I found the field of Pharmacology & Pharmacy very interesting. Saw the article Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor gamma t (ROR gamma t) Inverse Agonists published in 2020.0. Computed Properties of C7H4Cl2O2, Reprint Addresses Brunsveld, L (corresponding author), Tech Univ Eindhoven, Lab Chem Biol, Dept Biomed Engn, Dolech 2, NL-5612 AZ Eindhoven, Netherlands.; Brunsveld, L (corresponding author), Tech Univ Eindhoven, Inst Complex Mol Syst, Dolech 2, NL-5612 AZ Eindhoven, Netherlands.. The CAS is 50-30-6. Through research, I have a further understanding and discovery of 2,6-Dichlorobenzoic acid
Retinoic acid receptor-related orphan receptor gamma t (ROR gamma t) is a nuclear receptor associated with the pathogenesis of autoimmune diseases. Allosteric inhibition of ROR gamma t is conceptually new, unique for this specific nuclear receptor, and offers advantages over traditional orthosteric inhibition. Here, we report a highly efficient in silico-guided approach that led to the discovery of novel allosteric ROR gamma t inverse agonists with a distinct isoxazole chemotype. The the most potent compound, 25 (FM26), displayed submicromolar inhibition in a coactivator recruitment assay and effectively reduced IL-17a mRNA production in EM cells, a marker of ROR gamma t activity. The projected allosteric mode of action of 25 was confirmed by biochemical experiments and cocrystallization with the ROR gamma t ligand binding domain. The isoxazole compounds have promising pharmacokinetic properties comparable to other allosteric ligands but with a more diverse chemotype. The efficient ligand-based design approach adopted demonstrates its versatility in generating chemical diversity for allosteric targeting of ROR gamma t.
Computed Properties of C7H4Cl2O2. About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Meijer, FA; Doveston, RG; de Vries, RMJM; Vos, GM; Vos, AAA; Leysen, S; Scheepstra, M; Ottmann, C; Milroy, LG; Brunsveld, L or concate me.
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Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics