Butler, Richard N.; Coyne, Anthony G.; McArdle, Patrick; Sibley, Lisa M.; Burke, Luke A. published the article 《Uncharacteristic thione behavior in a Huisgen cycloaddition reaction: A kinetic and theoretical study》. Keywords: dipolar Huisgen cycloaddition adamantanethione phthalazinium cyanomethanide thiazolophthalazine.They researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).HPLC of Formula: 4144-22-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4144-22-3) here.
In the reaction of phthalazinium-2-dicyanomethanide with adamantanethione the rare ring system [1,3]thiazolo[2,3-a]phthalazine was obtained. An x-ray crystal structure of the product shows regioselectivity with the thione carbon bonded to the dicyanomethanide terminus of the 1,3-dipole. UV kinetic measurements and DFT calculations showed that the rate of cycloaddition of adamantanethione was significantly slower than that of DMAD and no super-dipolarophile character was exhibited. This arose from exceptional lowering of the HOMO energy of the 1,3-dipole by the cyano substituents.
This literature about this compound(4144-22-3)HPLC of Formula: 4144-22-3has given us a lot of inspiration, and I hope that the research on this compound(1-(tert-Butyl)-1H-pyrrole-2,5-dione) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics