Author: Jessica.F

Electric Literature of 157590-59-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 157590-59-5, name is 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

E. 6-Chloro-7-trifluoromethyl, 4-dihydro-2,3-quinoxalinedione A mixture of 3,4-diamino-6-chlorobenzotrifluoride (185 mg, 0.88 mmol) and oxalic acid dihydrate (117 mg, 0.93 mmol, used as received) in 2N HCl (4 mL) was refluxed at 170-5 C. for 3 h, then cooled to room temperature. The mixture was centrifuged and the liquid layer was removed. The yellow solid was washed twice by cold water (2*2 mL), collected by filtration, and dried at 60 C. with reduced pressure for 2 h, affording 180 mg of crude title compound (77.3%) as a light yellow powder. The crude product was dissolved in 1N NaOH (6 mL) and filtered. The filtrate was acidified to pH=6, affording 138 mg of title compound. It was recrystallized from DMSO/H2 O twice to give 102 mg of pure compound (43.9%) as yellow microcrystals. mp:>360 C. (dec. from 295 C.). IR (KBr, cm-1) 3425, 3200, 1731, 1706, 1625; 1400. 1 H NMR (DMSO-d6): delta7.274 (s, 1H); 7.478 (s, 1H); 12.145 (s, 2H). HRMS: calcd for C9 H4 ClF3 N2 O2 (M+) m/z: 263.9912; found: 263.9919.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California; US5514680; (1996); A;,
Chloride – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 367-22-6, name is 4-Chloro-3-fluoroaniline, A new synthetic method of this compound is introduced below., SDS of cas: 367-22-6

4-chloro-3-fluoroaniline (2g, 13.7 mmol) was dissolved in 60 mL of dichloromethane. Under ice bath, saturated sodium bicarbonate solution (60 mL) was added. The mixture was stirred at 0 C and triphosgene (1.36g, 4.58 mmol) was added. The mixture was stirred at 0 C for 1 hr and then extracted with dichloromethane and water. The organic layer was dried with sodium sulfate and filtered. The filtrate solution was concentrated and the residue was treated with 50 mL of hexanes. The hexane solution was concentrated to remove all solvents. The residue was dissolved in 12 mL of hexanes and filtered. The solution was concentrated and dried to give l-chloro-2-fluoro-4-isocyanatobenzene as an off white solid (1.69 g). 1H NMR (400 MHz, CHLOROFORM- )? ppm 6.82 – 6.90 (m, 1 H) 6.93 (dd, 7=9.22, 2.65 Hz, 1 H) 7.31 – 7.41 (m, 1 H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BROTHERTON-PLEISS, Christine E.; CHEN, Zhi; ERICKSON, Shawn David; KIM, Kyungjin; LI, Hongju; LOVEY, Allen John; QIAN, Yimin; SO, Sung-Sau; WOVKULICH, Peter Michael; YI, Lin; WO2014/60341; (2014); A1;,
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Application of 104-11-0,Some common heterocyclic compound, 104-11-0, name is 1-(4-Chlorophenyl)-N-methylmethanamine, molecular formula is C8H10ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The procedure is as follows: 3 mg of catalyst CoPz (hmdtn) 4 is weighed into a quartz jacketed photoreactor, and then 25 mL of a reaction solvent, acetonitrile (abbreviated as CH3CN), is added. CoPz(hmdtn)4 was completely dissolved in CH3CN under stirring. Further, 0.01 mmol of the auxiliary 1,8-diazabicycloundec-7-ene (abbreviated as DBU) and 1 mmol of N-methylbenzylamine were added to the above system. Stirring was continued for 2 h in the dark. Then, at 1 atm oxygen and lambda ? 420 nm visible light (using a xenon lamp as a light source, a 420 nm filter is used to filter out light having a wavelength of less than 420 nm, The following examples are the same as the light intensity of 1.01 W¡¤cm -2 ) for 3 h under light conditions. The reaction products were qualitatively analyzed and quantified by gas chromatography-mass spectrometry (GC-MS) and gas chromatography (GC). The experiment was recorded as Entry 1.

The synthetic route of 104-11-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; South Central University for Nationalities; Yang Changjun; Jin Juanjuan; Deng Kejian; Zhang Bingguang; (12 pag.)CN108623494; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 7149-75-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7149-75-9, name is 4-Chloro-3-methylaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A solution of the corresponding aniline (0.5 mmol) in dry THF(4 mL/mmol) was treated with Et3N (5.4 mmol) under inert atmosphere.After stirring the mixture for 5 min, the carbamate derivedfrom AmCA-4 (prepared following the described procedure [20])(0.5 mmol) was added dissolved in THF (10 mL/mmol). The resultingmixture was then stirred in the dark at 40-50 C for 24-72 h(TLC monitoring). After this time, CH2Cl2 (15 mL) and HCl 1M were added to the reaction mixture, which was then extracted withCH2Cl2 (2 x 10 mL). The organic layer was washed with brine, and then dried on anhydrous Na2SO4. Removal of volatiles under reduced pressure afforded an oily residue which was subjected to column chromatography on silica-gel (Hexane-EtOAc mixtures as eluent) to afford the desired products with the yields indicated below.

The synthetic route of 4-Chloro-3-methylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Conesa-Milian, Laura; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto; European Journal of Medicinal Chemistry; vol. 162; (2019); p. 781 – 792;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 21711-56-8 as follows. Product Details of 21711-56-8

Under a nitrogen stream, a-1 (20.0 g, 66.85 mmol) synthesized in Preparation Example 1, A-2 (17.40 g, 66.85 mmol) synthesized in Preparation Example 2,Pd (OAc) 2 (1.50 g, 6.69 mmol),NaOtBu (16.06 g, 167.12 mmol) and P (t-Bu) 3 (2.70 g, 13.37 mmol) were placed in 400 ml of xylene and stirred at 150 degree For 24 hours. After completion of the reaction, the mixture was extracted with methylene chloride, concentrated under reduced pressure, and 30.9 g of b-1 was obtained by column chromatography.

According to the analysis of related databases, 21711-56-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DOOSAN CORPORATION; Jo, Hung Sang; KIM, Chung Han; PARK, Ho Chul; LEE, CHANG JUN; SIN, JIN YONG; LEE, JAE HUN; Baek, Young Mi; (18 pag.)KR2015/103949; (2015); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1871-57-4

To a solution of 3-chloro-2-chloromethyl-1-propene (methallyl dichloride, 3.00 g, 24.0 mmol)and propargyl alcohol (8.50 mL, 144 mmol) in an ice bath was added sodium hydride (50%in mineral oil, 7.60 g, 158 mmol) portionwise over 1 h. After removing the ice bath, thereaction solution was stirred for another 1 h and then methanol was added. The resultingsolution was concentrated under reduced pressure. The residue was diluted with ethylacetate, washed with an ice-cooled water and a saturated NaCl solution, dried over MgSO 4 ,filtered, and concentrated under reduced pressure. The resulting material was purified bycolumn chromatography on silica gel (50 mL of the gel bed volume, hexane:ethyl acetate =20:1) to give 6 as colorless transparent oil (3.19 g, 81%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1871-57-4.

Reference:
Article; Matsushita, Takahiko; Tsuchibuchi, Koji; Koyama, Tetsuo; Hatano, Ken; Matsuoka, Koji; Bioorganic and Medicinal Chemistry Letters; vol. 28; 10; (2018); p. 1704 – 1707;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 622-24-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 622-24-2, name is (2-Chloroethyl)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

the reaction bottle to add the material five, six, dimethylformamide, potassium carbonate, the reaction, cooling to 25 , the reaction solution added to the ice water, the quality of ice water as the reaction solution 10 times , Filter, washed, dried material seven. The molar ratio of the substance 5, the substance 6, the potassium carbonate and the dimethyl formamide was 1: 1: 1: 10, and the temperature was raised to 80 C for 4 hours.

The synthetic route of (2-Chloroethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sanxia University; Tan, Xiao; Liu, Sen; Yang, Liting; (20 pag.)CN106333949; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 831-81-2, name is 4-Chlorodiphenylmethane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 831-81-2

General procedure: In a 25 mL pressure tube, ZnBr2 (10 mol %) and a stirring bar were added. After the addition of diphenylmethane (1 mmol), trifluoroacetic acid (0.2 mL) and 1,4-dioxane (2 mL) by syringe, H2O2 (4 mmol; 30% aqueous) was added in one pot to the solution and the final solution was kept at 100 C for 16 h. Then hexadecane (100 mg) and ethyl acetate (3 mL) were injected, a part of solution was taken for GC and GC-MS analysis after properly mixed. All the products are commercially available.

The synthetic route of 831-81-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wu, Xiao-Feng; Tetrahedron Letters; vol. 53; 45; (2012); p. 6123 – 6126;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1996-29-8, COA of Formula: C6H3BrClF

To a stirred solution of l-bromo-4-chloro-2-fluorobenzene (5 g, 23.87 mmol) in tetrahydrofuran (40 niL) cooled to -78 C was added LDA (14.92 niL, 29.8 mmol) dropwise. The reaction mixture was stirred at this temperature for 30 min. then allowed to warm to -20 C and stirred for 30 min. The reaction was then cooled to – 78 C and trimethyl borate (3.47 mL, 31.0 mmol) dissolved in THF (5 mL) was added dropwise. The reaction mixture was warmed to -20C and stirred for 1 h. The reaction mixture was then cooled to -78 C and peracetic acid (16 mL, 84 mmol) as slowly added dropwise. The mixture was allowed to warm to rt and stirred for 12 h. The reaction mixture was again cooled to 0 C and quenched with 5% ammonium chloride The solution was extracted with ethyl acetate (2×50 mL). The combined organic layers were washed with brine (50 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to afford 3-bromo-6-chloro-2-fluorophenol (4.99 g, 18.25 mmol, 76 % crude yield) as ayellow oil. The material was carried forward without further purification.LC/MS (ESI) m/e 225.1 [(M+H)+, calcd for C6H4BrClFO 224.9]; LC/MS retention time (method E): tR = 0.87 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; VRUDHULA, Vivekananda, M.; PAN, Senliang; RAJAMANI, Ramkumar; NARA, Susheel, Jethanand; KARATHOLUVHU, Maheswaran, Sivasamban; MAISHAL, Tarun, Kumar; DITTA, Jonathan, L.; DZIERBA, Carolyn, Diane; BRONSON, Joanne, J.; MACOR, John, E.; WO2015/116060; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51572-93-1, name is O-(2,4-Dichlorobenzyl)hydroxylamine hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C7H8Cl3NO

General procedure: To a solution of 3ae3e (1 mmol) in anhydrous ethanol (10 mL),corresponding O-benzylhydroxylamine hydrochloride (1 mmol)and NaOAc (1.2 mmol) were added and the resulting solution wasstirred at the room temperate for 3 h. The mixture was concentratedand taken in ethyl acetate (20 mL), washed with water(20 mL), saturated sodium chloride solution (20 mL) and dried oversodium sulfate. The resulting solution was concentrated and thepurification of the residue by recrystallization from ethanol yieldedthe desired compounds 4a-4t

The synthetic route of 51572-93-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lv, Xian-Hai; Li, Qing-Shan; Ren, Zi-Li; Chu, Ming-Jie; Sun, Jian; Zhang, Xin; Xing, Man; Zhu, Hai-Liang; Cao, Hai-Qun; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 586 – 593;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics