Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4144-22-3, is researched, SMILESS is O=C(C=C1)N(C(C)(C)C)C1=O, Molecular C8H11NO2Journal, Advanced Synthesis & Catalysis called 1,2-Diamine-Derived (thio)Phosphoramide Organocatalysts in Asymmetric Michael Additions, Author is Kozma, Viktoria; Fueloep, Ferenc; Szollosi, Gyoergy, the main research direction is aldehyde ketone maleimide asym Michael addition phosphoramide thiophosphoramide catalyst; phosphoramide thiophosphoramide diamine catalyst preparation.Name: 1-(tert-Butyl)-1H-pyrrole-2,5-dione.
Phosphoramides and thiophosphoramides were prepared from optically pure C2-sym. 1,2-diamines and were used as chiral organocatalysts in the asym. Michael additions of aldehydes and ketones to N-substituted maleimides. The 1,2-diphenylethane-1,2-diamine derived thiophosphoramide, which could be prepared in good yield in a one-step procedure, was found to be more active and selective catalyst in the addition of aldehydes to various maleimide derivatives, when compared to sulfonamides having the same backbone. Products resulted in reactions of ketones with maleimides were also obtained in high yields and enantioselectivities. The thiophosphoramide derivative was also efficient in the asym. conjugate addition of carbonyl compounds to β-nitrostyrene and in the reaction of nitromethane with α,β-unsaturated ketones. Based on results obtained with (thio)phosphoramides in asym. additions to maleimides it was suggested that a weaker, more flexible hydrogen-bonding of the rigid electrophile to the catalyst is responsible for the improved performance of these bifunctional organocatalysts, as compared with sulfonamides.
Although many compounds look similar to this compound(4144-22-3)Name: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, numerous studies have shown that this compound(SMILES:O=C(C=C1)N(C(C)(C)C)C1=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics