Li, Feng; Zhou, Yirong; Yang, Heng; Liu, Dandan; Sun, Bing; Zhang, Fang-Lin published the article 《Assembly of Diverse Spirocyclic Pyrrolidines via Transient Directing Group Enabled Ortho-C(sp2)-H Alkylation of Benzaldehydes》. Keywords: formylaryl succinimide regioselective diversity oriented preparation; spirocyclic imide preparation; ruthenium catalyst transiently directed regioselective alkylation aryl aldehyde maleimide; spirocyclization formylaryl succinimide.They researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).Recommanded Product: 4144-22-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4144-22-3) here.
In the presence of [RuCl2(p-cymene)]2, AgSbF6, and 4-chlorobenzoic acid, aryl aldehydes such as 2,4-dimethylbenzaldehyde underwent directed regioselective alkylation reactions with maleimides such as N-ethylmaleimide via formation of transient imine directing groups with 2-methyl-3-trifluoromethylaniline to yield formylarylsuccinimides such as I chemo- and regioselectively. Alkylation by maleimides proximal to the aldehyde is preferred over alkylation near other directing groups such as carbamates and pyrazoles, allowing for the synthesis of formylaryl-substituted imides. Spirocyclization of I with a variety of reactants such as 1,2,3,4-tetrahydroisoquinoline yielded nine pyrrolidine-containing spirocycles such as II. Only 0.5 mol % of ruthenium catalyst was sufficient to prepare I on 100 mmol scale (22 g scale, 86% yield) without column chromatog. purification
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics