Author: Jessica.F

Rhee, Sung W. published the artcileSynthesis of tritium labeled 4P-PDOT, a selective melatonin receptor antagonist, Quality Control of 18791-02-1, the publication is Journal of Labelled Compounds & Radiopharmaceuticals (2000), 43(9), 925-932, database is CAplus.

A selective MT2 melatonin receptor antagonist, 4-phenyl-2-propionamidotetralin (4P-PDOT), was prepared as a tritium-labeled compound with high specific activity and radiochem. purity. Catalytic hydrogenation of a unique vinyl bromo precursor was used to introduce the tritium.

Journal of Labelled Compounds & Radiopharmaceuticals published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Quality Control of 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

He, Hualing published the artcileCatalytic Asymmetric Reduction of α-Trifluoromethylated Imines with Catecholborane by BINOL-Derived Boro-phosphates, HPLC of Formula: 5860-95-7, the publication is Journal of Organic Chemistry (2021), 86(5), 4336-4345, database is CAplus and MEDLINE.

A catalytic enantioselective reduction of α-trifluoromethylated imines by a BINOL-derived boro-phosphate employing catecholborane as hydride source has been developed. This method provides an efficient route to prepare synthetically useful chiral α-trifluoromethylated amines in high yields and with excellent enantioselectivities (up to 98% yield and 96% ee) under mild conditions.

Journal of Organic Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, HPLC of Formula: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ying-Hong published the artcileNovel 12N-substituted matrinanes as potential anti-coxsackievirus agents, COA of Formula: C9H5ClO4S, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(4), 829-833, database is CAplus and MEDLINE.

A series of novel 12N-substituted matrinane derivatives were synthesized and evaluated for their activities against coxsackievirus type B3 (CVB3) taking compound I as the lead. SAR anal. indicated that the introduction of a suitable heteroaromatic ring on the 12N-atom might be beneficial for the activity. Among them, compound II exhibited the highest potency against all CVB serotypes as well as CVA16 with IC₅₀ values ranging from 2.02 μM to 7.41 μM, indicating a broad-spectrum anti-coxsackieviruse effect. Furthermore, compound II demonstrated a good safety profile in vivo. Thus, we consider 12N-substituted matrinanes to be a promising family of anti-coxsackievirus agents, and compound II to be a promising drug candidate in the treatment of various diseases related to coxsackievirus infection.

Bioorganic & Medicinal Chemistry Letters published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, COA of Formula: C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Bin published the artcileBase-mediated tandem sulfonylation and oximation of alkenes in water, HPLC of Formula: 32333-53-2, the publication is Green Chemistry (2017), 19(24), 5794-5799, database is CAplus.

A base-mediated bifunctionalization of alkenes such as ethenyl-benzene, methylene-cyclopentane, 1-hexene, etc. for the synthesis of α-sulfonylethanone oximes RC(=NOH)CH(R¹)SO₂R² (R = Ph, naphthalen-2-yl, (CH₂)₃CH₃, 4-(chloromethyl)phenyl, etc.; RR¹ = -(CH₂)₃-, R¹ = H, Br; R² = 4-methoxyphenyl, thiophen-2-yl, naphthalen-2-yl, CH₃C(O), etc.) was developed in water under metal-free conditions. This reaction features a wide substrate scope and facile starting materials to afford the desired products in high yields.

Green Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C12H10FeO4, HPLC of Formula: 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tan, Fang-Fang published the artcileUtilization of a Hydrogen Source from Renewable Lignocellulosic Biomass for Hydrogenation of Nitroarenes, COA of Formula: C6H3ClFNO2, the publication is ChemCatChem (2019), 11(16), 4189-4195, database is CAplus.

Herein, the utilization of a hydrogen source from renewable lignocellulosic biomass, one of the most abundant renewable sources in nature, for a hydrogenation of nitroarenes was described. The hydrogenation was demonstrated by reduction of nitroarenes to arylamines e.g., I in up to 95% yields. Mechanism studies suggested that the hydrogenation occurred via a hydrogen transformation pathway.

ChemCatChem published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C65H82N2O18S2, COA of Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yanagi, Tomoyuki published the artcileAsymmetric systematic synthesis, structures, and (chir)optical properties of a series of dihetero[8]helicenes, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Chemical Science (2021), 12(8), 2784-2793, database is CAplus and MEDLINE.

A series of dihetero[8]helicenes (P)/(M)/(rac)-I (R = O, S, NH, SO₂) have been systematically synthesized in enantiomerically enriched forms by utilizing the characteristic transformations of the organosulfur functionality. The synthetic route begins with assembling a ternaphthyl II common synthetic intermediate from 2-naphthol and 2,7-bis(phenethylsulfinyl)naphthalene through an extended Pummerer reaction followed by facile multi-gram-scale resolution The subsequent cyclization reactions into dioxa- and dithia[8]helicenes (P)/(M)/(rac)-I take place with excellent axial-to-helical chirality conversion. Dithia[8]helicenes (P)/(M)/(rac)-III are further transformed into the nitrogen (P)/(M)/(rac)-I and the carbon analogs (P)/(M)/(rac)-IV and (P)/(M)/(rac)-V by replacing the two endocyclic sulfur atoms via S_NAr-based skeletal reconstruction. The efficient systematic synthesis has enabled comprehensive evaluation of phys. properties, which has clarified the effect of the endocyclic atoms on their structures and (chir)optical properties as well as the unexpected conformational stability of the common helical framework.

Chemical Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15NO, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pasha, Maira published the artcileCatalytic enantioselective oxa-hetero-Diels-Alder reactions of enones with aryl trifluoromethyl ketones: synthesis of tetrahydropyranones, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Heterocycles (2021), 103(1), 198-204, database is CAplus.

Diastereo- and enantioselective oxa-hetero-Diels-Alder reactions of enones with aryl trifluoromethyl ketones that afford tetrahydropyranone derivatives catalyzed by an amine-based catalyst system are reported. The major diastereomers of the tetrahydropyranone products obtained in these reactions had the relative stereochem. different from that of the previously synthesized tetrahydropyranone derivatives

Heterocycles published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pasha, Maira published the artcileOrganocatalytic diastereo- and enantioselective oxa-hetero-Diels-Alder reactions of enones with aryl trifluoromethyl ketones for the synthesis of trifluoromethyl-substituted tetrahydropyrans, Quality Control of 21286-54-4, the publication is Organic & Biomolecular Chemistry (2021), 19(42), 9242-9250, database is CAplus and MEDLINE.

Here diastereo- and enantioselective oxa-hetero-Diels-Alder reactions catalyzed by amine-based catalyst systems that afford trifluoromethyl-substituted tetrahydropyranones was reported. Catalyst systems and conditions suitable for the reactions to provide the desired diastereomer products with high enantioselectivities were identified, and various trifluoromethyl-substituted tetrahydropyranones were synthesized with high diastereo- and enantioselectivities. Mechanistic investigation suggested that the reactions involve a [4 + 2] cycloaddition pathway, in which the enamine of the enone acts as the diene and the ketone carbonyl group of the aryl trifluoromethyl ketone acts as the dienophile. In this study, tetrahydropyran derivatives with the desired stereochem. that are difficult to synthesize by previously reported methods were concisely obtained, and the range of tetrahydropyran derivatives that can be synthesized was expanded.

Organic & Biomolecular Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Quality Control of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Reeves, Jonathan T. published the artcileDevelopment of an Enantioselective Hydrogenation Route to (S)-1-(2-(Methylsulfonyl)pyridin-4-yl)propan-1-amine, COA of Formula: C6H4ClNO2, the publication is Organic Process Research & Development (2014), 18(7), 904-911, database is CAplus.

A highly enantioselective enamide hydrogenation route to the title amine was developed. Highlights of the synthesis include an efficient two-step synthesis of a 2-sulfonyl 4-pyridyl Et ketone, a simple enamide synthesis by direct condensation of propionamide with a ketone, catalytic asym. enamide hydrogenation employing the inhouse-developed ligand MeO-BIBOP, and a mild epimerization-free deprotection of a propionamide using Koenig’s procedure.

Organic Process Research & Development published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, COA of Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Junji published the artcileSoft mimic gear-shift with a multi-stimulus modified diarylethene, Formula: C15H14Cl2S2, the publication is Journal of Materials Chemistry (2009), 19(32), 5726-5729, database is CAplus.

A novel gated photochromic compound 1,8-naphthalimidepiperazine-tethered dithienylethene (Nap-Pip-DTE) was prepared to mimic a soft gear-shift based on alternative UV/Vis irradiation, protonation/deprotonation and copper(II) ion complexation/dissociation The fluorescence and absorption spectra were used as output signals. Copper(II) ion was introduced to mimic the parking (P) state by complexation with two intramol. piperazine moieties of Nap-Pip-DTE, transforming diarylethene moieties into the photoinactive parallel form.

Journal of Materials Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C17H18N3NaO3S, Formula: C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics