear pentapeptide residue containing N-Me aa, followed by solution phase macrocyclisation to afford target cyclo pentapeptide compounds In the present study, all galaxamide analogs exhibited growth inhibition in A549, A549/DPP, SMMC-7721 and HepG2 cell lines. Compounds 6, 18, and 22 exhibited interesting activities towards all cell line tested, while Compounds 1, 4, 15, and 22 showed strong activity towards SMMC-7221 cell line in the range of 1-2 μg/mL IC50. Flow cytometry experiment revealed that galaxamide analogs namely Compounds 6, 18, and 22 induced concentration dependent SMMC-7721 cell apoptosis after 48 h. These compounds induced G0/G1 phase cell-cycle arrest and morphol. changes indicating induction of apoptosis. Thus, findings of our study suggest that the galaxamide and its analogs 6, 18 and 22 exerted growth inhibitory effect on SMMC-7721 cells by arresting the cell cycle in the G0/G1 phase and inducing apoptosis. Compound 1 showed promising anti-tumor activity towards SMMC-7721 cancer cell line, which is 9 and 10 fold higher than galaxamide and reference DPP (cisplatin), resp.

Marine Drugs published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, HPLC of Formula: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics