Andronati, Serhiy A.; Pavlovsky, Viktor I.; Golovenko, Mykola Ya.; Reder, Anatoliy S.; Larionov, Vitalii B.; Valivodz’., Irina P. published the artcile< Synthesis and extraction efficiency from biological fluids of [214C]Propoxazepam: a potent analgesic with multifunctional mechanism of action>, HPLC of Formula: 128-09-6, the main research area is synthesis extraction biol fluid propoxazepam analgesic pharmacokinetic study.
A method has been developed for the synthesis of isotopically labeled 7-bromo-5-(2-chlorophenyl)-3-propoxy-1H-benzo[e][1,4]diazepin- 2(3H)-one (Propoxazepam) in a six-step synthesis starting from [1 14C]Glycine with the 30% yield. [214C]Propoxazepam was isolated with a specific activity of 2,68 μ Ci/mol, a chem. purity of 99.0%, and a radiochem. purity of 89.8%. In the model experiments there were rationed the quantity of sequential extractions and extragents volumes ratio to provide 90%, 95% or 99% of significance level extraction The estimated anal. characteristics of the method (coefficient of variation ωs = 3,33%, relative error ε = 9,53%) make it possible for use in pharmacokinetic studies in animals.
Journal of Chemical, Biological and Physical Sciences published new progress about Analgesics. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, HPLC of Formula: 128-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics