I found the field of Biochemistry & Molecular Biology; Cell Biology very interesting. Saw the article Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity published in 2021.0. SDS of cas: 95-49-8, Reprint Addresses Lee, BJ (corresponding author), Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 08826, South Korea.; Lee, SJ (corresponding author), POSTECH, Pal XFEL, Pohang Accelerator Lab, Pohang 37673, Gyeongbuk, South Korea.. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene
NAD(P)-dependent steroid dehydrogenase-like (NSDHL), an essential enzyme in human cholesterol synthesis and a regulator of epidermal growth factor receptor (EGFR) trafficking pathways, has attracted interest as a therapeutic target due to its crucial relevance to cholesterol-related diseases and carcinomas. However, the development of pharmacological agents for targeting NSDHL has been hindered by the absence of the atomic details of NSDHL. In this study, we reported two X-ray crystal structures of human NSDHL, which revealed a detailed description of the coenzyme-binding site and the unique conformational change upon the binding of a coenzyme. A structure-based virtual screening and biochemical evaluation were performed and identified a novel inhibitor for NSDHL harboring suppressive activity towards EGFR. In EGFR-driven human cancer cells, treatment with the potent NSDHL inhibitor enhanced the antitumor effect of an EGFR kinase inhibitor. Overall, these findings could serve as good platforms for the development of therapeutic agents against NSDHL-related diseases.
SDS of cas: 95-49-8. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Kim, DG; Cho, S; Lee, KY; Cheon, SH; Yoon, HJ; Lee, JY; Kim, D; Shin, KS; Koh, CH; Koo, JS; Choi, Y; Lee, HH; Oh, YK; Jeong, YS; Chung, SJ; Baek, M; Jung, KY; Lim, HJ; Kim, HS; Park, SJ; Lee, JY; Lee, SJ; Lee, BJ or concate me.
Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
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