The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Next generation risk assessment of human exposure to anti-androgens using newly defined comparator compound values, the main research direction is human risk assessment DIM bicalutamide antiandrogens; 3R compliant method; Androgen receptor; Dietary comparator; In vitro/in silico approaches; Risk assessment.Computed Properties of C17H14N2.
Next Generation Risk Assessment (NGRA) can use the so-called Dietary Comparator Ratio (DCR) to evaluate the safety of a defined exposure to a compound of interest. The DCR compares the Exposure Activity Ratio (EAR) for the compound of interest, to the EAR of an established safe level of human exposure to a comparator compound with the same putative mode of action. A DCR ≤ 1 indicates the exposure evaluated is safe. The present study aimed at defining adequate and safe comparator compound exposures for evaluation of anti-androgenic effects, using 3,3-diindolylmethane (DIM), from cruciferous vegetables, and the anti-androgenic drug bicalutamide (BIC). EAR values for these comparator compounds were defined using the AR-CALUX assay. The adequacy of the new comparator EAR values was evaluated using PBK modeling and by comparing the generated DCRs of a series of test compound exposures to actual knowledge on their safety regarding in vivo anti-androgenicity. The use of AR-CALUX-based comparator EARs for DCR-based NGRA for putative anti-androgenic compounds This further validates the DCR approach as an animal free in silico/in vitro 3R compliant method in NGRA.
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics