In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 918538-05-3, name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
Example 103 A: To a stirring solution of 2,4-dichloropyrrolo[l ,2- f][ l ,2,4]triazine (Mastalerz, et al. US20070004731 Al) (1.0 g, 5.3 mmol) in CH3CN at rt was added SelectFluor (N-chloromethyl-N-fluorotriethylenediammoniumbis(tetrafluoroborate) ( 1.89 g, 5.3 mmol). The mixture was stirred at rt for 2 h, and then heated at 80 C for 2 h. The mixture was concentrated and the residue waspurified by silica gel chromatography eluting with 0-5% EtOAc in hexanes to give an impure sample of 2,4-dichloro-7-fluoropyrrolo[l,2-f][l,2,4]tria2ine (750 mg).
The synthetic route of 918538-05-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMBIT BIOSCIENCES CORPORATION; ABRAHAM, Sunny; BHAGWAT, Shripad, S.; HADD, Michael, J.; HOLLADAY, Mark, W.; LIU, Gang; MILANOV, Zdravko, V.; PATEL, Hitesh, K.; SETTI, Eduardo; SINDAC, Janice, A.; WO2011/88045; (2011); A1;,
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