Author: Jessica.F

Arenesulfonic acid derivatives. XI. Synthesis of sulfonamides, hydrazides, and ureas containing a benzofuran moiety was written by Kaldrikyan, M. A.;Geboyan, V. A.;Aroyan, A. A.;Stepanyan, N. O.;Sapondzyan, L. G.;Sarkisyan, L. M.. And the article was included in Armyanskii Khimicheskii Zhurnal in 1980.Synthetic Route of C10H13ClO3S This article mentions the following:

Sixteen amides I (R, R¹ = Me, Et, Pr, Bu) were obtained in 61-91% yield by reaction of p-ROC₆H₄SO₂Cl (II) with the corresponding benzofuranylalkylamine. Treatment of 2-benzofurancarboxylic hydrazide with II gave 72-80% III, which could also be obtained using the benzofurancarbonyl chloride and p-ROC₆H₄SO₂NHNH₂. Eight IV (R = Me, Et, Pr, Bu; R¹ = Me, Et) were obtained in 45-74% yield by reaction of p-ROC₆H₄SO₂NHCO₂Et with the corresponding benzofuranylalkylamine. The hypoglycemic and anticonvulsive properties of I, III and IV were determined; none exhibited anticonvulsive properties and I (R = R¹ = Pr) reduced blood glucose content by 20% at 250 mg/kg. All the remaining compounds exhibited hyperglycemic activity. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Synthetic Route of C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of biaryls via intramolecular free radical ipso-substitution reactions was written by Ujjainwalla, Feroze;da Mata, Maria Lucilia E. N.;Pennell, Andrew M. K.;Escolano, Carmen;Motherwell, William B.;Vazquez, Santiago. And the article was included in Tetrahedron in 2015.Application of 63624-28-2 This article mentions the following:

A variety of functionalized biaryls and heterobiaryls are prepared by intramol. free radical [1,5]-ipso-substitution using sulfonamide and sulfonate derived tethering chains. The overall efficiency of the process is determined by appropriately positioned substituents on the aromatic acceptor ring. The extension of the process to benzylic sulfonates and their corresponding N-methylsulfonamide alternatives as substrates in potential [1,6]-ipso-substitution reactions leads mainly to the alternative [1,7] addition products. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Application of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iodide-Catalyzed Carbonylation-Benzylation of Benzyl Chlorides with Potassium Aryltrifluoroborates under Ambient Pressure of Carbon Monoxide was written by Han, Wei;Chen, Junjie;Jin, Fengli;Yuan, Xiaorong. And the article was included in Synlett in 2018.Electric Literature of C8H9Cl This article mentions the following:

The novel transition-metal free synthesis of a wide range of 1,2,3-triarylpropan-1-ones R¹CH₂CHR¹C(O)R² (R¹ = Ph, 3,4-Cl₂C₆H₃, 3-MeOC₆H₄, etc.; R² = Ph, 4-FC₆H₄, 2-naphthyl, etc.) in high yields was developed via tetrabutylammonium iodide-catalyzed carbonylation-benzylation of unactivated benzyl chlorides R¹CH₂Cl with potassium aryltrifluoroborates R²BF₃K using CO gas under ambient pressure. This protocol provides an inexpensive and operationally simple method for synthesis of 1,2,3-triarylpropan-1-ones and represented a significant improvement over the traditional palladium-catalyzed carbonylation. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Electric Literature of C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The pH sensitive fluorescence SiO₂@TEuTTA/CS composite films and inks for anti-counterfeiting was written by Li, Le;Xi, Peng;Li, Quan;Wang, Xiaoqing;Cheng, Bowen. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2022.Application In Synthesis of Trimesoylchloride This article mentions the following:

Functional chitosan (CS) composite films have wide application prospects in many fields. Herein, the lanthanide inorganic-organic hybrid nanospheres with an average diameter of 252 nm (SiO₂@TEuTTA) were synthesized by surface modification of silica nanospheres. And the SiO₂@TEuTTA was used as luminescent materials and SiO₂@TEuTTA/CS composite films were prepared by a simple solution casting method. Subsequently, the compositions and structure, fluorescence and mech. properties of the SiO₂@TEuTTA/CS composite films were characterized. The results show that the SiO₂@TEuTTA/CS composite films not only have the smooth surface, high fluorescence property, good flexibility and transparency, but also can emit a bright red color under a 365 nm UV lamp. These provide an important basis for the application of the SiO₂@TEuTTA/CS composite films on the anti-counterfeiting packing labels. Addnl., the SiO₂@TEuTTA/CS solutions have been successfully used as anti-counterfeiting inks due to its transparency and pH sensitive properties. Compared with the traditional luminescent anti-counterfeiting inks, the pH sensitive SiO₂@TEuTTA/CS inks can improve the level of information security, which indicates that the SiO₂@TEuTTA/CS inks hold great promise for anti-counterfeiting fields. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application In Synthesis of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and bioactivities of phenazine-1-carboxylic piperazine derivatives was written by Han, Fei;Yan, Ru;Zhang, Min;Xiang, Zhu;Wu, Qinglai;Li, Junkai. And the article was included in Natural Product Research in 2020.Application of 620-19-9 This article mentions the following:

Phenazine-1-carboxylic acid (PCA) as a natural product which has significant inhibition effects against many soil-borne fungal phytopathogens in agricultural application and has been registered in China as the fungicide against rice sheath blight. In order to find new higher fungicidal activities lead compounds and develop new eco-friendly agrochems., we introduced substructure piperazines which also have high biol. activity into PCA, designed and synthesized a series of phenazine-1-carboxylic piperazine derivatives, and their structures were confirmed by ¹H NMR and HRMS. Most compounds exhibited certain in vitro fungicidal activities. In particular, Compounds exhibited the activity against all the tested pathogenic fungi, such as Rhizoctonia solani, Alternaria solani, Fusarium oxysporum, Fusarium graminearum, Pyricularia oryzae Cavgra, with the EC₅₀ value of 24.6渭M, 42.9渭M, 73.7渭M, 73.8渭M, 34.2渭M, resp., more potent activities than PCA (33.2渭M, 81.5渭M, 186.5渭M, 176.4渭M, 37.3渭M). This result provided a highly active lead compound for the further structure optimization design. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Application of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

N-doped carbon intercalated Fe-doped MoS₂ nanosheets with widened interlayer spacing: An efficient peroxymonosulfate activator for high-salinity organic wastewater treatment was written by Chen, Xi;Li, Songrong;Yang, Peizhen;Chen, Yunfeng;Xue, Cheng;Long, Yuhan;Han, Jiayan;Su, Jianming;Huang, Wenli;Liu, Dongfang. And the article was included in Journal of Colloid and Interface Science in 2022.Name: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

Peroxymonosulfate (PMS) heterogeneous catalysis dominated by nonradical pathway showed excellent adaptability for pollutant removal in complex water matrixes. Herein, ultra-small Fe-doped MoS₂ nanosheets with N-doped carbon intercalation (CF-MoS₂) were synthesized via a one-step hydrothermal method to treat high salinity organic wastewater. CF-MoS₂ exhibited an expanded interlayer spacing by 1.63 times and the sp. surface area by 9 times compared with Fe-doped MoS₂ (F-MoS₂), substantially increasing the active sites. Homogeneous Fe2+ catalytic experiments confirmed that the promotion of carbon intercalated MoS₂ (C-MoS₂) on Fe³⁺/Fe²⁺ redox cycle was much higher than pure MoS₂. Besides, the considerable removal of tetracycline (TC) under high salinity conditions (0-7.1%) was attributed to the dominant role of PMS nonradical oxidation pathways, including ¹O₂ and surface-bound radicals. The catalytic sites included Fe³⁺/Fe²⁺, Mo⁴⁺/Mo⁵⁺/Mo⁶⁺, C=O, pyridine N, pyrrolic N and hydroxyl groups. Finally, d. functional theory (DFT) was employed to get the radical electrophilic attack sites and nucleophile attack sites of TC, and the results were consistent with the TC degradation products determined by HPLC-MS. This work would broaden the application of MoS₂-based catalysts, especially for PMS catalytic removal of organic pollutants from high salinity wastewater. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Name: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An approach to 1-alkyl-3-phenylpiperidine derivatives containing 2,5-functionalized groups: 1-methyl-2-(4-chlorophenylthiomethyl)-3-(3-methoxyphenyl)-5-(methoxycarbonyl)piperidine was written by Kotzamani, Heleni K.;Gourdoupis, Christos G.;Stamos, Ioannis K.. And the article was included in Tetrahedron in 1994.Reference of 6834-42-0 This article mentions the following:

3-MeOC₆H₄CH₂COCH₂SC₆H₄Cl-4 (I) was synthesized by regiospecific addition of 4-chlorothiophenol to diazoketone 3-MeOC₆H₄CH₂COCHN₂ in the presence of a rhodium(II) acetate catalyst. Annulation of I with the enamine prepared from MeNH₂ and CH₂:C(CH₂Br)CO₂Me gave a tetrahydropyridine derivative Reduction of this compound with sodium cyanoborohydride in the presence of carboxylic acid produced the title compound In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper oxide nanoparticles using Mentha spicata leaves as antibacterial, antibiofilm, free radical scavenging agent and efficient photocatalyst to degrade methylene blue dyes was written by Malaikozhundan, Balasubramanian;Lakshmi, Venkatesan Namagiri;Krishnamoorthi, Raman. And the article was included in Materials Today Communications in 2022.Recommanded Product: 61-73-4 This article mentions the following:

In this findings, CuO NPs were made by an easy, eco-friendly, and economical approach using the leaf extract of M. spicata. The prepared Ms-CuO NPs exhibited characteristic absorbance peak at 320 nm with a band gap of 3.87 eV. XRD revealed the presence of crystalline particle with size of 11.28 nm as determined by the Scherrer equation. FTIR revealed the role of various functional mols. in the bio-reduction of copper salts to copper ions (Cu²⁺). The spherical shaped particles with the mean size of 36 nm were visualized through TEM microscopic image. EDX anal. also confirmed the elemental signals of Cu (91.58%) and O (8.42%) resp. The biosynthesized Ms-CuO NPs displayed a significant inhibition of Gram-pos. Streptococcus pyogenes and Staphylococcus aureus at all tested concentrations The inhibition size against S. pyogenes and S. aureus was 27.5 卤 0.5 mm and 26.2 卤 0.2 mm at 100渭g mL^-1 resp. On the other hand, the inhibition against K. pneumoniae and E. coli was 17.4 卤 0.6 mm and 18.2 卤 0.1 mm at 100渭g mL^-1 resp. Moreover, a significant inhibition of H₂O₂ (84%) at 100渭g mL^-1 demonstrates the free radical scavenging activity of Ms-CuO NPs. Furthermore, the Ms-CuO NPs have shown excellent degradation potential for industrial dyes i.e., Methylene blue (MB) and was noticed by the gradual decrease in the absorbance (at 460 nm) within 7 h of reaction. The percentage of MB dye degraded was 34% at 1 h which was substantially increased to 98% after 7 h. This study suggests that the Ms-CuO NPs may serve as a promising bactericidal, antibiofilm and antioxidant agent. Also, Ms-CuO NPs could be effectively used in the purification of water bodies contaminated with harmful industrial dyes to reduce toxicity. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Recommanded Product: 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antibacterial activity of novel icariin derivatives was written by Wang, A.;Zhang, Aili;Xu, Y.. And the article was included in Pharmazie in 2019.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

A series of aromatic sulfonyls substituted icariin derivatives I (R = 4-FC₆H₄, 4-F₃CC₆H₄, 2-thienyl, etc.) was synthesized and their antibacterial activities against S. aureus (including drug-sensitive bacteria and drug-resistant bacteria) were evaluated. Among them, compound I (R = 4-F₃CC₆H₄) exhibited high potency against methicillin-sensitive (MSSA) and resistant strains of S. aureus (MRSA) with MIC values of 1-2 mmol/L. Reverse virtual screening and mol. docking anal. indicated that compound I (R = 4-F₃CC₆H₄) might bind the allosteric site of PBP2a that may inhibit cell wall synthesis, with the advantage of activity against multidrug resistant S. aureus. Surface plasmon resonance (SPR) experiment further confirmed the binding affinity. Therefore, aromatic sulfonyls at C-3 position substituted icariin derivatives have been considered to be a novel class of anti-MRSA agents worth of further investigation. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics