Application In Synthesis of 1-Chloro-2-methylbenzene. Recently I am researching about N-HETEROCYCLIC CARBENE; DIRECT C-5 ARYLATION; HIGHLY EFFICIENT; DIRECT (HETERO)ARYLATION; DIRECT C5-ARYLATION; METAL-COMPLEXES; HECK REACTION; IMIDAZOLES; BOND; FUNCTIONALIZATION, Saw an article supported by the Ministry of Science and Technology of TaiwanMinistry of Science and Technology, Taiwan [MOST 107-2113-M-018-002]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Lee, JY; Ghosh, D; Kuo, YT; Lee, HM. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene
A series of dimetallic palladium(II)-NHC complexes comprised of 1,4-naphthalenyl or 9,10-anthracenyl spacer sandwiched between two imidazole rings was successfully synthesized. These complexes were characterized by H-1 and C-13{H-1} NMR spectroscopy and elemental analysis. The structures of two dimetallic palladium complexes and a related mononuclear palladium complex to be used for comparative studies were further characterized by X-ray diffraction. The dimetallic palladium complex with the 9,10-anthracenyl linker was very efficient in catalyzing direct C-H arylation reactions of heteroaromatic compounds (imidazoles, imidazo[1,2-a]pyridine, and thioazole) with a broad range of aryl chlorides, employing a mild monopalladium loading of 1.5 mol%. It allows for the effective use of aryl chlorides to prepare arylated heterocycles, previously only accessible with the more reactive bromide counterparts. Importantly, the catalytic activity of the dimetallic precatalyst was found to be higher than that of an analogous mononuclear complex.
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Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
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