Chlorinated organic compounds are found in nearly every class of biomolecules. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Related Products of 104-86-9.
Escudero, Julien;Mampuys, Pieter;Mensch, Carl;Bheeter, Charles B.;Vroemans, Robby;Orru, Romano V. A.;Harvey, Jeremy;Maes, Bert U. W. research published 《 Synthesis of Heterocycles via Aerobic Ni-Catalyzed Imidoylation of Aromatic 1,2-Bis-nucleophiles with Isocyanides》, the research content is summarized as follows. O-Phenylene N-substituted iminocarbonates I (R = cyclohexyl, i-Pr, t-Bu, etc.; R1 = OMe, H; R2 = H, OMe, NO2, CH2CH2C=O(OMe), etc.) have been obtained by aerobic Ni-catalyzed reaction of readily available catechols 2-(OH)-3-R1-5-R2C6H2OH and isocyanides RNC. The choice of oxidant and absence of base proved crucial to avoid competitive catechol oxidation into (semi)quinone, leading to degradation The developed protocol is generally applicable on other oxidation-sensitive aromatic 1,2-bis-nucleophiles, generating a variety of important bicyclic heterocycles from readily available building blocks, hitherto only accessible via aerobic noble metal catalysis. Exptl. studies suggest involvement of a NiII-catecholate complex, which has been supported by d. functional theory of the catalytic cycle. O-Phenylene N-substituted iminocarbonates demonstrated to be interesting platform mols. providing access to dialkyl N-substituted iminocarbonates RN=C(OR3)2 (R = cyclohexyl, t-Bu, 4-MeOC6H4CH2CH2; R3 = n-Bu, Me, Bn, etc.), Di-Bu [2-(4-methoxyphenyl)ethyl]carbonodithioimidate, and N,N’-Dibutyl N”-[2-(4-methoxyphenyl)ethyl]guanidine via reaction with resp. alcs. R3OH, 1-butanethiol, and 1-butanamine. The catechol, which is concomitantly produced as a byproduct in these substitution reactions, can be recycled. When 4-propylcatechol, accessible from pine and clove tree feedstock, is applied, the leaving group is also biorenewable.
Related Products of 104-86-9, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., 104-86-9.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics