I found the field of Chemistry very interesting. Saw the article Nickel-Catalyzed Mono-Selective alpha-Arylation of Acetone with Aryl Chlorides and Phenol Derivatives published in 2020.0. COA of Formula: C7H7Cl, Reprint Addresses Tlili, A; Amgoune, A (corresponding author), Univ Lyon 1, Univ Lyon, Inst Chem & Biochem ICBMS UMR CNRS 5246, CNRS,INSA,CPE Lyon, 1 Rue Victor Grignard, F-69622 Villeurbanne, France.; Amgoune, A (corresponding author), Inst Univ France IUF, 1 Rue Descartes, F-75231 Paris 05, France.. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene
The challenging nickel-catalyzed mono-alpha-arylation of acetone with aryl chlorides, pivalates, and carbamates has been achieved for the first time. A nickel/Josiphos-based catalytic system is shown to feature unique catalytic behavior, allowing the highly selective formation of the desired mono-alpha-arylated acetone. The developed methodology was applied to a variety of (hetero)aryl chlorides including biologically relevant derivatives. The methodology has been extended to the unprecedented coupling of acetone with phenol derivatives. Mechanistic studies allowed the isolation and characterization of key Ni(0)and Ni(II)catalytic intermediates. The Josiphos ligand is shown to play a key role in the stabilization of Ni(II)intermediates to allow a Ni-0/Ni(II)catalytic pathway. Mechanistic understanding was then leveraged to improve the protocol using an air-stable Ni(II)pre-catalyst.
Welcome to talk about 95-49-8, If you have any questions, you can contact Abou Derhamine, S; Krachko, T; Monteiro, N; Pilet, G; Schranck, J; Tlili, A; Amgoune, A or send Email.. COA of Formula: C7H7Cl
Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
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