Author: Jessica.F

Adding a certain compound to certain chemical reactions, such as: 309721-44-6, name is 2-Bromo-1-chloro-3-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 309721-44-6, Recommanded Product: 309721-44-6

40.0 g (1.0 eq) of Compound 1 (5,12-dihydroindolo [3,2-a] carbazole) and 26.27 g (1.5 eq) of Potassium tert-butoxide (KOtBu) were dissolved in dimethylformamide (DMF)And the mixture was heated and stirred.At the start of the reflux, 40.0 g (1.1 eq) of compound 1a (2-bromo-1-chloro-3-fluorobenzene) was added.After the reaction was completed after 3 hours, the reaction was poured into water and the crystals were dropped and filtered.The filtered solid was completely dissolved in chloroform (CHCl3), washed with water, and again reduced in pressure to remove the solvent. The residue was purified by column chromatography to obtain 49.5 g of Compound A-1 (yield: 71%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; LG Chem, Ltd.; Lee Jeong-ha; Park Tae-yun; (125 pag.)KR2017/126814; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, molecular formula is C6H3Cl3O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2,6-Dichlorobenzenesulfonyl chloride

General procedure: Step 3. To the solution of crude product 7 (255 mg, 1 mmol) in dry pyridine (5 mL, Sinopharm), corresponding sulfonyl chloride (1.5 mmol, Energy Chemical, Shanghai, China) was added and the mixture was stirred at room temperature. Then it was added to 10% aqueous HCl (50 mL, Sinopharm) and the suspension was extracted with ethyl acetate (Sinopharm). The organic phase was washed with brine, dried over anhydrous Na2SO4 and filtered. The residue was purified by silica chromatography after removal of ethyl acetate to give compounds 9a-q.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6579-54-0, its application will become more common.

Reference:
Article; Huang, Ke; Jiang, Lulu; Li, Huiti; Ye, Deyong; Zhou, Lu; Molecules; vol. 24; 5; (2019);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1513-25-3, name is 2-Chloro-1-fluoro-4-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H6ClF

Potassium ethoxide (1.74 g, 20.7 mmol) was dissolved in anhydrous diethyl ether (50 mL), was added dropwise diethyl oxalate (1g, 6.9mmol) in anhydrous diethyl ether (20mL) at room temperature, then added dropwise chloro-1-fluoro-4-methyl-benzene (1g, 6.9mmol) in anhydrous diethyl ether (20mL) at rt was stirred room temperature for 30 hours. Quenched with ice water, extracted with ethyl acetate, the organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated to give the crude product purified by column chromatography, to give ethyl 3-(3-chloro-4-fluorophenyl)-2-carbonylpropionate (610mg, yield 36%)

According to the analysis of related databases, 1513-25-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Liu Shiqiang; Zhou Yuanfeng; Bao Meng; Yuan Yida; Liu Lei; Bao Rudi; (57 pag.)CN109761986; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 98446-49-2, name is 2,4-Dichloro-5-methoxyaniline, molecular formula is C7H7Cl2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H7Cl2NO

To a stirred solution of 4-chloro-5-[3-(2-chloroethoxy)phenyl]nicotinonitrile (200 mg, 0.68 mmol), 2,4-dichloro-5-methoxyaniline (196 mg, 1 mmol), 2-dicyclohexylphosphino 2′(N,N-dimethylamino)biphenyl (80 mg, 0.20 mmol), and K3PO4 (216 mg, 1 mmol) in 4 mL anhydrous ethylene glycol dimethyl ether was added Pd2(dba)3 (62 mg, 0.07 mmol). The mixture was heated to 90 C. for 2 hours then cooled, filtered through Celite, concentrated in vacuo, and purified by silica gel chromatography eluding with 5-50% MeOH in CH2Cl2 to yield 160 mg of 5-[3-(2-chloroethoxy)phenyl]-4-[(2,4-dichloro-5-methoxyphenyl)amino]nicotinonitrile 150 as a solid (52%). HPLC retention time(c): 14.29 min.; MS: 448 [M+H].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 98446-49-2, its application will become more common.

Reference:
Patent; Cole, Derek Cecil; Asselin, Magda; Boschelli, Diane Harris; Wissner, Allan; Wang, Yanong Daniel; Prashad, Amarnauth Shastrie; Dushin, Russell; US2007/287738; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 6579-54-0, A common heterocyclic compound, 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, molecular formula is C6H3Cl3O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 1,3-Bis(aminomethyl)benzene (100 mg, 0.73 mmol) and 0.25 ml triethylamine in 20 ml dichloromethane was stirred at 0 C. To this solution was slowly added appropriate benzamide or benzenesulfonamide (2.2 mmol) in 20 ml dichloromethane dropwise. After 10 minutes, the reaction mixture was then placed to ambient temperature and stirred for 2 hours. Upon completion, the reaction mixture was concentrated under reduced pressure. Purification by flash chromatography (silica gel, dichloromethane/methanol 40: 1) afforded a white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Chen, Yanmei; Liu, Bo; Ouyang, Liang; Pan, Dabo; Xiang, Honggang; Zhang, Jifa; Zhang, Jin; Chinese Chemical Letters; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 39885-50-2, The chemical industry reduces the impact on the environment during synthesis 39885-50-2, name is 2-Chloro-4-(trifluoromethyl)aniline, I believe this compound will play a more active role in future production and life.

5-Amino-1-(2-chloro-4-trifluoromethylphenyl)-3-cyanopyrazole in the form of an orange crystalline solid, m.p. 133-135¡ãC, from 2-chloro-4-trifluoromethylaniline. 5-Amino-3-cyano-1-(2,4,6-trichlorophenyl)pyrazole in the form of a light brown solid, m.p. 155-156¡ãC, from 2,4,6-trichloroaniline

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-4-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RHONE-POULENC AGRICULTURE LIMITED; EP295117; (1988); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2453-46-5, name is Chlorocycloheptane, This compound has unique chemical properties. The synthetic route is as follows., Safety of Chlorocycloheptane

A 1.64 M THF solution of phenylmagnesium chloride (1.10 mL, 2.40 mmol) was added at 0 C. to 0.6 mL of a THF solution of aluminum chloride AlCl3 (80.0 mg, 0.60 mmol). The reaction mixture was stirred at room temperature for 1 hour. To the resulting solution was added 1,2-bis(bis(3,5-di-tert-butylphenyl)phosphino)benzene ([3,5-(t-Bu)2]-DPPBz) (13.4 mg, 0.015 mmol) and a 0.1 M THF solution of iron chloride FeCl3 (0.15 mL, 0.015 mmol) at 0 C., followed by chlorocycloheptane (66.3 mg, 0.5 mmol). The coupling reaction was performed at 80 C. for 24 hours. After cooling to room temperature, a portion of the reaction mixture was taken out, and the yield of the product was measured by gas chromatography (GC), using undecane as an internal standard. The yield was 94%. The results are shown in the Entry 5 column of Table 8.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2453-46-5.

Reference:
Patent; Kyoto University; US2011/152523; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 73006-78-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73006-78-7, name is 5-Chloro-[1,1′-biphenyl]-2-amine, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: (B) Under a nitrogen atmosphere, a 100 mL Schlenk flask was charged with 4′-(tert-butyl)-[1,1′-biphenyl]-2-amine (0.56g, 2.5 mmol) and THF (10 mL) at 0 oC with stirring. Acetic formic anhydride (2 mL), which was prepared from the reaction of acetic anhydride with formic acid (1.1 equiv) at 55 C for 2 h, was added dropwise with syringe. Then, the reaction mixture was warmed to room temperature for 2 h, treated with saturated NaHCO3, and extracted with EtOAc (3 ¡Á 25 mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated to dryness under reduced pressure. The residue was purified by column chromatography on silica gel using a mixture of petroleum ether and ethyl acetate (3:1 (v/v)) as eluents to afford N-(4′-(tert-butyl)-[1,1′-biphenyl]-2-yl)formamide as a yellow oil (0.60 g 95%).

The chemical industry reduces the impact on the environment during synthesis 5-Chloro-[1,1′-biphenyl]-2-amine. I believe this compound will play a more active role in future production and life.

Reference:
Article; Zhao, Cheng-Long; Shi, Jin; Lu, Xiuqiang; Wu, Xun; Zhang, Cheng-Pan; Journal of Fluorine Chemistry; vol. 226; (2019);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 309721-44-6, name is 2-Bromo-1-chloro-3-fluorobenzene, molecular formula is C6H3BrClF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H3BrClF

To a mixture of sodium tert-butoxide (138 mg, 1 .4 mmo) in THF (1.0 mL) was added I ,1 ,1 -trifiuoro-2-propano (0.14 mL, 1.5 mmo) and 2-bromo-1-choro-3-fluorobenzene (200 mg, 0.96 mmofl n DMF (2.0 rnL). The reacfion mxture was heated at 80 C for 24 h. After coohng to rt, EtOAc (5.0 mL) was added to the reacton rnxture and washed sequentaHy with 1 M HC (2.5 mL), saturated aqueous NaHCO3, and brine. The aqueous ayers were extractedw[th EEtOAc, and the combined organic extracts were dred (Na2SO4), ifitered and concentrated. Purflcaton by FCC (0 -10% EtOAc I hexanes) afforded the tWe compound as an o (87 rng, 30% yed). ?H NMR (400 MHz, CDC3) oe 7.23 (rn, 2H), 6.86 (dd, J = 7.3, 2.4 Hz, I H), 4.72 4.58 (m, 1 H), 1.62 – 1.49 (m, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 309721-44-6, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; RAVULA, Suchitra; SWANSON, Devin M.; SAVALL, Bradley M.; AMERIKS, Michael K.; (250 pag.)WO2016/176449; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 766545-20-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 766545-20-4 as follows.

0.4 g (0.002 mol) of 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride,0.53 g (0.0022 mol)3,4-dibromofuran-2 (5H) -one (synthesis, 2007, 12, 1887-1889, hereinafter the same)0.42 g (0.003 mol) of anhydrous potassium carbonate were successively added to a reaction flask equipped with 20 mL of N, N-dimethylformamide,The mixture was stirred at room temperature for 3 hours,TLC monitoring reaction is complete,Poured into water, extracted with 100 ml of ethyl acetate, washed with 100 ml of saturated brine, dried over anhydrous magnesium sulfate, concentrated under reduced pressure, and then purified by column chromatography (ethyl acetate: petroleum ether = 1: 3 to 1: 1) Pale yellow solid 0.13 g,

According to the analysis of related databases, 766545-20-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shenyang Sinochem Pesticide Chemical Research and Development Co., Ltd.; Yang, Jichun; Li, Miao; Fan, Xiaoxi; Yang, Fan; Li, Keke; Liu, Zhangling; (46 pag.)CN106467538; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics