Fritzson, Ingela; Bedingfield, Paul T. P.; Sundin, Anders P.; McConkey, Glenn; Nilsson, Ulf J. published the artcile< N-Substituted salicylamides as selective malaria parasite dihydroorotate dehydrogenase inhibitors>, Name: Methyl 4-chloro-2-hydroxybenzoate, the main research area is substituted salicylamide recombinant human Plasmodium dihydroorotate dehydrogenase inhibitor.
In our continuing program to develop Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors, a series of N-substituted salicylamides were synthesized and their ability to selectively inhibit PfDHODH was examined The synthetic program was based on 2-hydroxy-N-(2-phenylethyl)benzamide (1) that weakly inhibits both PfDHODH and human DHODH (hDHODH). Structure activity relationships were examined for developing derivatives Selective PfDHODH inhibitors with improved potency were obtained by introducing a 2,2-diphenylethyl substitution on the salicylamidic nitrogen. Biol. activity of the most potent compounds was confirmed on parasite infected cells in vitro.
MedChemComm published new progress about Erythrocyte. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Name: Methyl 4-chloro-2-hydroxybenzoate.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics