Author: Jessica.F

Hamdy, Rania published the artcileDesign and synthesis of new drugs inhibitors of Candida albicans hyphae and biofilm formation by upregulating the expression of TUP1 transcription repressor gene, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is European Journal of Pharmaceutical Sciences (2020), 105327, database is CAplus and MEDLINE.

Here, new compounds were designed to selectively inhibit C. albicans hyphae formation without affecting human cells to afford sufficient safety. The newly designed 5-[3-substitued-4-(4-substituedbenzyloxy)-benzylidene]-2-thioxo-thiazolidin-4-one derivatives, named SR, I (R¹ = 4-Me, 4-CF₃, 3-CF₃; R² = OMe, Cl, Br) showed very specific and effective inhibition activity against C. albicans hyphae formation. SR compounds caused hyphae inhibition activity at concentrations 10-40 fold lower than the concentration required to inhibit Candida yeast and bacterial growths. The anti-hyphae inhibition activities of SR compounds were via activation of the hyphae transcription repressor gene, TUP1. Correlation studies between the expression of TUP1 gene and the activity of SR compounds confirmed that the anti-C. albicans activities of SR compounds were via inhibition of hyphae formation. The newly designed SR compounds showed 10-40% haemolytic activity on human erythrocytes when compared to 100% haemolysis by 0.1% triton employed as pos. control. Furthermore, theor. prediction of absorption, distribution, metabolism, excretion, and toxicity (ADMET) of SR compounds confirmed their safety, efficient metabolism and possible oral bioavailability. With the minimal toxicity and significant activity of the newly-designed SR compounds, a future optimization of pharmaceutical formulation may develop a promising inhibitor of hyphal formation not only for C. albicans but also for other TUP1-dependent dimorphic fungal infections.

European Journal of Pharmaceutical Sciences published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

El-Sakka, Sahar Said published the artcileBehaviour of 4-[4-methoxy-3-methylphenyl]-4-oxobutenoic acid towards nitrogen-containing nucleophiles, SDS of cas: 3696-23-9, the publication is Journal of Chemical Sciences (Bangalore, India) (2014), 126(6), 1883-1891, database is CAplus.

A series of novel amino acid derivatives has been synthesized by the reaction of 4-[4-methoxy-3-methylphenyl]-4-oxobutenoic acid with primary and secondary amines. The treatment of amino acids with hydrazine afforded pyridazine. Phenylhydrazone was obtained from the reaction of the acid with Ph hydrazine in ethanol. On the other hand, the acid underwent heterocyclization upon the treatment with 2-aminopyridine, o-phenylenediamine, aryldithiocarbamates and thiourea derivatives to give the corresponding pyridopyrimidine, quinoxalone, 2-thioxo-1,3-thiazole and 4-hydroxy-1,3-thiazole, resp. The thiazolopyridazine derivatives were obtained from the reaction of 4-hydroxy-1,3-thiazole with hydrazine and phenylhydrazine, resp. The behavior of the 4-hydroxy-1,3-thiazole toward acetic anhydride and bromine was also studied. Some of the synthesized compounds also exhibited anti-microbial activities.

Journal of Chemical Sciences (Bangalore, India) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, SDS of cas: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hahn, Witold E. published the artcileDicarboxylic acid imides. VI. N-Aminoalkoxyphenyl derivatives of 4-cyclohexene-1,2-dicarboximide, Computed Properties of 4584-49-0, the publication is Acta Poloniae Pharmaceutica (1980), 37(4), 403-8, database is CAplus.

Eighteen imide derivatives (I; n = 2, 3; R = Me, Et, Me₂CH, 1-piperidinyl, 1-pyrrolidinyl) were prepared by reaction of Cl(CH₂)_nNR₂ with the corresponding phenolic compound (II) in Me₂CO in the presence of K₂CO₃. An alternative route of synthesis involved the reaction of II with Br(CH₂)_nBr and subsequent treatment of the thus formed III with R₂NH. Hypotensive and psychotropic activity of several I was claimed.

Acta Poloniae Pharmaceutica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Computed Properties of 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhebentyaev, A. I. published the artcileElectron and infrared spectra of eosin complexes with nitrogen-containing drugs, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Farmatsiya (Moscow, Russian Federation) (1991), 40(6), 28-31, database is CAplus.

The interaction of eosin with some nitrogen-containing drugs decamethoxin and papaverine was examined by using UV, IR, and spectrophotometric methods in the visible region. The OH-group of eosine was implicated in the complex formation. The mechanism responsible for the complex formation is discussed in the study.

Farmatsiya (Moscow, Russian Federation) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C18H20N2O12, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tomashevskii, A. A. published the artcileReaction of (α-haloalkyl)thiiranes with nucleophilic reagents. I. Reaction with morpholine, HPLC of Formula: 18791-02-1, the publication is Zhurnal Organicheskoi Khimii (1994), 30(10), 1528-36, database is CAplus.

D-labeling experiments showed that (chloromethyl)thiirane reacts with morpholine by a mechanism involving initial ring cleavage and subsequent recyclization. In the case of (bromomethyl)thiirane, direct substitution of Br competes with this mechanism. Reactions of morpholine with 2-(chloromethyl)-2-methylthiirane, 3-(chloromethyl)-2,2-dimethylthiirane, and diastereoisomers of (1-chloroethyl)thiirane were also examined

Zhurnal Organicheskoi Khimii published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C5H5BrN2, HPLC of Formula: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gotsko, Maxim D. published the artcileTopochemical mechanoactivated phosphonylethynylation of pyrroles with chloroethynylphosphonates on solid Al₂O₃ or K₂CO₃ media, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Tetrahedron Letters (2015), 56(32), 4657-4660, database is CAplus.

Dialkyl 2-(1H-pyrrol-2-yl)ethynylphosphonates have been synthesized from their resp. pyrroles by a transition metal-free, topochem. mechanoactivated phosphonylethynylation (room temperature, 24-48 h) using chloroethynylphosphonates on solid Al₂O₃ (40-58% yield) or K₂CO₃ (38-43% yield).

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Skobeeva, V. published the artcileSynthesis of silver nanoparticles and therapeutic films for ophthalmology based on them, Product Details of C38H74Cl2N2O4, the publication is Springer Proceedings in Physics (2020), 179-188, database is CAplus.

This article presents the results of the silver nanoparticles synthesis by a simple and ecol. method of chem. reduction of silver from silver nitrate in an aqueous solution of sodium citrate and their use in the treatment of eye diseases. The technol. conditions that lead to formation of silver nanoparticles with spherical shape and size of 30 nm with an intensive band of surface plasmon resonance are established. The effect of the application of therapeutic films with nanoparticles on the ultrastructure of the epithelium and stroma of the cornea of a rabbit after modeling in animals of moderately severe bacterial keratitis has been studied. It has been established that the application of therapeutic films with silver nanoparticles, as compared with antibiotics, leads to more efficient regeneration of the anterior corneal epithelium, contributes to the rapid restoration of the stroma and active formation of the delicate collagen skeleton typical of healthy corneal tissue.

Springer Proceedings in Physics published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C8H5F3O3, Product Details of C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rehak, Vladimir published the artcileComparison of linear and branched nonpolar chemically bonded stationary phases in high-performance liquid chromatography, Application In Synthesis of 14799-93-0, the publication is Journal of Chromatography (1980), 191(1), 71-9, database is CAplus.

Nonpolar chem. bonded stationary phases with branched or unbranched structure were synthesized, and their sp. surface areas, pore size distributions, and C contents were estimated Based on these data the number of silane mols. bonded to unit surface area of the original silica gel was calculated for each phase. Retentions of selected solute groups were measured in 4 mobile phases of various elution strength, prepared from MeOH-H₂O mixtures at various ratios. Dependence of k‘ on the length of the “bristle”, on the size and structure of the solute mol., and the elution strength of the mobile phase were plotted. Results are compared for pairs of phases having different structures but either the same total number of C atoms in the bonded mol. or the same length of the “bristle”. The synthesis of several halosilanes used for preparation of the bonded phases is described.

Journal of Chromatography published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Application In Synthesis of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hwang, Jong Yeon published the artcileOptimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei, COA of Formula: C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(14), 4127-4131, database is CAplus and MEDLINE.

We previously reported the phenylchloronitrobenzamides (PCNBs), a novel class of compounds active against the species of trypanosomes that cause Human African Trypanosomiasis (HAT). Herein, we explored the potential to adjust the reactivity of the electrophilic chloronitrobenzamide core. These studies identified compound 7d that potently inhibited the growth of trypanosomes (EC₅₀ = 120 nM for Trypanosoma b. brucei, 18 nM for Trypanosoma b. rhodesiense, and 38 nM for Trypanosoma b. gambiense) without significant cytotoxicity against mammalian cell lines (EC₅₀ > 25 μM for HepG2, HEK293, Raji, and BJ cell lines) and also had good stability in microsomal models (t_1/2 > 4 h in both human and mouse). Overall these properties indicate the compound 7d and its analogs are worth further exploration as potential leads for HAT.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, COA of Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lankova, Martina published the artcileAuxin influx inhibitors 1-NOA, 2-NOA, and CHPAA interfere with membrane dynamics in tobacco cells, Product Details of C8H7ClO3, the publication is Journal of Experimental Botany (2010), 61(13), 3589-3598, database is CAplus and MEDLINE.

The phytohormone auxin is transported through the plant body either via vascular pathways or from cell to cell by specialized polar transport machinery. This machinery consists of a balanced system of passive diffusion combined with the activities of auxin influx and efflux carriers. Synthetic auxins that differ in the mechanisms of their transport across the plasma membrane together with polar auxin transport inhibitors have been used in many studies on particular auxin carriers and their role in plant development. However, the exact mechanism of action of auxin efflux and influx inhibitors has not been fully elucidated. In this report, the mechanism of action of the auxin influx inhibitors (1-naphthoxyacetic acid (1-NOA), 2-naphthoxyacetic acid (2-NOA), and 3-chloro-4-hydroxyphenylacetic acid (CHPAA)) is examined by direct measurements of auxin accumulation, cellular phenotypic anal., as well as by localization studies of Arabidopsis thaliana auxin carriers heterologously expressed in Nicotiana tabacum, cv. Bright Yellow cell suspensions. The mode of action of 1-NOA, 2-NOA, and CHPAA has been shown to be linked with the dynamics of the plasma membrane. The most potent inhibitor, 1-NOA, blocked the activities of both auxin influx and efflux carriers, whereas 2-NOA and CHPAA at the same concentration preferentially inhibited auxin influx. The results suggest that these, previously unknown, activities of putative auxin influx inhibitors regulate overall auxin transport across the plasma membrane depending on the dynamics of particular membrane vesicles.

Journal of Experimental Botany published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Product Details of C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics