Author: Jessica.F

Electric Literature of 118-69-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118-69-4, name is 2,6-Dichlorotoluene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a round bottom flask was added 100 g of 2,6-dichlorotoluene, 0.5 g antimony trichloride, 59.6 g of chlorine gas was introduced at 25 C under atmospheric pressure, the reaction temperature was controlled at 25 to 30 C, Chlorine speed of 10g / h, After about 6 hours, the reaction of 2,6-dichlorotoluene was terminated by GC, and chlorine was stopped. 124.1 g of a reaction liquid was obtained, which comprised 85.4% of 2,3,6-trichlorotoluene, 1.9% of 2,4,6-trichlorotoluene, 12.7% of tetrachlorotoluene and impurities. The reaction solution was subjected to distillation to obtain 104.7 g of 2,3,6-trichlorotoluene in a yield of 86.3% GC area content of 98%.

The synthetic route of 2,6-Dichlorotoluene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu Lianhua Technology Co., Ltd.; Lianhua Technology (Yancheng) Co., Ltd.; Fan, Xiaobin; Lin, Xingjun; Xu, Xiaoming; Huang, Chao; Chen, Donghua; Zhou, Shuyong; (8 pag.)CN105601466; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 821-10-3, name is 1,4-Dichlorobut-2-yne, A new synthetic method of this compound is introduced below., SDS of cas: 821-10-3

[0038] The 1 ,4-dichloro-2-butyne 14 of Example 2 is de-halogenated by base promoted elimination of HC1 to produce diacetylene 15. A mixture of 4 M aqueous potassium hydroxide (3 equivalents) and dimethyl sulfoxide (1 mL per 16 mmol potassium hydroxide) is heated to about 70-75 C. 1 ,4-dichloro-2-butyne (1 equivalent) is added slowly to the mixture while bubbling argon through the solution. The volatile product is directed through a series of two gas washing bottles containing dilute aqueous potassium hydroxide followed by two calcium chloride drying tubes and into a vessel containing anhydrous tetrahydrofuran cooled in an ice-calcium chloride bath to yield a tetrahydrofuran solution of diacetylene 15.

The synthetic route of 821-10-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EMPIRE TECHNOLOGY DEVELOPMENT LLC; KLEIN, Josef Peter; WO2015/60862; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 39226-95-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39226-95-4, name is 2,3-Dichlorobenzylamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 20: Preparation of N-(4,5-dihydrothiazol-2-yl)-N-[1-(2,3-dichlorophenyl)-3- methylbut-3-enyl]amine20.1 Preparation of N-(2,3-dichlorobenzyl)-N-(4,5-dihydrothiazol-2-yl)amineA solution of 2-chloroethyl isothiocyanate (3.45 g) in diethyl ether (20 ml) was added dropwise to a solution of 2,3-dichlorobenzylamine (5.00 g) in diethyl ether(80 ml) at 0 0C and the mixture was allowed to warm up to room temperature over 3 h. An aqueous solution of sodium hydroxide (1 M, 100 ml) was then added and the mixure was further stirred for 1 h. After seperation of the phases, the organic phase was washed with water, dried over sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography to yieldN-(2,3-dichlorobenzyl)-N-(4,5-dihydrothiazol-2-yl)amine.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dichlorobenzylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BASF SE; WO2009/115491; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 157590-59-5, name is 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine, A new synthetic method of this compound is introduced below., Formula: C7H6ClF3N2

318 mg (3 MMOL) BRCN are dissolved in 0.6 ml acetonitrile and treated with 6 ML water. To this solution, 575 mg (2.73 MMOL) 5-CHLORO-6-TRIFLUOROMETHYL- benzene-1, 2-diamine, dissolved in 6 ML METHANOL, are added dropwise within 30 min. After 2 hrs of stirring at room temperature, the reaction mixture is concentrated and the water solution extracted 2X with ethyl acetate. The combined organic phases where RE-EXTRACTED 1x with water. The combined water phases where made alkaline (pH=8) with saturated NAHC03-SOLUTION and extracted 2x with ethyl acetate. The combined organic phases where dried, filtered and evaporated. Yield : 611 MG (95 %) 7, red solid

The synthetic route of 157590-59-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; WO2005/4864; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 445-13-6, name is 3-Chloro-4-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., Quality Control of 3-Chloro-4-(trifluoromethyl)aniline

A solution of 4-amino-2-chlorobenzotrifluoride (9.780 g; 50.007 mmol) in MeCN (65 ml) was treated with copper(ll) bromide (1 1.169 g; 50.007 mmol), and the green heterogeneous mixture was heated to 45C. A solution of tert-butyl nitrite (6.53 ml; 55.008 mmol) in MeCN (10 ml) was then added dropwise over 30 min., and the resulting mixture was further stirred at 45C for 2h20. The dark heterogeneous reaction mixture was allowed to cool to rt, and was directly purified by FC (DCM). After concentration to dryness under reduced pressure, the expected product 4-bromo-2-chloro-1-trifluoromethyl-benzene was obtained as a yellow oil (12.82O g; 50%). LC-MS: tR = 1.10 min.; [M+H]+: no ionisation.

The synthetic route of 445-13-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/78291; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 39989-43-0, name is 3,5-Dichlorobenzylamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39989-43-0, category: chlorides-buliding-blocks

A mixture of [(3,5-dichlorophenyl) methyl]amine (100 mg), 2-bromo- 1,1bis (methyloxy)ethane (123 muL) and K2C03 (95 mg) in anhydrous DMF (2 mL) was processed by microwave irradiation at 150C for 10 min (3 cycles). The mixture was allowed to cool to rt, water was added and mixture extracted three times with AcOEt, the organic phases collected, washed with brine, dried and evaporated under vacuum to give a crude which was purified by flash cromathography eluting with CH: AcOEt= 9: 1 to 85:15 to afford the title compound (120 mg) as a colourless oil. MS (ES/+) : m/z=264 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dichlorobenzylamine, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2005/121122; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 6940-78-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6940-78-9 name is 1-Bromo-4-chlorobutane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3.53 g of 1-bromo-4-chlorobutane (20.6 mmol) was dissolved in 50 ml of absolute ethanol, added to a 500 ml round bottom flask,Set 0 C in an ice bath with stirring, with a constant pressure dropping funnel was slowly added dropwise 3.11g50% sodium methanethiolate (22.2mmol) absolute ethanolLiquid, naturally warmed to room temperature, overnight, the total reaction time is not less than 24h. Stop stirring, remove the ethanol by vacuum low temperature cyclization to positiveHexane three consecutive extraction, the extract was dried over anhydrous sodium sulfate, insoluble matter was filtered off. Remove the n-hexane by vacuum evaporation at low temperature to obtain the product2.69 g of a colorless oil with a strong mustard odor and an intermediate content of about 81% as determined by GC-MS. The intermediate yield was about76.3%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-chlorobutane, and friends who are interested can also refer to it.

Reference:
Patent; Taishan Medical School; Li Binglong; Liu Changli; Zhao Shizhen; Qi Yongxiu; Xia Chengcai; Li Furong; Li Ke; Hao Liyong; Guan Xidong; (6 pag.)CN106866478; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51419-59-1, name is p-Tolylmethanesulfonyl chloride, A new synthetic method of this compound is introduced below., Recommanded Product: p-Tolylmethanesulfonyl chloride

6-Amino-1-allyl-3,4-dihydro-2 (1H)-quinolinone was prepared in the same manner as in Steps 1.1, 1.2 and 1.3 of Example 1, except that 3-bromopropene was used instead of 3-iodopropane. 1.01 g (5 mmol) of 6-amino-1-allyl-3,4-dihydro-2 (1H)-quinolinone and 1.23 g (6 mmol) of 4-methyl benzylsulfonyl chloride were added into 30 mL of DMF, and 2.01 g (15 mmol) of potassium carbonate was added as an acid-binding agent. The reaction was maintained at room temperature and stirred for 16 hours. After the reaction was completed, ice water was added, and extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and concentrated. The crude product was subjected to silica gel column chromatography to give 1.36 g of the compound 130925 as a pale yellow solid, with a yield of 73%. 1H NMR (400 MHz, CDCl3): delta 7.22-6.93 (m, 7H), 5.91-5.83 (m, 1H), 5.25-5.13 (dd, 2H), 4.54 (s, 2H), 4.27 (d, 2H), 2.89 (t, 2H), 2.68 (t, 2H), 2.32 (s, 3H) ppm.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES; ZHU, Jiankang; CAO, Minjie; ZHANG, Yulu; LIU, Xue; (56 pag.)US2018/360039; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 19752-55-7

3-(3,5-dichlorophenyl)pyridine Synthesised according to General Procedure 36. A mixture of 1-bromo-3,5-dichloro-benzene (424 mg, 1.88 mmol), 3-pyridineboronic acid pinacol ester (500 mg, 2.44 mmol), aqueous 2M Na2CO3 (1.96 mL, 3.93 mmol) and Pd(PPh3)4 (89 mg, 4 mol percent) in anhydrous toluene (18 mL) was stirred overnight at 80¡ã C. under nitrogen. The reaction was cooled down to room temperature, diluted with water (5 ml) and ethyl acetate (10 ml). The organic phase was separated, dried (Na2SO4), filtered and concentrated under reduced pressure to give a pale yellow oil, which was purified by silica-gel column chromatography to give 3-(3,5-dichlorophenyl)pyridine (481 mg, 74percent) as a white solid. 1H-NMR (400 MHz, CDCl3) delta 8.81 (d, J=2.1 Hz, 1H), 8.65 (dd, J=1.4, 4.8 Hz, 1H), 7.85-7.82 (m, 1H), 7.46 (d, J=1.8 Hz, 2H), 7.41-7.38 (m, 2H). LC/MS (10percent-99percent CH3CN (0.035percent TFA)/H2O (0.05percent TFA)), m/z: M+1 obs=224.3; tR=1.21 min.

The synthetic route of 19752-55-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Stamos, Dean; Martinborough, Esther; Zimmermann, Nicole; Neubert, Timothy; Numa, Mehdi Michel Djamel; Whitney, Tara; Kawatkar, Aarti Sameer; US2009/131440; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53531-69-4, name is (4-Bromophenyl)methanesulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 53531-69-4

Step 3: C-(4-Bromo-phenyl)-N-(3-chloro-phenyl)-methanesulfonamide To a solution of (4-bromo-phenyl)-methanesulfonyl chloride (1.4 g, 5.2 mmol) in DCM (20 mL) at room temperature was added pyridine (1.26 mL, 15.6 mmol) followed by 3-chloroaniline (1.1 mL, 10.4 mmol) and the reaction was stirred at room temperature for 3 hours. 1 M aqueous HCl was added and then extracted with DCM, filtered through a separator, concentrated, dry loaded onto silica and purified by silica gel column chromatography (0-100% DCM in cyclohexane) to give C-(4-bromo-phenyl)-N-(3-chloro-phenyl)-methanesulfonamide (0.61 g, 1.68 mmol). 1H NMR (300 MHz, CDCl3): delta 7.49 (d, 2H), 7.26 (m, 1H), 7.13-7.15 (m, 4H), 6.96-6.98 (m, 1H), 6.31 (s, 1H), 4.31 (s, 2H).

According to the analysis of related databases, 53531-69-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; Fauber, Benjamin; Rene, Olivier; Bodil van Niel, Monique; Ward, Stuart; US2014/163110; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics