Author: Jessica.F

Van Lerberghe, K. published the artcileThe improved silane method for the preparation of free paint and varnish films. 3, Application of Dichloro(hexyl)(methyl)silane, the publication is Double Liaison – Chimie des Peintures (1978), 339-45, database is CAplus.

The properties and utility of substituted silanes in the preparation of free films of coating materials by coating glass plates with silanes prior to application of the coating are described. The use of Me₂SiCl₂ [75-78-5] gave excellent free films from coating solutions, while EtSiMeCl₂ [4525-44-4] and Et₂SiCl₂ [1719-53-5] gave films from coating emulsions.

Double Liaison – Chimie des Peintures published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C11H14O4, Application of Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Van Lerberghe, K. published the artcileThe improved silane method for the preparation of free paint and varnish films. 3, Quality Control of 14799-93-0, the publication is Double Liaison – Chimie des Peintures (1978), 339-45, database is CAplus.

The properties and utility of substituted silanes in the preparation of free films of coating materials by coating glass plates with silanes prior to application of the coating are described. The use of Me₂SiCl₂ [75-78-5] gave excellent free films from coating solutions, while EtSiMeCl₂ [4525-44-4] and Et₂SiCl₂ [1719-53-5] gave films from coating emulsions.

Double Liaison – Chimie des Peintures published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C4H6O3, Quality Control of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Smidt, Hauke published the artcileTranscriptional regulation of the cpr gene cluster in ortho-chlorophenol-respiring Desulfitobacterium dehalogenans, COA of Formula: C8H7ClO3, the publication is Journal of Bacteriology (2000), 182(20), 5683-5691, database is CAplus and MEDLINE.

To characterize the expression and possible regulation of reductive dehalogenation in halorespiring bacteria, a 11.5-kb genomic fragment containing the o-chlorophenol reductive dehalogenase-encoding cprBA genes of the gram-pos. bacterium Desulfitobacterium dehalogenans was subjected to detailed mol. characterization. Sequence anal. revealed the presence of eight designated genes with the order cprTKZEBACD and with the same polarity except for cprT. The deduced cprC and cprK gene products belong to the NirI/NosR and CRP-FNR families of transcription regulatory proteins, resp. CprD and CprE are predicted to be mol. chaperones of the GroEL type, whereas cprT may encode a homolog of the trigger factor folding catalysts. Northern blot anal., reverse transcriptase PCR, and primer extension anal. were used to elucidate the transcriptional organization and regulation of the cpr gene cluster. Results indicated halorespiration-specific transcriptional induction of the monocistronic cprT gene and the biscistronic cprBA and cprZE genes. Occasional read-through at cprC gives rise to a tetracistronic cprBACD transcript. Transcription of cprBA was induced 15-fold upon addition of the o-chlorophenolic substrate 3-chloro-4-hydroxyphenylacetic acid within 30 min with concomitant induction of dehalogenation activity. Putative regulatory protein binding motifs that to some extent resemble the FNR box were identified in the cprT-cprK and cprK-cprZ intergenic regions and the promoter at cprB, suggesting a role for FNR-like CprK in the control of expression of the cprTKZEBACD genes.

Journal of Bacteriology published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C14H10O4, COA of Formula: C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Spielmann, Kim published the artcileDiastereoselective Palladium-Catalyzed (3 + 2)-Cycloadditions from Cyclic Imines and Vinyl Aziridines, Computed Properties of 7080-50-4, the publication is Organic Letters (2018), 20(5), 1444-1447, database is CAplus and MEDLINE.

The synthesis of fused imidazolidines, e.g., I (x-ray single crystal structure shown), via two N-C bond-forming sequences has been developed. The transformation goes through a (3 + 2)-cycloaddition reaction in the presence of catalytic amounts of palladium by combining several vinyl aziridines and cyclic N-sulfonyl imines. Interestingly, the use of LiCl as additive allowed the improvement of diastereoselectivities when less encumbered substrates were used. The imidazolidine derivatives that bear aminal cores are isolated in high yields (15 examples, up to 96% yield) and diastereoselectivities (up to >20:1).

Organic Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C8H19NO2, Computed Properties of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Van Gestel, Tim published the artcileSurface modification of γ-Al₂O₃/TiO₂ multilayer membranes for applications in non-polar organic solvents, Formula: C9H20Cl2Si, the publication is Journal of Membrane Science (2003), 224(1-2), 3-10, database is CAplus.

This paper reports the surface modification of hydrophilic γ-Al₂O₃/anatase-TiO₂ multilayer membranes by a silane coupling treatment, to obtain nanofiltration (NF) membranes applicable in non-polar solvents. Special care was given to optimization of the pore structure of the anatase top layer (microporous-mesoporous) and selection of the reaction medium (Et acetate) and silane coupling reagent ((CH₃)₂SiCl₂, C1 silane; C₈H₁₇CH₃SiCl₂, C8 silane). Hexane and water permeability were studied before and after silane treatment as an indication of the effect of the modification. No hexane permeability was obtained before modification. For microporous membranes fired at 300°C, the internal pore structure remained hydrophilic upon silane treatment, as evidenced by the fact that the hexane permeability remained zero. On the contrary, the more open membrane structure with mesopores obtained by firing at temperatures higher than 400°C, could be modified by a silane coupling reaction at the internal pore structure. The ratio of permeability, hexane/water, was altered from 0/1 for a firing at 300°C and a C1 silane treatment to 1/0 for a firing at 500°C and a C8 silane treatment. Standard PEG-retention measurements in water showed that the membranes fired at 400 and 450°C and modified with a C8 and C1 silane, resp., have pore sizes corresponding to those of nanofiltration (NF) membranes. These membranes were characterized by a mol. weight cut-off (MWCO) of 410 and a hexane permeability of 3 L.h^-1.m^-2.bar^-1 (400-C8) and a MWCO of 650 and a hexane permeability of 5 L.h^-1.m^-2.bar^-1 (450-C1).

Journal of Membrane Science published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C4H6BrFO2, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Frambach, Sanne J. C. M. published the artcileEffects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice, Computed Properties of 637-07-0, the publication is Biochimica et Biophysica Acta, Molecular Basis of Disease (2020), 1866(6), 165727, database is CAplus and MEDLINE.

Mitochondrial complex I (CI), the first multiprotein enzyme complex of the OXPHOS system, executes a major role in cellular ATP generation. Consequently, dysfunction of this complex has been linked to inherited metabolic disorders, including Leigh disease (LD), an often fatal disease in early life. Development of clin. effective treatments for LD remains challenging due to the complex pathophysiol. nature. Treatment with the peroxisome proliferation-activated receptor (PPAR) agonist bezafibrate improved disease phenotype in several mitochondrial disease mouse models mediated via enhanced mitochondrial biogenesis and fatty acid β-oxidation However, the therapeutic potential of this mixed PPAR (α, δ/β, γ) agonist is severely hampered by hepatotoxicity, which is possibly caused by activation of PPARγ. Here, we aimed to investigate the effects of the PPARα-specific fibrate clofibrate in mitochondrial CI-deficient (Ndufs4^-/-) mice. Clofibrate increased lifespan and motor function of Ndufs4^-/- mice, while only marginal hepatotoxic effects were observed Due to the complex clin. and cellular phenotype of CI-deficiency, we also aimed to investigate the therapeutic potential of clofibrate combined with the redox modulator KH176. As described previously, single treatment with KH176 was beneficial, however, combining clofibrate with KH176 did not result in an additive effect on disease phenotype in Ndufs4^-/- mice. Overall, both drugs have promising, but independent and nonadditive, properties for the pharmacol. treatment of CI-deficiency-related mitochondrial diseases.

Biochimica et Biophysica Acta, Molecular Basis of Disease published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Computed Properties of 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Campagnol, Nicolo published the artcileOn the electrochemical deposition of metal-organic frameworks, Product Details of C6H4ClNO2, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2016), 4(10), 3914-3925, database is CAplus.

The electrochem. deposition of Metal-Organic Frameworks (MOFs) is an interesting technique to synthesize adherent, microporous layers on top of conductive substrates. The technique can be subdivided in two approaches: anodic and cathodic deposition. While the mechanism of the cathodic approach has already been well studied, at least for MOF-5 not much is known about the anodic approach. A four-step mechanism is proposed to better understand the anodic deposition, and the same MOF used for the study, HKUST-1, is also deposited cathodically to compare the two approaches. This study focuses on how nucleation starts and proceeds, on the influence of the potential applied, the stresses in the growing layers, and the origin of defects like delamination and MOF detachment. The study is followed by critical considerations on the methods and on the technique, together with suggestions and guidelines to synthesize new MOF layers.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Product Details of C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Grytsai, Oleksandr published the artcileSynthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds, Synthetic Route of 3696-23-9, the publication is Bioorganic Chemistry (2020), 104271, database is CAplus and MEDLINE.

Two series of compounds I (R = H, 2-Cl, 3-Br, etc.; X = CH or N) carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivs I (X = N). The biol. results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series I (R = 3-Br; X = CH or N) on several cell lines tested. Moreover, results point out an antiangiogenic activity of these compds I. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.

Bioorganic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vinogradova, L. E. published the artcileProtection of textiles against biodamage, Application In Synthesis of 38146-42-8, the publication is Tekstil’naya Promyshlennost (Moscow, Russian Federation) (1992), 30, database is CAplus.

The protective properties of biocide-impregnated cotton textile packaging were tested during storage of various bleached or dyed cotton textiles under normal conditions and under increased humidity (80-90%) and temperature (20-25°). All the biocides (Ampholan, Katamin AB, Metacid, Decamethoxine, alkyltrimethylammonium chlorides) were effective in normal conditions, but Decamethoxine, alkyltrimethylammonium chlorides failed in textile protection in the humid atm. The best results were obtained with Katamin AB and Metacid.

Tekstil’naya Promyshlennost (Moscow, Russian Federation) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C13H15NO6S, Application In Synthesis of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Epshtein, G. Yu. published the artcileHaloalkyl sulfides. V. Reaction of alkylene sulfides with alkanesulfenyl chlorides and alkyl polythiochlorides, COA of Formula: C4H8Cl2S2, the publication is Zhurnal Obshchei Khimii (1964), 34(7), 2347-9, database is CAplus.

cf. CA 61, 8178c. Addition of RSCl to the appropriate alkylene sulfide in CCl₄ with cooling gave on distillation the indicated disulfides. Ethylene sulfide (I) and ClCH₂CH₂SCl gave (SCH₂CH₂Cl)₂; propylene sulfide (II) gave ClCH₂CH₂SSCH₂CHMeCl; isobutylene sulfide gave ClCH₂CH₂SSCMe₂CH₂Cl (III); I and BrCH₂CH₂SCl gave ClCH₂CH₂SSCH₂CH₂Br, b₄ 129-30°, d₁₉ 1.5683, n¹⁹_D 1.5897; 3-chloro-1,2-propylene sulfide and ClCH₂CH₂SCl gave ClCH₂CH₂SSCH₂CHClCH₂Cl, b₅ 151°, d₂₀ 1.4122, n²⁰_D 1.5752; II and ClSCH₂CHMeBr gave MeCHClCH₂SSCH₂CHMeBr, b₂ 127°, d₁₇ 1.4687, n¹⁷_D 1.5665; II and CCl₃SCl gave CCl₃SSCH₂CHMeCl, b₂ 122°, d₁₈ 1.4726, n¹⁸_D 1.5616; II and MeCHClCH₂SSCl gave (CHMeClCH₂S)₂S, b_1.5 126°, d₁₅ 1.2542, n¹⁵_D 1.5492; I similarly gave ClCH₂CH₂SSSCH₂CHMeCl, b_2.5 125°, d₁₆ 1.3000, n¹⁶_D 1.5634; II and CHMeClCH₂SSSCl gave (MeCHClCH₂SS)₂, undistillable, d₁₇ 1.3560, n¹⁷_D 1.6120; I and CHMeBrCH₂SCl gave ClCH₂CH₂SSCH₂CHMeBr, b_2.5 124°, d₁₇ 1.5462, n¹⁷_D 1.5808; I and CCl₃SCl gave CCl₃SSCH₂CH₂Cl, b₄ 115°, d₁₆ 1.4962, n¹⁶_D 1.4962; II and CHMeClCH₂SCl gave (MeCHClCH₂S)₂, b_2.5 118-26°, d₁₅ 1.2405, n¹⁵_D 1.5408; CHMeClCH₂SCl with 3-chloro-1,2-propylene sulfide gave CHMeClCH₂SSCH₂CHClCH₂Cl, b₁ 128°, d₂₁ 1.3574, n²¹_D 1.5625; isobutylene sulfide gave CHMeClCH₂SSCMe₂CH₂Cl, b_1.5 110°, d₁₆ 1.2153, n¹⁶_D 1.5412. III b_1.5 106-8°, d₁₅ 1.2724, n¹⁵_D 1.5558.

Zhurnal Obshchei Khimii published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, COA of Formula: C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics