Recently I am researching about MULTIPLE-SCLEROSIS; HEPATITIS; DISEASES; GAMMA; BETA, Saw an article supported by the Korea Institute of Science and Technology (KIST) Institutional ProgramKorea Institute of Science & Technology (KIST) [2E30180]; Bio & Medical Technology Development Program of the National Research Foundation – Korean government (MSIT) [NRF-2019M3E5D4066905]; Priority Research Centers Program – National Research Foundation of Korea (NRF) [2019R1A6A1A11051471, 2020R1C1C1010044]; Convergence brain research through cross-institute collaboration [KBRI 20-BR-0301/IBS-R001-D1-2020-b02]. Quality Control of 2,4-Dichlorobenzoic acid. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Chu, Y; Reddy, BRS; Gajulapalli, VPR; Babu, KS; Kim, E; Lee, S. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid
Type I Interferon (IFN) signaling plays an important role in the immune defense system against virus infection and in the innate immune response, thus IFNs are widely used as anti-viral agents and treatment for immune disorder or cancer. However, there is a growing demand for novel small-molecule IFN inducer due to tolerance, toxicity, or short duration of action following direct administration of IFNs. In this study, we assessed arylpiperazine (ARP) as a new core skeleton of IFN inducer. To investigate structure-activity relationship, we designed and synthesized a series of ARP analogues and evaluated the ability to stimulate IFN response in THP-1 human monocyte cells. Compound 5i was identified as a potent type I IFN inducer as it significantly increased cytokine secretion and increased expression of various IFN-stimulating genes which are representative biomarkers of type I IFN pathway. Our results suggested a beneficial therapeutic potential of 5i as an anti-viral agent.
Quality Control of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Chu, Y; Reddy, BRS; Gajulapalli, VPR; Babu, KS; Kim, E; Lee, S or concate me.
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics