Adding a certain compound to certain chemical reactions, such as: 4584-46-7, name is 2-Chloro-N,N-dimethylethanamine hydrochloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4584-46-7, category: chlorides-buliding-blocks
General procedure: In a dried single-neck round bottom flask, 4-hydroxylbenzaldehyde (40 mmol), potassium carbonate (122 mmol) and dry acetone (160 ml) were taken and the contents refluxed for 2 h. The reaction mixture was brought to room temperature and catalytic amount of potassium iodide was added, followed by the gradual addition of appropriate dialkylaminoethyl chloride hydrochloride (45 mmol) dissolved in dry acetone (50 ml) through a pressure-equalizing addition funnel and the reaction mixture was allowed to reflux again. The contents were regularly monitored for reaction progress by TLC using 10% methanol/dichloromethane as the solvent system. The reaction was generally complete in 10-13 h. At this point, reaction mixture was filtered under suction and the solid inorganic salts were washed with acetone (3 ¡Á 60 ml). The solvent was evaporated under reduced pressure and the residue was purified by column chromatography over silica gel (6-8% methanol in dichloromethane, v/v as eluent) to afford the pure aldehydes 4a-f as colorless oils in 49-92% yields. The structures of 4a-f were unambiguously established from the comparison of their spectral data with reported values [13,24,25]. The spectroscopic data of compound 4b which is not reported in literature is being included here.
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Reference:
Article; Yadav, Yogesh; MacLean, Erin D.; Bhattacharyya, Annyt; Parmar, Virinder S.; Balzarini, Jan; Barden, Christopher J.; Too, Catherine K.L.; Jha, Amitabh; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 3858 – 3866;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics