Related Products of 210532-25-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 210532-25-5 name is 3,5-Difluorobenzene-1-sulfonyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A mixture of (4-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d] pyrimidin-7-yl) methyl pivalate 6 (1.00 g, 0.0037 mol) andtriethylaminein (1.12 g, 0.011 mol) were dissolved in N,N-dimethylacetamide(10 ml), followed by addition of various sulfonyl chloride(0.0044 mol) and was stirred at 60 C for 4 h. The reaction mixture waspoured into ice water (50 ml). The residue was filtered and washed withwater, and dried to give compounds 7a-7p.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Difluorobenzene-1-sulfonyl chloride, and friends who are interested can also refer to it.
Reference:
Article; Jiang, Feng; Zang, Linghe; Miao, Xiuqi; Jia, Fang; Wang, Jie; Zhu, Minglin; Gong, Ping; Jiang, Nan; Zhai, Xin; Bioorganic and Medicinal Chemistry; vol. 27; 18; (2019); p. 4089 – 4100;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics