Author: Jessica.F

Related Products of 626-43-7,Some common heterocyclic compound, 626-43-7, name is 3,5-Dichloroaniline, molecular formula is C6H5Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Anhydrous TFA (3e5 drops) was added into appropriatelysubstituted aniline (10 mmol) and then heated to 100 C. To thismixture was added 3mL of ethyl acrylate (EA) within 10min, andthe mixture was stirred at 100 C for 24 h. After this period the EAwas removed under vacuum. The resulted residue was purified bysilica gel chromatography to yield compound 6.

The synthetic route of 626-43-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Qi; Shi, Wei-Kang; Ren, Shen-Zhen; Ni, Wei-Wei; Li, Wei-Yi; Chen, Hui-Min; Liu, Pei; Yuan, Jing; He, Xiao-Su; Liu, Jia-Jia; Cao, Peng; Yang, Pu-Zhen; Xiao, Zhu-Ping; Zhu, Hai-Liang; European Journal of Medicinal Chemistry; vol. 156; (2018); p. 126 – 136;,
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Reference of 363-51-9, These common heterocyclic compound, 363-51-9, name is 2-Chloro-6-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2-chloro-6-fluoroaniline (1.5 g, 10.3 mmol), pyridine (1.0 mL, 12.4 mmol), and isobutyric anhydride (2.0 mL, 12.1 mmol) was purged with nitrogen and irradiated in a microwave reactor at 150 C. for 2 hrs. After cooling to r.t., water was added and the mixture was stirred until a solid precipitate formed. The resulting solid was then collected by filtration, washed with water, and air dried to afford N-(2-chloro-6-fluorophenyl)isobutyramide in quantitative yield as an off-white solid. The crude product obtained was used directly in the next step without further purification. LCMS calculated for C10H12ClFNO (M+H)-: m/z=216.1; Found 216.1.

Statistics shows that 2-Chloro-6-fluoroaniline is playing an increasingly important role. we look forward to future research findings about 363-51-9.

Reference:
Patent; Incyte Corporation; Hummel, Joshua; Vechorkin, Oleg; Sokolsky, Alexander; Ye, Qinda; Liu, Kai; Yao, Wenqing; (60 pag.)US2020/48241; (2020); A1;,
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Adding a certain compound to certain chemical reactions, such as: 62593-17-3, name is 2,4-Dichloro-6-(trifluoromethyl)aniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62593-17-3, COA of Formula: C7H4Cl2F3N

A.2.10.1 Synthesis of 2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester To a suspension of CuCI2 (3.0 mmol) in 30 mL CH3CN was added tBu-nitrite (4.1 mmol) followed by dropwise addition of 1 ,1 -dichloroethylen (39.1 mmol). A solution of 2,4- dichloro-6-trifluoromethylaniline (2.2 mmol) in 2 mL CH3CN was slowly added. After stirring at RT overnight, the reaction was quenched with 25percent aqueous HCI solution and extracted 3 times with EtOAc. The combined organic layers were dried over MgS04. After removal of the solvent the crude was redissolved in 3 mL MeOH. After addition of 2.4 mL of a 30percent solution of NaOMe in MeOH the mixture was refluxed for 5 h. Then, 1.8 mL concentrated H2S04 solution was added at RT and the mixture was heated to reflux for 1 h. After concentrating in vacuo the resulting solid was partitionned between water and DCM. The water phase was extracted 3 times with DCM. The combined organic layers were dried over MgS04. Purification with CC using Hept/EtOAc (10/1 ) gives the desired product as yellowish oil. LC-MS (A): tR = 0.93 min; 1H NMR ((CD3)2SO) delta: 8.1 1 (s, 1 H), 7.88 (s, 1 H), 3.97 (s, 2H), 3.65 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dichloro-6-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; KIMMERLIN, Thierry; RENNEBERG, Dorte; STAMM, Simon; WO2013/108227; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 106131-61-7, name is 3,6-Dichloro-1,2,4,5-tetrazine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106131-61-7, COA of Formula: C2Cl2N4

General procedure: In a 100 mL round bottom flask, was introduced the diol(0.66 mmol), s-collidine (0.79 mmol) and 20 mL of dry dichloromethane and the mixture was stirred at room temperature. 3,6-dichloro-s-tetrazine 1 (0.66 mmol) was dissolved in dry dichloromethane and added dropwise in the flask. After 2 h the reaction is complete (TLC) and the solvent was removed under reduced pressure. The crude residue was purified by column chromatography on silica gel (eluent from petroleum ether/ethyl acetate 7/3 to pure ethyl acetate).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,6-Dichloro-1,2,4,5-tetrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Guermazi, Refka; Royer, Lorna; Galmiche, Laurent; Clavier, Gilles; Audebert, Pierre; Hedhli, Ahmed; Journal of Fluorescence; vol. 26; 4; (2016); p. 1349 – 1356;,
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These common heterocyclic compound, 918538-05-3, name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H3Cl2N3

116A. Preparation of 7-bromo-2,4-dichloropyrrolo[1,2-f][1,2,4]triazine A slurry of N-bromosuccinimide (4.17 g, 23.40 mmol) in 10 mL of acetonitrile was added to a cooled (0 C.) solution of 2,4-dichloropyrrolo[1,2-f][1,2,4]triazine (4 g, 21.27 mmol) in acetonitrile over 1 h. The reaction mixture was allowed to come to room temperature and stirred for an additional 16 hr to get a solution. The solvents were evaporated to get a solid. To this residue was added dichloromethane to dissolve most of the solids and the resulting solution was loaded onto 250 gm of silica in a 350 mL coarse frit funnel (preequilibrated with 5% EtOAc in hexanes). The silica gel was washed with 5% to 50% EtOAC in hexanes. The fractions were collected and evaporated to obtain 7-bromo-2,4-dichloropyrrolo[1,2-f][1,2,4]triazine (5.29 g, 93% pure) as crystals contaminated with ~7% of the 5-bromo isomer. The mixture as such was carried to the next step without further purification. MS (ESI) m/z 266.08 (M+H).

The synthetic route of 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bristol-Myers Squibb Company; US2008/45496; (2008); A1;,
Chloride – Wikipedia,
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Synthetic Route of 6276-54-6, The chemical industry reduces the impact on the environment during synthesis 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, I believe this compound will play a more active role in future production and life.

3-Chloropropylamine hydrochloride (1.85g, 14.2mmol) is suspended in toluene (20mL). 1.0mL of 37w% formaldehyde solution (13.4mmol) is added, then once the solids have dissolved KOH (930mg, 14.1mmol based on 85% purity) is also added. The mixture is stirred for 5h. The clear toluene phase is taken from the white paste and filtered through MgSO4. The solids are extracted with a further 1mL of toluene. The combined solutions are pumped down and the residue is dried under high vacuum for 1hr to leave a colourless oil (1.298g, 4.1mmol, 93%) which turns cloudy within a few hours. 1H NMR (m-PhF set to 7.072): delta=3.39 (6H, t, J=6.4, -CH2Cl), 3.12 (6H, s, NCH2N), 2.38 (6H, t, J=6.6, TACCH2-), 1.64 (6H, quintet, J=6.5, -CH2CH2Cl). 13C NMR – 1H-coupled, (m-PhF set to 130.476): delta=74.6 (t of quintets, J=143/4.6, NCH2N), 49.6 (t, J=133, TAC-CH2-), 43.3 (t of quintets, J=151/4.2, -CH2Cl), 31.1 (t of t, J=128/2.8, -CH2CH2Cl).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloropropan-1-amine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Koehn, Randolf D.; Coxon, Alexander G.N.; Hawkins, Christopher R.; Smith, David; Mihan, Shahram; Schuhen, Katrin; Schiendorfer, Michael; Kociok-Koehn, Gabriele; Polyhedron; vol. 84; (2014); p. 3 – 13;,
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Electric Literature of 918538-05-3,Some common heterocyclic compound, 918538-05-3, name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, molecular formula is C6H3Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

191A. 2-Chloro-N-(5-cyclobutyl-1H-pyrazol-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine 5-Cyclobutyl-1H-pyrazol-3-amine (see J. Med. Chem., 2001, 44(26), 4628-4660) (89 mg, 0.65 mmol) is dissolved in isopropyl alcohol (2-3 mL), N,N-diisopropylethylamine (174 muL, 1.0 mmol) is then added, followed by the compound from 1B (85 mg, 0.45 mmol). The reaction mixture is then stirred at RT for 22 h and the solid precipitate is collected by filtration, washed with a few mL of cold isopropyl alcohol, and dried in vacuo to give 106 mg (81.5%) of the title compound as a solid: MS: 289, 291 (M+H)+, LC/MS ret. t=2.02 min.; HPLC (Method D) ret. time 15.35 min.

The synthetic route of 918538-05-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bristol-Myers Squibb Company; US2008/9497; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67279-24-7, name is 1,4-Dichloro-5,6,7,8-tetrahydrophthalazine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 67279-24-7

To a solution of 1,4-dichloro-5,6,7,8-tetrahydro-phthalazine (compound 41, 0.50 g, 2.46 mmol) in THF (5 mL) are added 4-fluoro-benzyl zincchloride (0.5M in THF) (6.40 mL, 3.20 mmol) and palladium tetrakis triphenylphosphine (0.36 g, 0.31 mmol). The mixture is degassed and stirred at 50 C. overnight. Then the reaction mixture is cooled down to room temperature, sat. NaHCO3 and water are added and the mixture is extracted with EtOAc. The combined organic layers are washed with brine, dried over Na2SO4, filtered and concentrated down. The crude product is purified by chromatography (EtOAc/heptane: 10% 40%) to give 1-chloro-4-(4-fluoro-benzyl)-5,6,7,8-tetrahydro-phthalazine (46) (0.51 g, 30%).MS (m/z, MH+) meas. 277.11.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 67279-24-7.

Reference:
Patent; Novartis AG; US2010/41663; (2010); A1;,
Chloride – Wikipedia,
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Electric Literature of 106131-61-7,Some common heterocyclic compound, 106131-61-7, name is 3,6-Dichloro-1,2,4,5-tetrazine, molecular formula is C2Cl2N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,2,4-Triazole (3:5 g 50 mmol) was dissolved in 200 mL acetone, and 20 mL (12 mmol) of a 0:6M solution of 3,6-dichloro-tetrazine in acetonitrile was added. The solution was refluxed for 20 h. After cooling the resulting precipitate was washed with water and acetone. 2:1 g (9:9 mmol,83%) of (7) was isolated as an orange powder. – Elemental analysis (C6H4N10, 212.21) exp. (calcd.) in %: C33.43 (33.34), N 64.33 (64.80), H 1.87 (1.87). – DSC(5 C min1): Tdec:: 245 C (onset). – 1H NMR ([D6]DMSO,25 C, ppm): d =8.34 (s, 1H, C-H), 9.46 (s, 1H, C-H). -13C NMR ([D6]DMSO, 25 C, ppm): d =144.9 (1C), 147.2(1C), 154.2 (1C). – MS ((+)-DEI): m=z=216 [M]+ (50), 94(100), 67 (92). – Raman: n (cm-1)= 3139 (8), 3124 (12),1912 (2), 1557 (2), 1511 (63), 1483 (100), 1426 (4), 1379(21), 1336 (2), 1293 (2), 1264 (12), 1135 (19), 980 (43), 947(5), 813 (20), 662 (2). – IR (25 C, ATR): n (cm-1) = 3135(w), 3120 (w), 1813 (vw), 1755 (vw), 1551 (vw), 1514 (s),1480 (vs), 1384 (m), 1365 (m), 1337 (w), 1293 (vs), 1266 (m), 1196 (s), 1170 (vw), 1155 (s), 1116 (s), 1112 (s), 1054(s), 976 (vs), 953 (m), 939 (m), 910 (m), 880 (m), 672 (vs).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,6-Dichloro-1,2,4,5-tetrazine, its application will become more common.

Reference:
Article; Klapoetke, Thomas M.; Preimesser, Andreas; Stierstorfer, Joerg; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 68; 12; (2013); p. 1310 – 1320;,
Chloride – Wikipedia,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75717-77-0 as follows. Product Details of 75717-77-0

General procedure: A solution of 3-azido-1-tert-butyl-3-nitro-azetidine 5 (995 mg, 5 mmol) and substituted acetylene (c-k) (5.25 mmol.) in THF (40 ml) was treated at room temperature by adding a solution of ascorbic acid (440 mg, 2.5 mmol) in water (20 ml), followed by a solution of CuSO4¡¤5H2O (188 mg, 0.75 mmol) in water (10 ml). The reaction mixture was stirred for 2-6 h at room temperature. After the reaction was complete according to TLC, the mixture was diluted with water (20 ml) and extracted with CH2Cl2 (4¡Á20 ml). The organic layer was dried over Na2SO4, the solvent was removed at reduced pressure, and the residue was purified by flash chromatography (EtOAc/n-hexane, 2:3) to give the desired products 6c-k as colorless solids.

According to the analysis of related databases, 75717-77-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Dubovis, Mikhail V.; Rudakov, Gennady F.; Kulagin, Alexander S.; Tsarkova, Kseniya V.; Popkov, Sergey V.; Goloveshkin, Alexander S.; Cherkaev, Georgiy V.; Tetrahedron; vol. 74; 6; (2018); p. 672 – 683;,
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