Author: Jessica.F

Related Products of 6276-54-6,Some common heterocyclic compound, 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 8: 3-Chloropropylamine HCl (6.5 g, 0.05 mol) and sodium azide (10 g, 0.15 mol) were dissolved in 50 mL water. The reaction proceeded at 80 C. for 48 hours. 10 N NaOH (6 mL) was then added, and the product was extracted with ether and concentrated in vacuo. Bulb to bulb distillation (Bp=65-75 C. at 20-22 ton) afforded a clear oil (4 g, 80%). 1H-NMR (500 MHz, CDCl3): delta 3.38 (t, J=6.7 Hz, 2H), 2.81 (t, J=6.8 Hz, 2H), 1.73 (p, J=6.8 Hz, 2H).

The synthetic route of 6276-54-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Rockefeller University; STELLER, Hermann; SANDU, Cristinel; KELKAR, Anshuman; GANGADHAR, Nidhi; US2013/244325; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 367-22-6, name is 4-Chloro-3-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 367-22-6

Step 14: Preparation for N-(4-Chloro-3-fluorophenyl)-5-(tetrahydro-2H-pyran-4-yloxy)-2,3-dihydro-[1,4]dioxino[2,3-f]-quinazolin-10-amine To a solution of 10-Chloro-5-(tetrahydro-2H-pyran-4-yloxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinazoline (0.1 g, 0.3 mmol) in isopropanol (3 mL) was added 4-chloro-3-fluoroaniline (0.06 g, 0.4 mmol). The solution was stirred at 80 C. for 4 hours. After cooling to ambient temperature, the solution was concentrated to obtain a yellow solid which was purified by column chromatography on silicon gel (dichloromethane:methanol=100:1) to obtain a yellow solid (0.07 g, yield=49%). 1H NMR (DMSO-d6, 400 MHz): 10.51 (s, 1H), 8.75 (s, 1H), 7.95-7.92 (m, 1H), 7.65-7.64 (m, 1H), 7.54 (t, 1H, J=8.9 Hz), 7.30 (s, 1H), 4.77 (dd, 1H, J=4.4 Hz), 4.61 (br, 2H), 4.60 (br, 2H), 3.92-3.89 (m, 2H), 3.56-3.50 (m, 2H), 2.10-2.07 (m, 2H), 1.72-1.69 (m, 2H); MS: 432(M+H+).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 367-22-6.

Reference:
Patent; BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED; SHENG, Wang; YANG, Leifu; PAN, Zhiyong; (46 pag.)US2017/355683; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 2533-69-9, These common heterocyclic compound, 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 7 Preparation of 1H-benzoimidazole-2-carboxylic acid[6-(2-methyl-pyridine-3-yloxy)-pyridine-3-yl]-amide 1,2-phenylenediamine (1 g, 9.25 mmol) was dissolved in acetic acid (30 ml), methyltrichloroacetimidate (1.26 ml, 10.18 mmol) was added to the solution at 0 C. and then the mixture was stirred at room temperature. After the reaction was completed, the product was washed, filtered, and dried to obtain 2-trichloromethyl-1H-benzoimidazole.

The synthetic route of 2533-69-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; US2009/258876; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14862-52-3, name is 3,5-Dibromochlorobenzene, A new synthetic method of this compound is introduced below., Safety of 3,5-Dibromochlorobenzene

Sub-1-IV-34 (20.98 g, 52.54 mmol) obtained in the above synthesis was dissolved in THF (220 ml) in a round bottom flask and 1,3-dibromo-5-chlorobenzene (CAS Registry Number: 14862-52-3) (21.31 g, 78.81 mmol), Pd (PPh3) 4 (2.43 g, 2.10 mmol), K2CO3 (21.78 g, 157.62 mmol) and water (110 ml) were added and stirred at 80 C. After the reaction was completed, the reaction mixture was extracted with CH 2 Cl 2 and water. The organic layer was dried over MgSO 4 and concentrated. The resulting compound was purified by silicagel column and recrystallized to obtain 14.59 g (yield: 60%) of the product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Duksan Neolux Co.,Ltd.; So Gi-ho; Cho Hye-min; Lee Yun-seok; Park Hyeong-geun; Park Jong-gwang; Jeong Yeon-seok; Choi Yeon-hui; Lee Jeong-uk; (66 pag.)KR2017/126400; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 16799-05-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16799-05-6, name is 3-Chlorophenethyl Bromide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: TBAB (0.443g, 1.38mmol), phenethyl bromide (0.65mL, 2.50mmol) and 5.0mL of 25% m/m NaOH solution were added to a solution of 10a (0.25g, 1.275mmol) in 15mL of dry DCM. The mixture was stirred at rt for 48h, and then diluted with 20mL of DCM and 20mL of water. The collected organic phase was washed twice with 20mL of brine, dried (Na2SO4), filtered and concentrated under reduced pressure. The residue was purified by chromatography on silica gel, eluting with ethyl acetate, to afford 12b as pale brown solid (0.270g, 70% yield).

The chemical industry reduces the impact on the environment during synthesis 3-Chlorophenethyl Bromide. I believe this compound will play a more active role in future production and life.

Reference:
Article; de Candia, Modesto; Zaetta, Giorgia; Denora, Nunzio; Tricarico, Domenico; Majellaro, Maria; Cellamare, Saverio; Altomare, Cosimo D.; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 288 – 298;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 2732-80-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2732-80-1, name is 2-Bromo-1-chloro-4-methoxybenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

BBr3 (50 ml) was added slowly in drops over 15 minutes to a solution of 2-bromo-l- chloro-4-methoxybenzene (0.448 mol) in CH2Cl2 (600 ml), stirred at -2O0C. The resultant reaction mixture was stirred for 20 minutes at -200C, then it was warmed to room temperature and stirred for one hour at room temperature, yielding 85 g of intermediate (75).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-chloro-4-methoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2009/62990; (2009); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 118754-53-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 118754-53-3 as follows.

Preparation of 2,6-dichloro-4-trifluoromethylbenzaldehyde To a mixture of 65.2 ml of n-butyllithium (1.61M in hexane) and 100 ml of anhydrous ether was added dropwise 29.3 g of 4-bromo-3,5-dichlorobenzotrifluoride (3) in 20 ml of anhydrous ether at -78 C. over a period of 15 minutes, followed by stirring for 20 minutes. Next, 100 ml an anhydrous ether solution of 21.8 ml of N,N-dimethylformamide was added dropwise to the mixture at the same temperature, followed by stirring at -78 C. for 30 minutes and then at 0 C. for 30 minutes. To the reaction mixture was thereafter added 400 ml of aqueous 1N phosphoric acid. The resulting mixture was further stirred for 30 minutes. The reaction mixture was extracted with ether, and the ethereal layers were combined together, washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue obtained was distilled under reduced pressure, giving 26.7 g of the desired compound in the form of a colorless oil (yield 78.3%). bp 114-115 C./19 mmHg 1 H-NMR (CDCl3, TMS, delta ppm): 7.65(s, 2H), 10.47(s, 1H)

According to the analysis of related databases, 118754-53-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Otsuka Kagaku Kabushiki Kaisha; US5739083; (1998); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 108-37-2,Some common heterocyclic compound, 108-37-2, name is 1-Bromo-3-chlorobenzene, molecular formula is C6H4BrCl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To stirred solution of 3-Bromochlorobenzene (0.50 g, 2.61 mmol) and 1- Cyclopentyl-2-propen-1-ol (1.5 eq, 0.49 g, 3. 88 mmol) in anhydrous N-methylpyrrolidinone (3.0 mL), under argon at room temperature, was added sodium bicarbonate (1.2 eq, 0.26 g, 3.10 mmol) followed by dichlorobis (triphenylphosphine) palladium (II) (0.02 eq, 36. 7 mg, 0.05 mmol). The resulting mixture was heated to 140 C in an oil bath and maintained for 4 hours. The resulting reaction mixture was cooled to room temperature and poured into water (50 mL), and extracted with EtOAc (2 X 25 mL). The organics were washed with water (50 mL) and brine (50 mL) then dried over Na2S04, filtered and concentrated. The crude residue was purified by flash chromatography (1% through 10% EtOAc in Hexanes) to yield the intermediate ketone as a slightly yellow oil (0.49 g, 79%). 1H NMR (CDCl3) : 81. 45-1.87 (m, 8H), 2.70-2. 95 (m, 5H), 7.07 (d, J= 7.0 Hz, 1H), 7.10-7. 25 (m, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3-chlorobenzene, its application will become more common.

Reference:
Patent; PFIZER INC.; WO2003/95441; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 64628-73-5,Some common heterocyclic compound, 64628-73-5, name is 3-Chloro-4-(trifluoromethoxy)aniline, molecular formula is C7H5ClF3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-Benzoyl-3-[3-chloro-4-(trifluoromethoxy)phenyl] thiourea To a stirred solution of 3-chloro-4-(trifluoromethoxy)aniline (5.00 g, 23.6 mmol) in acetone (150 mL) under nitrogen was added benzoyl isothiocyanate (3.98 mL, 29.5 mmol). The reaction was heated at 75C for 1.5 h. The cooled reaction mixture was poured into water (400 mL). The resulting precipitate was collected by filtration to give the title compound as a pale orange solid (9.0 g, quantitative yield); m/z = 374.9 (MH)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-4-(trifluoromethoxy)aniline, its application will become more common.

Reference:
Patent; ACTIVE BIOTECH AB; WELLMAR, Ulf; EAST, Stephen; BAINBRIDGE, Marie; MACKINNON, Colin; CARR, James; HARGRAVE, Jonathan; (296 pag.)WO2016/42172; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 33863-76-2, name is 1-Bromo-3-chloro-5-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33863-76-2, Safety of 1-Bromo-3-chloro-5-fluorobenzene

Preparation 32 1-Bromo-3-chloro-5-methoxybenzene Sodium methoxide (2.20 ml of a 4.5M solution in methanol, 10.0 mmol) was added dropwise to a stirred solution of 1-fluoro-3-chloro-5-bromobenzene (1.00 g, 4.77 mmol) in methanol (28 ml) at room temperature under nitrogen. The reaction was heated under reflux for 3 days and cooled to room temperature. The mixture was concentrated under reduced pressure and the resulting yellow oil was dissolved in dichloromethane (30 ml). The resulting solution was washed with water (2*20 ml) dried over magnesium sulphate, filtered and concentrated under reduced pressure. The crude product was purified by flash column chromatography on silica gel eluding with cyclohexane to provide the title compound (302 mg) as a colourless oil. 1H-NMR (400 MHz, CDCl3): delta=3.77 (s, 3H), 6.82 (s, 1H), 6.94 (s, 1H), 7.09 (s, 1H). Microanalysis: Found: C, 37.94; H, 2.75. C7H6BrClO requires C, 37.96; H, 2.73%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-chloro-5-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jones, Lyn Howard; Mowbray, Charles Eric; Price, David Anthony; Selby, Matthew Duncan; Stupple, Paul Anthony; US2003/100554; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics