Roggen, Heidi; Gundersen, Lise-Lotte published the artcile< Synthetic studies directed towards agelasine analogs - synthesis, tautomerism, and alkylation of 2-substituted N-methoxy-9-methyl-9H-purin-6-amines>, Application of C6H4Cl2N4, the main research area is agelasine analog synthetic study; methoxypurinamine preparation regioselective alkylation; benzylmethoxyamino purine preparation; regioselectivity alkylation methoxypurinamine; tautomer ratio methoxypurinamine.
Methoxypurinamines I [R = H, Me, F3C, Cl, O2N; R1 = (MeO)NH], potential intermediates in the preparation of agelasine analogs, are prepared by substitution of I (R1 = Cl) with O-methylhydroxylamine hydrochloride, while I [R = MeO, EtO, Me2N, MeNH; R1 = (MeO)NH] are prepared by substitution reactions of I [R = Cl; R1 = (MeO)NH]. I [R = H, Me, MeO, EtO, MeNH; R1 = (MeO)NH] exist as mixtures of their methoxyamino and methoxyimino tautomers in solution, with the relative concentrations of the tautomers differing substantially between species. Alkylation of I [R = H, Me, MeO, EtO, Me2N, MeNH; R1 = (MeO)NH] with benzyl bromide gives mixtures of purinium bromides II (R = H, Me, EtO, Me2N, MeNH) and (benzylmethoxyamino)purines I [R = H, Me, MeO, EtO, Me2N, MeNH; R1 = (PhCH2)(MeO)N], while methoxypurinamines with strongly electron-withdrawing substituents are not reactive under similar conditions.
European Journal of Organic Chemistry published new progress about Alkylation. 2382-10-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H4Cl2N4, Application of C6H4Cl2N4.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics