13078-79-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13078-79-0, name is 2-(3-Chlorophenyl)ethanamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
3-Hydroxy-4-(4-methyl-1/-/-imidazol-1-yl)benzoic acid, hydrobromide salt from the previous experiment (300 mg, 1.00 mmol) was combined with 2-(3-chlorophenyl)ethanamine (321 mg, 2.06 mmol), 1/-/-benzotriazol-1-ol (HOBT, 279 mg, 2.06 mmol), diisopropylethylamine (0.94 ml_, 5.50 mmol) in dimethylformamide (6.9 ml_)and the mixture was stirred until dissolved. Lambda/-[3- (dimethylamino)propyl]-Lambda/’-ethylcarbodiimide hydrochloride (EDCI, 320 mg, 2.06 mmol) was added, and the reaction was stirred for 18 hours. The reaction mixture was poured into water (100 ml_) and extracted with ethyl acetate (3 x 100 ml_). The combined organic layers were dried over magnesium sulfate, filtered and concentrated under reduced pressure. Chromatography on silica (Mobile phase A: ethyl acetate; Mobile phase B: 9:1 ethyl acetate: [2M ammonia in methanol]; Gradient: 50%B to 100%B) afforded the title compound. Yield: 280 mg, 0.787 mmol, 77%. LCMS m/z 356.1 , 358.1 (M+1 ). 1H NMR (400 MHz, CD3OD) delta 2.24 (br s, 3H), 2.91 (t, J=7.3 Hz, 2H), 3.58 (t, J=7.3 Hz, 2H), 7.16-7.22 (m, 3H), 7.25-7.30 (m, 3H), 7.37 (d, J=8.3 Hz, 1 H), 7.44 (d, J=1.9 Hz, 1 H), 7.94 (d, J=1.2 Hz, 1 H).
The synthetic route of 13078-79-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; ALLEN, Martin, Patrick; AM ENDE, Christopher, William; BRODNEY, Michael, Aaron; DOUNAY, Amy, Beth; JOHNSON, Douglas, Scott; PETTERSSON, Martin, Youngjin; SCHWARZ, Jacob, Bradley; TRAN, Tuan, Phong; WO2010/100606; (2010); A1;,
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